AutismKB 2.0

Annotation Details for SOCS2


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Basic Information Top
Gene Symbol:SOCS2 ( CIS2,Cish2,SOCS-2,SSI-2,SSI2,STATI2 )
Gene Full Name: suppressor of cytokine signaling 2
Band: 12q
Quick LinksEntrez ID:8835; OMIM: 605117; Uniprot ID:SOCS2_HUMAN; ENSEMBL ID: ENSG00000120833; HGNC ID: 19382
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IBA-cytoplasm-
GO:0005737NAS-cytoplasm9727029
GO:0005829TAS-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0004860IBA-protein kinase inhibitor activity-
GO:0005070TAS-SH3/SH2 adaptor activity9344848
GO:0005131NAS-growth hormone receptor binding12135564
GO:0005159IPI-insulin-like growth factor receptor binding9727029
GO:0005515IPI-protein binding11781573
GO:0008269IEA-JAK pathway signal transduction adaptor activity-
GO ID Evidence Qualifier GO_term References
GO:0001558NAS-regulation of cell growth9727029
GO:0006469IBA-negative regulation of protein kinase activity-
GO:0007259TAS-JAK-STAT cascade9266833
GO:0007595IEA-lactation-
GO:0009966NAS-regulation of signal transduction9727029
GO:0009967IEA-positive regulation of signal transduction-
GO:0016567IEA-protein ubiquitination-
GO:0019221IBA-cytokine-mediated signaling pathway-
GO:0032355IDA-response to estradiol12552091
GO:0032870IDA-cellular response to hormone stimulus12552091
GO:0040015IEA-negative regulation of multicellular organism growth-
GO:0043066TAS-negative regulation of apoptotic process9266833
GO:0043687TAS-post-translational protein modification-
GO:0045666IEA-positive regulation of neuron differentiation-
GO:0046426IBA-negative regulation of JAK-STAT cascade-
GO:0046627IBA-negative regulation of insulin receptor signaling pathway-
GO:0060396IDA-growth hormone receptor signaling pathway12552091
GO:0060749IEA-mammary gland alveolus development-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SOCS2EPOR11436211781573 15644415 16961462 Affinity Capture-Western; PCA; Reconstituted Complex; Two-hybrid
SOCS2EPOR10837111781573 15644415 16961462 Affinity Capture-Western; PCA; Reconstituted Complex; Two-hybrid
SOCS2GHR11436210585430 Reconstituted Complex
SOCS2GHR10895710585430 Reconstituted Complex
SOCS2IGF1R1143629727029 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SOCS2IGF1R1097019727029 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SOCS2PRLR11436210455112 Affinity Capture-Western
SOCS2PRLR11160310455112 Affinity Capture-Western
SOCS2PTK211436216189514 Two-hybrid
SOCS2PTK211171916189514 Two-hybrid
SOCS2SOCS111420317898043 Affinity Capture-Western
SOCS2SOCS111436217898043 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1201787
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041210-171'