AutismKB 2.0

Annotation Details for TNFRSF11A


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Basic Information Top
Gene Symbol:TNFRSF11A ( CD265,FEO,LOH18CR1,ODFR,OFE,OPTB7,OSTS,PDB2,RANK,TRANCER )
Gene Full Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Band: 18q21.33
Quick LinksEntrez ID:8792; OMIM: 603499; Uniprot ID:TNR11_HUMAN; ENSEMBL ID: ENSG00000141655; HGNC ID: 11908
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005829IDA-cytosol-
GO:0005886IDA-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005887IBA-integral component of plasma membrane-
GO:0009897IDA-external side of plasma membrane9367155
GO ID Evidence Qualifier GO_term References
GO:0004872TAS-receptor activity9367155
GO:0004888IDA-transmembrane signaling receptor activity9367155
GO:0005031IBA-tumor necrosis factor-activated receptor activity-
GO:0005031ISS-tumor necrosis factor-activated receptor activity19940926
GO:0005515IPI-protein binding15750601
GO:0019955IPI-cytokine binding9367155
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0001503IEA-ossification-
GO:0002250IMP-adaptive immune response18606301
GO:0002548NAS-monocyte chemotaxis15248232
GO:0006954IBA-inflammatory response-
GO:0007165TAS-signal transduction9367155
GO:0007267TAS-cell-cell signaling9367155
GO:0008284TAS-positive regulation of cell proliferation9367155
GO:0009314IEA-response to radiation-
GO:0030316IMP-osteoclast differentiation18606301
GO:0032496IBA-response to lipopolysaccharide-
GO:0032496ISS-response to lipopolysaccharide19940926
GO:0033209ISS-tumor necrosis factor-mediated signaling pathway19940926
GO:0033209TAS-tumor necrosis factor-mediated signaling pathway-
GO:0034097IMP-response to cytokine18606301
GO:0034612ISS-response to tumor necrosis factor19940926
GO:0042981IBA-regulation of apoptotic process-
GO:0043507IMP-positive regulation of JUN kinase activity12296995
GO:0048535IEA-lymph node development-
GO:0051091IDA-positive regulation of sequence-specific DNA binding transcription factor activity12296995
GO:0051091ISS-positive regulation of sequence-specific DNA binding transcription factor activity19940926
GO:0051092IDA-positive regulation of NF-kappaB transcription factor activity9367155
GO:0051092IMP-positive regulation of NF-kappaB transcription factor activity12296995
GO:0060086ISS-circadian temperature homeostasis19940926
GO:0060749IEA-mammary gland alveolus development-
GO:0070555ISS-response to interleukin-119940926
GO:0071812ISS-positive regulation of fever generation by positive regulation of prostaglandin secretion19940926
GO:0071847IMP-TNFSF11-mediated signaling pathway18606301
GO:0071848IMP-positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling18606301
GO:0097190IBA-apoptotic signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TNFRSF11AMAP3K711274811809792 Affinity Capture-Western
TNFRSF11AMAP3K711432011809792 Affinity Capture-Western
TNFRSF11ATRAF11143209852070 10025951 Affinity Capture-Western; Reconstituted Complex
TNFRSF11ATRAF11130379852070 10025951 Affinity Capture-Western; Reconstituted Complex
TNFRSF11ATRAF21143209685412 9852070 10025951 10075662 Affinity Capture-Western; Reconstituted Complex
TNFRSF11ATRAF21130389685412 9852070 10025951 10075662 Affinity Capture-Western; Reconstituted Complex
TNFRSF11ATRAF31143209852070 10025951 Affinity Capture-Western; Reconstituted Complex
TNFRSF11ATRAF31130399852070 10025951 Affinity Capture-Western; Reconstituted Complex
TNFRSF11ATRAF51130409685412 9852070 10075662 Reconstituted Complex
TNFRSF11ATRAF51143209685412 9852070 10075662 Reconstituted Complex
TNFRSF11ATRAF61130419685412 9852070 10025951 10075662 11809792 Affinity Capture-Western; Reconstituted Complex
TNFRSF11ATRAF61143209685412 9852070 10025951 10075662 11809792 Affinity Capture-Western; Reconstituted Complex
TAB2TNFRSF11A11674011809792 Affinity Capture-Western
TAB2TNFRSF11A11432011809792 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1314891
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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