AutismKB 2.0

Annotation Details for CFLAR


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Basic Information Top
Gene Symbol:CFLAR ( CASH,CASP8AP1,CLARP,Casper,FLAME,FLAME-1,FLAME1,FLIP,I-FLICE,MRIT,c-FLIP,c-FLIPL,c-FLIPR,c-FLIPS )
Gene Full Name: CASP8 and FADD-like apoptosis regulator
Band: 2q33.1
Quick LinksEntrez ID:8837; OMIM: 603599; Uniprot ID:CFLAR_HUMAN; ENSEMBL ID: ENSG00000003402; HGNC ID: 1876
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm18073330
GO:0005829TAS-cytosol-
GO:0031264IDA-death-inducing signaling complex21803845
GO:0031265IEA-CD95 death-inducing signaling complex-
GO:0045121IEA-membrane raft-
GO:0097342IDA-ripoptosome21737330
GO ID Evidence Qualifier GO_term References
GO:0002020IPI-protease binding9208847
GO:0005123IEA-death receptor binding-
GO:0005515IPI-protein binding9208847
GO:0008047IDA-enzyme activator activity9208847
GO:0032403IEA-protein complex binding-
GO:0097200IBA-cysteine-type endopeptidase activity involved in execution phase of apoptosis-
GO ID Evidence Qualifier GO_term References
GO:0006508IEA-proteolysis-
GO:0006915IMP-apoptotic process21737330
GO:0007519ISS-skeletal muscle tissue development-
GO:0010667IEA-negative regulation of cardiac muscle cell apoptotic process-
GO:0010976IEA-positive regulation of neuron projection development-
GO:0014732ISS-skeletal muscle atrophy-
GO:0014842ISS-regulation of skeletal muscle satellite cell proliferation-
GO:0014866ISS-skeletal myofibril assembly-
GO:0016032IEA-viral process-
GO:0032869IEA-cellular response to insulin stimulus-
GO:0033574IEA-response to testosterone-
GO:0043066TAS-negative regulation of apoptotic process9217161
GO:0043085IEA-positive regulation of catalytic activity-
GO:0043123IEP-positive regulation of I-kappaB kinase/NF-kappaB signaling12761501
GO:0043403ISS-skeletal muscle tissue regeneration-
GO:0051092ISS-positive regulation of NF-kappaB transcription factor activity-
GO:0060544IDA-regulation of necroptotic process21737330
GO:0070374IEA-positive regulation of ERK1 and ERK2 cascade-
GO:0071364IEA-cellular response to epidermal growth factor stimulus-
GO:0071392IEA-cellular response to estradiol stimulus-
GO:0071456IEA-cellular response to hypoxia-
GO:0071549IEA-cellular response to dexamethasone stimulus-
GO:0071732IEA-cellular response to nitric oxide-
GO:0072126IEA-positive regulation of glomerular mesangial cell proliferation-
GO:0097194IBA-execution phase of apoptosis-
GO:1901740ISS-negative regulation of myoblast fusion-
GO:1902041TAS-regulation of extrinsic apoptotic signaling pathway via death domain receptors-
GO:1902042IDA-negative regulation of extrinsic apoptotic signaling pathway via death domain receptors26582200
GO:1902042IMP-negative regulation of extrinsic apoptotic signaling pathway via death domain receptors18202225
GO:1902042TAS-negative regulation of extrinsic apoptotic signaling pathway via death domain receptors-
GO:1903055IEA-positive regulation of extracellular matrix organization-
GO:1903427IEA-negative regulation of reactive oxygen species biosynthetic process-
GO:1903845IEA-negative regulation of cellular response to transforming growth factor beta stimulus-
GO:1903944IEA-negative regulation of hepatocyte apoptotic process-
GO:2000347IEA-positive regulation of hepatocyte proliferation-
GO:2001237IDA-negative regulation of extrinsic apoptotic signaling pathway9208847
GO:2001237IMP-negative regulation of extrinsic apoptotic signaling pathway22266862
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CFLARFAS1068519208847 9325248 Affinity Capture-Western
CFLARFAS1143649208847 9325248 Affinity Capture-Western
CFLARBCL2L11143649326610 Affinity Capture-Western
CFLARBCL2L11070709326610 Affinity Capture-Western
