AutismKB 2.0

Annotation Details for NRP1


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Basic Information Top
Gene Symbol:NRP1 ( BDCA4,CD304,DKFZp686A03134,DKFZp781F1414,NP1,NRP,VEGF165R )
Gene Full Name: neuropilin 1
Band: 10p11.22
Quick LinksEntrez ID:8829; OMIM: 602069; Uniprot ID:NRP1_HUMAN; ENSEMBL ID: ENSG00000099250; HGNC ID: 8004
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0002116NAS-semaphorin receptor complex19909241
GO:0005615IDA-extracellular space16502470
GO:0005769ISS-early endosome23639442
GO:0005829IDA-cytosol21245381
GO:0005883IEA-neurofilament-
GO:0005886IDA-plasma membrane21245381
GO:0005886TAS-plasma membrane-
GO:0005925IDA-focal adhesion21423176
GO:0009986IEA-cell surface-
GO:0016021IEA-integral component of membrane-
GO:0030424ISS-axon-
GO:0030426IEA-growth cone-
GO:0031410TAS-cytoplasmic vesicle21245381
GO:0043025IEA-neuronal cell body-
GO:0043235TAS-receptor complex21245381
GO:0097443ISS-sorting endosome23639442
GO ID Evidence Qualifier GO_term References
GO:0005021ISS-vascular endothelial growth factor-activated receptor activity-
GO:0005021NAS-vascular endothelial growth factor-activated receptor activity19909241
GO:0005515IPI-protein binding16763549
GO:0008201IEA-heparin binding-
GO:0015026TAS-coreceptor activity21245381
GO:0017154NAS-semaphorin receptor activity19909241
GO:0019838IPI-growth factor binding9529250
GO:0019838TAS-growth factor binding21245381
GO:0019955NAS-cytokine binding19909241
GO:0038085IPI-vascular endothelial growth factor binding24401374
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0001525IMP-angiogenesis23639442
GO:0001525ISS-angiogenesis24401374
GO:0001569ISS-branching involved in blood vessel morphogenesis24401374
GO:0001764ISS-neuron migration-
GO:0001938TAS-positive regulation of endothelial cell proliferation21245381
GO:0002040ISS-sprouting angiogenesis24401374
GO:0002042ISS-cell migration involved in sprouting angiogenesis-
GO:0007165TAS-signal transduction9288753
GO:0007267TAS-cell-cell signaling9288753
GO:0007411NAS-axon guidance19909241
GO:0007413IEA-axonal fasciculation-
GO:0009611IEA-response to wounding-
GO:0009887TAS-animal organ morphogenesis9529250
GO:0010595TAS-positive regulation of endothelial cell migration21245381
GO:0014911TAS-positive regulation of smooth muscle cell migration21245381
GO:0016358IEA-dendrite development-
GO:0021612IEA-facial nerve structural organization-
GO:0021637IEA-trigeminal nerve structural organization-
GO:0021649IEA-vestibulocochlear nerve structural organization-
GO:0021675ISS-nerve development-
GO:0021785IEA-branchiomotor neuron axon guidance-
GO:0021828IEA-gonadotrophin-releasing hormone neuronal migration to the hypothalamus-
GO:0031290ISS-retinal ganglion cell axon guidance-
GO:0035729IMP-cellular response to hepatocyte growth factor stimulus21245381
GO:0035767IMP-endothelial cell chemotaxis21245381
GO:0035924ISS-cellular response to vascular endothelial growth factor stimulus24401374
GO:0036486IEA-ventral trunk neural crest cell migration-
GO:0038190ISS-VEGF-activated neuropilin signaling pathway23639442
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0048008IMP-platelet-derived growth factor receptor signaling pathway21245381
GO:0048010IMP-vascular endothelial growth factor receptor signaling pathway21245381
GO:0048010TAS-vascular endothelial growth factor receptor signaling pathway-
GO:0048012IMP-hepatocyte growth factor receptor signaling pathway21245381
GO:0048842ISS-positive regulation of axon extension involved in axon guidance-
GO:0048843IEA-negative regulation of axon extension involved in axon guidance-
GO:0048844ISS-artery morphogenesis23639442
GO:0048846ISS-axon extension involved in axon guidance-
GO:0050731IMP-positive regulation of peptidyl-tyrosine phosphorylation21245381
GO:0050918ISS-positive chemotaxis-
GO:0060301TAS-positive regulation of cytokine activity21245381
GO:0060385ISS-axonogenesis involved in innervation-
GO:0060627TAS-regulation of vesicle-mediated transport21245381
GO:0060666IEA-dichotomous subdivision of terminal units involved in salivary gland branching-
GO:0060978ISS-angiogenesis involved in coronary vascular morphogenesis24401374
GO:0060982IEA-coronary artery morphogenesis-
GO:0061299ISS-retina vasculature morphogenesis in camera-type eye24401374
GO:0061441IEA-renal artery morphogenesis-
GO:0061549ISS-sympathetic ganglion development-
GO:0061551IEA-trigeminal ganglion development-
GO:0070374ISS-positive regulation of ERK1 and ERK2 cascade23639442
GO:0071526NAS-semaphorin-plexin signaling pathway19909241
GO:0071679ISS-commissural neuron axon guidance-
GO:0090259ISS-regulation of retinal ganglion cell axon guidance-
GO:0097102ISS-endothelial tip cell fate specification-
GO:0097374IEA-sensory neuron axon guidance-
GO:0097475ISS-motor neuron migration-
GO:0097490ISS-sympathetic neuron projection extension-
GO:0097491ISS-sympathetic neuron projection guidance-
GO:1901166ISS-neural crest cell migration involved in autonomic nervous system development-
GO:1901998IEA-toxin transport-
GO:1902285ISS-semaphorin-plexin signaling pathway involved in neuron projection guidance-
GO:1902287IEA-semaphorin-plexin signaling pathway involved in axon guidance-
GO:1902336ISS-positive regulation of retinal ganglion cell axon guidance-
GO:1902378IEA-VEGF-activated neuropilin signaling pathway involved in axon guidance-
GO:1902946ISS-protein localization to early endosome23639442
GO:1903375IEA-facioacoustic ganglion development-
GO:1904835IEA-dorsal root ganglion morphogenesis-
GO:1905040IEA-otic placode development-
GO:2001237IEA-negative regulation of extrinsic apoptotic signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NRP1PGF11124911986311 Reconstituted Complex
NRP1PGF11435611986311 Reconstituted Complex
NRP1VEGFA1143569529250 11986311 Affinity Capture-Western; Reconstituted Complex
NRP1VEGFA1132659529250 11986311 Affinity Capture-Western; Reconstituted Complex
NRP1VEGFB11435610409677 Reconstituted Complex
NRP1VEGFB11326610409677 Reconstituted Complex
SRRM1NRP111554416159877 Affinity Capture-MS
SRRM1NRP111435616159877 Affinity Capture-MS
Gene Symbol Interactant Interaction ID References Description
NRP1FGF121762715695515 NRP1 (Npn-1) interacts with FGF1. This interaction was modeled on a demonstrated interaction between rat NRP1 and human FGF1.
NRP1HGF21775515695515 NRP1 (Npn-1) interacts with HGF. This interaction was modeled on a demonstrated interaction between rat NRP1 and human HGF.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:106206
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030519-2'