Gene Symbol:	TNFRSF10B ( CD262,DR5,KILLER,KILLER/DR5,TRAIL-R2,TRAILR2,TRICK2,TRICK2A,TRICK2B,TRICKB,ZTNFR9 )
Gene Full Name:	tumor necrosis factor receptor superfamily, member 10b
Band:	8p21.3
Quick Links	Entrez ID:8795; OMIM: 603612; Uniprot ID:TR10B_HUMAN; ENSEMBL ID: ENSG00000120889; HGNC ID: 11905
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005622	IEA	-	intracellular	-
GO:0005886	TAS	-	plasma membrane	-
GO:0005887	IBA	-	integral component of plasma membrane	-
GO:0009986	IDA	-	cell surface	22952982
GO:0016021	IC	-	integral component of membrane	9311998

GO ID	Evidence	Qualifier	GO_term	References
GO:0004872	NAS	-	receptor activity	9311998
GO:0005031	IBA	-	tumor necrosis factor-activated receptor activity	-
GO:0005515	IPI	-	protein binding	10549288
GO:0045569	NAS	-	TRAIL binding	9373179

GO ID	Evidence	Qualifier	GO_term	References
GO:0006915	NAS	-	apoptotic process	9430227
GO:0006919	TAS	-	activation of cysteine-type endopeptidase activity involved in apoptotic process	-
GO:0006954	IBA	-	inflammatory response	-
GO:0006955	IBA	-	immune response	-
GO:0007166	TAS	-	cell surface receptor signaling pathway	-
GO:0007250	NAS	-	activation of NF-kappaB-inducing kinase activity	9430227
GO:0007275	IBA	-	multicellular organism development	-
GO:0008625	NAS	-	extrinsic apoptotic signaling pathway via death domain receptors	9311998
GO:0032496	IBA	-	response to lipopolysaccharide	-
GO:0033209	IEA	-	tumor necrosis factor-mediated signaling pathway	-
GO:0034976	IDA	-	response to endoplasmic reticulum stress	15322075
GO:0042127	IBA	-	regulation of cell proliferation	-
GO:0042981	IBA	-	regulation of apoptotic process	-
GO:0042981	NAS	-	regulation of apoptotic process	10549288
GO:0042981	TAS	-	regulation of apoptotic process	-
GO:0043123	IEP	-	positive regulation of I-kappaB kinase/NF-kappaB signaling	12761501
GO:0050900	TAS	-	leukocyte migration	-
GO:0070059	IMP	-	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	15322075
GO:0070059	TAS	-	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	22934019
GO:0071260	IEP	-	cellular response to mechanical stimulus	19593445
GO:0097296	TAS	-	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	-
GO:1902041	TAS	-	regulation of extrinsic apoptotic signaling pathway via death domain receptors	-
GO:1902042	TAS	-	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	-

Gene Symbol	Interactant	Interaction ID	References	Description
TNFRSF10B	FAS	106851	15659383	Co-purification
TNFRSF10B	FAS	114323	15659383	Co-purification
TNFRSF10B	FASLG	114323	15659383	Co-purification
TNFRSF10B	FASLG	106852	15659383	Co-purification
TNFRSF10B	RHOA	114323	15659383	Co-purification
TNFRSF10B	RHOA	106880	15659383	Co-purification
TNFRSF10B	ARHGDIA	106889	15659383	Co-purification
TNFRSF10B	ARHGDIA	114323	15659383	Co-purification
TNFRSF10B	BID	114323	15659383	Co-purification
TNFRSF10B	BID	107106	15659383	Co-purification
TNFRSF10B	CASP8	114323	9325248 11940602 15659383	Affinity Capture-Western; Co-purification
TNFRSF10B	CASP8	107291	9325248 11940602 15659383	Affinity Capture-Western; Co-purification
TNFRSF10B	CASP10	114323	9325248 15659383	Affinity Capture-Western; Co-purification
TNFRSF10B	CASP10	107293	9325248 15659383	Affinity Capture-Western; Co-purification
TNFRSF10B	MSN	114323	15659383	Co-purification
TNFRSF10B	MSN	110584	15659383	Co-purification
TNFRSF10B	MAPK8	111585	15659383	Co-purification
TNFRSF10B	MAPK8	114323	15659383	Co-purification
TNFRSF10B	TNFRSF1A	112986	15659383	Co-purification
TNFRSF10B	TNFRSF1A	114323	15659383	Co-purification
TNFRSF10B	EZR	114323	15659383	Co-purification
TNFRSF10B	EZR	113271	15659383	Co-purification
TNFRSF10B	TRADD	114257	9430227	Affinity Capture-Western
TNFRSF10B	TRADD	114323	9430227	Affinity Capture-Western
TNFRSF10B	RIPK1	114274	9430227	Affinity Capture-Western
TNFRSF10B	RIPK1	114323	9430227	Affinity Capture-Western
TNFRSF10B	TNFSF10	114280	9311998 10549288 11094155	Affinity Capture-MS; Co-crystal Structure; Reconstituted Complex
TNFRSF10B	TNFSF10	114323	9311998 10549288 11094155	Affinity Capture-MS; Co-crystal Structure; Reconstituted Complex
TNFRSF10B	FADD	114302	9430227 11940602 15659383	Affinity Capture-Western; Co-purification
TNFRSF10B	FADD	114323	9430227 11940602 15659383	Affinity Capture-Western; Co-purification
CFLAR	TNFRSF10B	114364	9325248 11940602	Affinity Capture-Western
CFLAR	TNFRSF10B	114323	9325248 11940602	Affinity Capture-Western
TIMM50	TNFRSF10B	124961	15044455	Two-hybrid
TIMM50	TNFRSF10B	114323	15044455	Two-hybrid

AutismKB 2.0

Annotation Details for TNFRSF10B

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