AutismKB 2.0

Annotation Details for HDAC3


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Basic Information Top
Gene Symbol:HDAC3 ( HD3,RPD3,RPD3-2 )
Gene Full Name: histone deacetylase 3
Band: 5q31.3
Quick LinksEntrez ID:8841; OMIM: 605166; Uniprot ID:HDAC3_HUMAN; ENSEMBL ID: ENSG00000171720; HGNC ID: 4854
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000118TAS-histone deacetylase complex12711221
GO:0005634IDA-nucleus18326024
GO:0005634TAS-nucleus12711221
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm25190803
GO:0005737TAS-cytoplasm12711221
GO:0005794IDA-Golgi apparatus-
GO:0005829IDA-cytosol21030595
GO:0005876IDA-spindle microtubule18326024
GO:0005886IDA-plasma membrane-
GO:0017053IDA-transcriptional repressor complex11804585
GO ID Evidence Qualifier GO_term References
GO:0003682IDA-chromatin binding16569215
GO:0003714IDA-transcription corepressor activity16569215
GO:0003714IMP-transcription corepressor activity12628926
GO:0004407IMP-histone deacetylase activity16924111
GO:0004407TAS-histone deacetylase activity12711221
GO:0005515IPI-protein binding10898795
GO:0008134IPI-transcription factor binding16569215
GO:0008134TAS-transcription factor binding12711221
GO:0019899IPI-enzyme binding11641274
GO:0030332IPI-cyclin binding18417529
GO:0032041IEA-NAD-dependent histone deacetylase activity (H3-K14 specific)-
GO:0033558IDA-protein deacetylase activity17172643
GO:0042826IPI-histone deacetylase binding10869435
GO:0051059IPI-NF-kappaB binding17785205
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter16569215
GO:0000122IMP-negative regulation of transcription from RNA polymerase II promoter12628926
GO:0001934IDA-positive regulation of protein phosphorylation25190803
GO:0006325TAS-chromatin organization12711221
GO:0006351IEA-transcription, DNA-templated-
GO:0006476IDA-protein deacetylation17172643
GO:0007623TAS-circadian rhythm-
GO:0010832IMPNOTnegative regulation of myotube differentiation10983972
GO:0019216TAS-regulation of lipid metabolic process-
GO:0031647IDA-regulation of protein stability25190803
GO:0032008IMP-positive regulation of TOR signaling25190803
GO:0042993IDA-positive regulation of transcription factor import into nucleus25190803
GO:0043066TAS-negative regulation of apoptotic process10777477
GO:0045892IMP-negative regulation of transcription, DNA-templated16924111
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter25190803
GO:0046329IMP-negative regulation of JNK cascade11931768
GO:0051225IMP-spindle assembly18326024
GO:0070932IEA-histone H3 deacetylation-
GO:0071498IDA-cellular response to fluid shear stress25190803
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HDAC3PARP111436816204234 Affinity Capture-Western; Reconstituted Complex
HDAC3PARP110665216204234 Affinity Capture-Western; Reconstituted Complex
HDAC3AKT111436820026773 Affinity Capture-Western
HDAC3AKT110671020026773 Affinity Capture-Western
HDAC3AR11436812943985 Reconstituted Complex
HDAC3AR10686212943985 Reconstituted Complex
HDAC3CCND111436812048199 15558026 15713663 Affinity Capture-Western; Co-localization
HDAC3CCND110706712048199 15558026 15713663 Affinity Capture-Western; Co-localization
HDAC3RUNX211436815292260 18321663 Affinity Capture-Western; Reconstituted Complex
HDAC3RUNX210730815292260 18321663 Affinity Capture-Western; Reconstituted Complex
HDAC3RUNX111436816652147 Affinity Capture-Western
HDAC3RUNX110730916652147 Affinity Capture-Western
HDAC3RUNX1T110731011533236 15333839 Affinity Capture-Western
HDAC3RUNX1T111436811533236 15333839 Affinity Capture-Western
HDAC3CBFA2T311436811533236 12242670 Affinity Capture-Western
HDAC3CBFA2T310731111533236 12242670 Affinity Capture-Western
HDAC3CEBPD10748117910034 18619497 Affinity Capture-Western; Reconstituted Complex
HDAC3CEBPD11436817910034 18619497 Affinity Capture-Western; Reconstituted Complex
HDAC3KLF611436815917248 Affinity Capture-Western
