AutismKB 2.0

Annotation Details for SYNGAP1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SYNGAP1 ( DKFZp761G1421,KIAA1938,MRD5,RASA1,RASA5,SYNGAP )
Gene Full Name: synaptic Ras GTPase activating protein 1
Band: 6p21.32
Quick LinksEntrez ID:8831; OMIM: 603384; Uniprot ID:SYGP1_HUMAN; ENSEMBL ID: ENSG00000197283; HGNC ID: 11497
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IBA-cytoplasm-
GO:0005829TAS-cytosol-
GO:0014069IEA-postsynaptic density-
GO:0031235IBA-intrinsic component of the cytoplasmic side of the plasma membrane-
GO:0043198IEA-dendritic shaft-
GO ID Evidence Qualifier GO_term References
GO:0005096IBA-GTPase activator activity-
GO:0017124IEA-SH3 domain binding-
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0007265IEA-Ras protein signal transduction-
GO:0007389IEA-pattern specification process-
GO:0008542IEA-visual learning-
GO:0016358IEA-dendrite development-
GO:0043113IEA-receptor clustering-
GO:0043408IEA-regulation of MAPK cascade-
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0046580IBA-negative regulation of Ras protein signal transduction-
GO:0046580ISS-negative regulation of Ras protein signal transduction-
GO:0048167ISS-regulation of synaptic plasticity-
GO:0048169IEA-regulation of long-term neuronal synaptic plasticity-
GO:0050771IEA-negative regulation of axonogenesis-
GO:0050803IEA-regulation of synapse structure or activity-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SYNGAP1DLG31143589581761 Affinity Capture-Western; Two-hybrid
SYNGAP1DLG31080859581761 Affinity Capture-Western; Two-hybrid
SYNGAP1DLG41143589581761 Two-hybrid
SYNGAP1DLG41080869581761 Two-hybrid
SYNGAP1ULK111435815014045 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SYNGAP1ULK111399615014045 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ULK2SYNGAP111435815014045 Reconstituted Complex
ULK2SYNGAP111505815014045 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
SYNGAP1SYNGAP1_3344T/C Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:3039785
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070222-2'