Gene Symbol:	TNFRSF10A ( APO2,CD261,DR4,MGC9365,TRAILR-1,TRAILR1 )
Gene Full Name:	tumor necrosis factor receptor superfamily, member 10a
Band:	8p21.3
Quick Links	Entrez ID:8797; OMIM: 603611; Uniprot ID:TR10A_HUMAN; ENSEMBL ID: ENSG00000104689; HGNC ID: 11904
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005622	IEA	-	intracellular	-
GO:0005886	TAS	-	plasma membrane	-
GO:0005887	IBA	-	integral component of plasma membrane	-
GO:0009986	IDA	-	cell surface	22952982
GO:0016021	IC	-	integral component of membrane	9311998

GO ID	Evidence	Qualifier	GO_term	References
GO:0002020	IPI	-	protease binding	21785459
GO:0004872	NAS	-	receptor activity	9311998
GO:0005031	IBA	-	tumor necrosis factor-activated receptor activity	-
GO:0005035	TAS	-	death receptor activity	9082980
GO:0005515	IPI	-	protein binding	17047155
GO:0008134	IPI	-	transcription factor binding	18165900
GO:0045569	NAS	-	TRAIL binding	9373179

GO ID	Evidence	Qualifier	GO_term	References
GO:0006915	NAS	-	apoptotic process	9311998
GO:0006919	TAS	-	activation of cysteine-type endopeptidase activity involved in apoptotic process	-
GO:0006954	IBA	-	inflammatory response	-
GO:0006955	IBA	-	immune response	-
GO:0007165	TAS	-	signal transduction	9082980
GO:0007166	TAS	-	cell surface receptor signaling pathway	-
GO:0007250	NAS	-	activation of NF-kappaB-inducing kinase activity	9430227
GO:0007275	IBA	-	multicellular organism development	-
GO:0008625	NAS	-	extrinsic apoptotic signaling pathway via death domain receptors	9311998
GO:0032496	IBA	-	response to lipopolysaccharide	-
GO:0033209	IEA	-	tumor necrosis factor-mediated signaling pathway	-
GO:0036462	IDA	-	TRAIL-activated apoptotic signaling pathway	21785459
GO:0042127	IBA	-	regulation of cell proliferation	-
GO:0042981	IBA	-	regulation of apoptotic process	-
GO:0042981	TAS	-	regulation of apoptotic process	-
GO:0050900	TAS	-	leukocyte migration	-
GO:0071260	IEP	-	cellular response to mechanical stimulus	19593445
GO:0097191	IDA	-	extrinsic apoptotic signaling pathway	21785459
GO:0097296	TAS	-	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	-
GO:1902041	TAS	-	regulation of extrinsic apoptotic signaling pathway via death domain receptors	-
GO:1902042	TAS	-	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	-

Gene Symbol	Interactant	Interaction ID	References	Description
TNFRSF10A	CASP8	114325	9325248	Affinity Capture-Western
TNFRSF10A	CASP8	107291	9325248	Affinity Capture-Western
TNFRSF10A	CASP10	114325	9325248	Affinity Capture-Western
TNFRSF10A	CASP10	107293	9325248	Affinity Capture-Western
TNFRSF10A	DAP3	113587	11376335	Affinity Capture-Western; Two-hybrid
TNFRSF10A	DAP3	114325	11376335	Affinity Capture-Western; Two-hybrid
TNFRSF10A	TRADD	114257	9430227	Affinity Capture-Western
TNFRSF10A	TRADD	114325	9430227	Affinity Capture-Western
TNFRSF10A	TNFSF10	114280	9082980	Affinity Capture-Western
TNFRSF10A	TNFSF10	114325	9082980	Affinity Capture-Western
TNFRSF10A	FADD	114325	9430227	Affinity Capture-Western
TNFRSF10A	FADD	114302	9430227	Affinity Capture-Western
CFLAR	TNFRSF10A	114364	9325248	Affinity Capture-Western
CFLAR	TNFRSF10A	114325	9325248	Affinity Capture-Western
BCL10	TNFRSF10A	114325	10400625	Two-hybrid
BCL10	TNFRSF10A	114429	10400625	Two-hybrid

AutismKB 2.0

Annotation Details for TNFRSF10A