HDAC3KLF610771115917248 Affinity Capture-Western
HDAC3CREBBP11436816528103 Affinity Capture-Western; Reconstituted Complex
HDAC3CREBBP10777716528103 Affinity Capture-Western; Reconstituted Complex
HDAC3CSNK2A110784115805470 Biochemical Activity
HDAC3CSNK2A111436815805470 Biochemical Activity
HDAC3CTBP111436811022042 Reconstituted Complex
HDAC3CTBP110786911022042 Reconstituted Complex
HDAC3DACH110797217182846 Affinity Capture-Western
HDAC3DACH111436817182846 Affinity Capture-Western
HDAC3DAXX10798510669754 Far Western
HDAC3DAXX11436810669754 Far Western
HDAC3EMD11436817620012 Affinity Capture-MS; Affinity Capture-Western
HDAC3EMD10832517620012 Affinity Capture-MS; Affinity Capture-Western
HDAC3EP30011436817158926 18542060 19279113 Affinity Capture-Western; Reconstituted Complex
HDAC3EP30010834717158926 18542060 19279113 Affinity Capture-Western; Reconstituted Complex
HDAC3ESR110840314722073 Co-localization
HDAC3ESR111436814722073 Co-localization
HDAC3ETV611436811439334 Affinity Capture-Western
HDAC3ETV610842111439334 Affinity Capture-Western
HDAC3EWSR110843120211142 Two-hybrid
HDAC3EWSR111436820211142 Two-hybrid
HDAC3GATA110889314668799 Affinity Capture-Western; Reconstituted Complex
HDAC3GATA111436814668799 Affinity Capture-Western; Reconstituted Complex
HDAC3GATA210889411567998 Affinity Capture-Western
HDAC3GATA211436811567998 Affinity Capture-Western
HDAC3GATA310889517075044 Affinity Capture-Western
HDAC3GATA311436817075044 Affinity Capture-Western
HDAC3GPS211436811931768 Affinity Capture-MS; Affinity Capture-Western
HDAC3GPS210913211931768 Affinity Capture-MS; Affinity Capture-Western
HDAC3GTF2I11436812239342 12393887 16943425 17970752 Affinity Capture-Western; Reconstituted Complex
HDAC3GTF2I10922412239342 12393887 16943425 17970752 Affinity Capture-Western; Reconstituted Complex
HDAC3HIF1A10933811641274 Reconstituted Complex
HDAC3HIF1A11436811641274 Reconstituted Complex
HDAC3HNF4A10941412205093 Reconstituted Complex
HDAC3HNF4A11436812205093 Reconstituted Complex
HDAC3HSPA410954011777905 Affinity Capture-Western
HDAC3HSPA411436811777905 Affinity Capture-Western
HDAC3HSPA811436812502735 Reconstituted Complex
HDAC3HSPA810954412502735 Reconstituted Complex
HDAC3IL1610981618097041 Affinity Capture-Western; Reconstituted Complex
HDAC3IL1611436818097041 Affinity Capture-Western; Reconstituted Complex
HDAC3INSM110985316569215 Affinity Capture-Western
HDAC3INSM111436816569215 Affinity Capture-Western
HDAC3JUN10992812853483 Affinity Capture-Western
HDAC3JUN11436812853483 Affinity Capture-Western
HDAC3SMAD711436815831498 15831516 Affinity Capture-Western
HDAC3SMAD711026715831498 15831516 Affinity Capture-Western
HDAC3MAGEA211027516847267 Affinity Capture-Western
HDAC3MAGEA211436816847267 Affinity Capture-Western
HDAC3MBD111032216432238 Affinity Capture-Western
HDAC3MBD111436816432238 Affinity Capture-Western
HDAC3MEF2D11037317158926 Affinity Capture-Western; Biochemical Activity
HDAC3MEF2D11436817158926 Affinity Capture-Western; Biochemical Activity
HDAC3ATXN311436817079677 Affinity Capture-Western; Reconstituted Complex
HDAC3ATXN311043317079677 Affinity Capture-Western; Reconstituted Complex
HDAC3MYC11069418483244 Affinity Capture-Western
HDAC3MYC11436818483244 Affinity Capture-Western
HDAC3NFATC111436819463978 Co-localization
HDAC3NFATC111084519463978 Co-localization
HDAC3NFKB111085712972430 15494311 Affinity Capture-Western; Co-localization
HDAC3NFKB111436812972430 15494311 Affinity Capture-Western; Co-localization
HDAC3NFKBIA11085916371367 Affinity Capture-Western
HDAC3NFKBIA11436816371367 Affinity Capture-Western
HDAC3CNOT211091016712523 Affinity Capture-Western
HDAC3CNOT211436816712523 Affinity Capture-Western
HDAC3PBX111436811046157 Affinity Capture-Western
HDAC3PBX111112011046157 Affinity Capture-Western
HDAC3PML11138411259576 Affinity Capture-Western; Reconstituted Complex
HDAC3PML11436811259576 Affinity Capture-Western; Reconstituted Complex