CFLARCASP31143649208847 9326610 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CFLARCASP31072869208847 9326610 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CFLARCASP81143649208847 9228018 9289491 9326610 11741985 12215447 12887920 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CFLARCASP81072919208847 9228018 9289491 9326610 11741985 12215447 12887920 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CFLARCASP101143649228018 9289491 12887920 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CFLARCASP101072939228018 9289491 12887920 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CFLARRAF111436410837247 16537561 Affinity Capture-Western
CFLARRAF111183110837247 16537561 Affinity Capture-Western
CFLARTP5311436418559494 Affinity Capture-Western
CFLARTP5311301018559494 Affinity Capture-Western
CFLARTRAF11143649208847 10837247 Affinity Capture-Western
CFLARTRAF11130379208847 10837247 Affinity Capture-Western
CFLARTRAF21143649208847 10837247 Affinity Capture-Western
CFLARTRAF21130389208847 10837247 Affinity Capture-Western
CFLARTRAF311436410837247 Affinity Capture-Western
CFLARTRAF311303910837247 Affinity Capture-Western
CFLARUBC11436415886205 16246840 18559494 Affinity Capture-Western
CFLARUBC11316415886205 16246840 18559494 Affinity Capture-Western
CFLARRIPK111427410837247 11002417 Affinity Capture-Western
CFLARRIPK111436410837247 11002417 Affinity Capture-Western
CFLARRIPK21143649575181 Affinity Capture-Western
CFLARRIPK21143009575181 Affinity Capture-Western
CFLARFADD1143649208847 9228018 9326610 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CFLARFADD1143029208847 9228018 9326610 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CFLARTNFRSF10B1143649325248 11940602 Affinity Capture-Western
CFLARTNFRSF10B1143239325248 11940602 Affinity Capture-Western
CFLARTNFRSF10A1143649325248 Affinity Capture-Western
CFLARTNFRSF10A1143259325248 Affinity Capture-Western
CFLARCFLAR1143649228018 Two-hybrid
NOL3CFLAR1143649560245 Phenotypic Suppression
NOL3CFLAR1144779560245 Phenotypic Suppression
NOD1CFLAR11436410329646 Affinity Capture-Western
NOD1CFLAR11566410329646 Affinity Capture-Western
MAP3K14CFLAR11436411002417 Affinity Capture-Western
MAP3K14CFLAR11448711002417 Affinity Capture-Western
DEDD2CFLAR11436411741985 11965497 Affinity Capture-Western; Reconstituted Complex
DEDD2CFLAR12783811741985 11965497 Affinity Capture-Western; Reconstituted Complex
DEDDCFLAR11462711741985 11965497 Affinity Capture-Western; Reconstituted Complex
DEDDCFLAR11436411741985 11965497 Affinity Capture-Western; Reconstituted Complex
SF3B3CFLAR11436417353931 Affinity Capture-MS
SF3B3CFLAR11701617353931 Affinity Capture-MS
DOK2CFLAR11436417353931 Affinity Capture-MS
DOK2CFLAR11450817353931 Affinity Capture-MS
ITCHCFLAR11436418559494 Affinity Capture-Western
ITCHCFLAR12374718559494 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
CFLARBCL2L11959149326610 MRIT-alpha-1 interacts with BclXL. This interaction was modelled on a demonstrated interaction between human MRIT-alpha-1 and BclXL from an unspecified species.
CFLARCASP31957199326610 MRIT-beta-1 interacts with YAMA. This interaction was modelled on a demonstrated interaction between human MRIT-beta-1 and YAMA from an unspecified species.
CFLARCASP81957229326610 MRIT-beta-1 interacts with FLICE. This interaction was modelled on a demonstrated interaction between human MRIT-beta-1 and FLICE from an unspecified species.
CFLARCASP81959159326610 MRIT-alpha-1 interacts with FLICE. This interaction was modelled on a demonstrated interaction between human MRIT-alpha-1 and FLICE from an unspecified species.
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
CFLARrs2041765 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1336166
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030826-3'