HDAC3PPA111436816186112 Affinity Capture-Western
HDAC3PPA111146016186112 Affinity Capture-Western
HDAC3PPARD11146311867749 12943985 Affinity Capture-Western; Reconstituted Complex
HDAC3PPARD11436811867749 12943985 Affinity Capture-Western; Reconstituted Complex
HDAC3PPARG11146412479814 12943985 Affinity Capture-Western; Reconstituted Complex
HDAC3PPARG11436812479814 12943985 Affinity Capture-Western; Reconstituted Complex
HDAC3PPP4C11152315805470 Affinity Capture-Western; Reconstituted Complex
HDAC3PPP4C11436815805470 Affinity Capture-Western; Reconstituted Complex
HDAC3MAPK1111436815356147 Far Western; Reconstituted Complex; Two-hybrid
HDAC3MAPK1111158615356147 Far Western; Reconstituted Complex; Two-hybrid
HDAC3PROX111161318948102 Affinity Capture-Western
HDAC3PROX111436818948102 Affinity Capture-Western
HDAC3RARA11436812943985 Reconstituted Complex
HDAC3RARA11184912943985 Reconstituted Complex
HDAC3RB111436810490602 10958676 12479814 Affinity Capture-Western
HDAC3RB111186010490602 10958676 12479814 Affinity Capture-Western
HDAC3RBBP411186311470869 Reconstituted Complex
HDAC3RBBP411436811470869 Reconstituted Complex
HDAC3RBL111186810490602 Affinity Capture-Western
HDAC3RBL111436810490602 Affinity Capture-Western
HDAC3RELA11436811533489 15192014 Affinity Capture-Western
HDAC3RELA11190211533489 15192014 Affinity Capture-Western
HDAC3RXRA11436812943985 Reconstituted Complex
HDAC3RXRA11216812943985 Reconstituted Complex
HDAC3SAFB11220116195251 Affinity Capture-Western
HDAC3SAFB11436816195251 Affinity Capture-Western
HDAC3SKI11238816987993 17621263 19032343 19341714 Affinity Capture-Western
HDAC3SKI11436816987993 17621263 19032343 19341714 Affinity Capture-Western
HDAC3SMARCA411248119081374 Affinity Capture-Western
HDAC3SMARCA411436819081374 Affinity Capture-Western
HDAC3SP111255016298343 Affinity Capture-Western
HDAC3SP111436816298343 Affinity Capture-Western
HDAC3SPI111436817621263 Affinity Capture-Western
HDAC3SPI111256617621263 Affinity Capture-Western
HDAC3SRC11259216532030 17699109 Affinity Capture-Western; Biochemical Activity
HDAC3SRC11436816532030 17699109 Affinity Capture-Western; Biochemical Activity
HDAC3SREBF211259918403372 Reconstituted Complex
HDAC3SREBF211436818403372 Reconstituted Complex
HDAC3SRF11260017158926 Affinity Capture-Western
HDAC3SRF11436817158926 Affinity Capture-Western
HDAC3SRY11261415297880 Reconstituted Complex
HDAC3SRY11436815297880 Reconstituted Complex
HDAC3STAT311265115653507 Affinity Capture-Western
HDAC3STAT311436815653507 Affinity Capture-Western
HDAC3SUV39H111270611788710 Affinity Capture-Western; Reconstituted Complex
HDAC3SUV39H111436811788710 Affinity Capture-Western; Reconstituted Complex
HDAC3SYK11271716288017 Affinity Capture-Western; Reconstituted Complex
HDAC3SYK11436816288017 Affinity Capture-Western; Reconstituted Complex
HDAC3CNTN211436816865259 Affinity Capture-Western
HDAC3CNTN211276316865259 Affinity Capture-Western
HDAC3TBL1X11436810809664 11931768 18202150 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
HDAC3TBL1X11277010809664 11931768 18202150 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
HDAC3TBX311278818245468 Affinity Capture-Western
HDAC3TBX311436818245468 Affinity Capture-Western
HDAC3TCF1911436815051733 Affinity Capture-Western
HDAC3TCF1911280115051733 Affinity Capture-Western
HDAC3TCP111436812502735 Affinity Capture-Western; Reconstituted Complex
HDAC3TCP111281012502735 Affinity Capture-Western; Reconstituted Complex
HDAC3THRA11436811889044 Affinity Capture-Western
HDAC3THRA11292311889044 Affinity Capture-Western
HDAC3NR2E111436817873065 Affinity Capture-Western
HDAC3NR2E111295617873065 Affinity Capture-Western
HDAC3TMPO11436816129885 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HDAC3TMPO11296716129885 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HDAC3NR2C111436811463856 12943985 14521922 19204783 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HDAC3NR2C111303311463856 12943985 14521922 19204783 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HDAC3NR2C211436812943985 Reconstituted Complex
HDAC3NR2C211303412943985 Reconstituted Complex
HDAC3UBC11436818655026 Affinity Capture-MS; Affinity Capture-Western
HDAC3UBC11316418655026 Affinity Capture-MS; Affinity Capture-Western
HDAC3VHL11436811641274 Reconstituted Complex
HDAC3VHL11326911641274 Reconstituted Complex
HDAC3XPO111436811779848 17141982 Affinity Capture-Western
HDAC3XPO111334811779848 17141982 Affinity Capture-Western
HDAC3YY11143689346952 11486036 17925399 18542060 18558095 18940814 19279113 Affinity Capture-Western; Reconstituted Complex
HDAC3YY11133609346952 11486036 17925399 18542060 18558095 18940814 19279113 Affinity Capture-Western; Reconstituted Complex
HDAC3ZFP3611436819738286 Affinity Capture-Western
HDAC3ZFP3611337019738286 Affinity Capture-Western
HDAC3ZBTB1611436815467736 Reconstituted Complex
HDAC3ZBTB1611349815467736 Reconstituted Complex
HDAC3ZNF14811350119583777 Affinity Capture-Western; Co-localization
HDAC3ZNF14811436819583777 Affinity Capture-Western; Co-localization
HDAC3MAFK11436818241676 Affinity Capture-Western
HDAC3MAFK11368818241676 Affinity Capture-Western
HDAC3NRIP111436817053781 Affinity Capture-Western; Two-hybrid
HDAC3NRIP111384317053781 Affinity Capture-Western; Two-hybrid
HDAC3HIST1H4A11436815832170 Biochemical Activity
HDAC3HIST1H4A11395515832170 Biochemical Activity
HDAC3NR0B211436815835920 Reconstituted Complex
HDAC3NR0B211401215835920 Reconstituted Complex
HDAC3GCM111409316528103 Affinity Capture-Western; Reconstituted Complex
HDAC3GCM111436816528103 Affinity Capture-Western; Reconstituted Complex
HDAC3SAP3011436816820529 Affinity Capture-Western
HDAC3SAP3011434616820529 Affinity Capture-Western
HDAC5HDAC311533110220385 10869435 11804585 11931768 Affinity Capture-Western
HDAC5HDAC311436810220385 10869435 11804585 11931768 Affinity Capture-Western
HDAC4HDAC311436810220385 10869435 11466315 11804585 18558095 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
HDAC4HDAC311510610220385 10869435 11466315 11804585 18558095 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
HDAC9HDAC311436810655483 12590135 Affinity Capture-Western; Reconstituted Complex
HDAC9HDAC311508310655483 12590135 Affinity Capture-Western; Reconstituted Complex
NCOR2HDAC311436810809664 10860984 10944117 11013263 11804585 12205093 12502735 12628926 14527417 15837933 16481466 16924111 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-purification; Reconstituted Complex
NCOR2HDAC311497410809664 10860984 10944117 11013263 11804585 12205093 12502735 12628926 14527417 15837933 16481466 16924111 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-purification; Reconstituted Complex
NCOR1HDAC311436810860984 10944117 11013263 11466315 11804585 11931768 12628926 14527417 14722073 16195251 16917504 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-localization; Co-purification; Reconstituted Complex; Two-hybrid
NCOR1HDAC311497310860984 10944117 11013263 11466315 11804585 11931768 12628926 14527417 14722073 16195251 16917504 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-localization; Co-purification; Reconstituted Complex; Two-hybrid
BCORHDAC311436810898795 Affinity Capture-Western
BCORHDAC312022810898795 Affinity Capture-Western
HDAC7HDAC311436811466315 Affinity Capture-Western; Reconstituted Complex
HDAC7HDAC311961311466315 Affinity Capture-Western; Reconstituted Complex
HIF1ANHDAC311436811641274 Reconstituted Complex
HIF1ANHDAC312079411641274 Reconstituted Complex
HRHDAC311436811641275 12403844 Affinity Capture-Western
HRHDAC312091711641275 12403844 Affinity Capture-Western
HDAC3HDAC311436811779848 Affinity Capture-Western; Reconstituted Complex
HDAC10HDAC311436811861901 Affinity Capture-Western
HDAC10HDAC312381811861901 Affinity Capture-Western
TBL1XR1HDAC311436811931768 18202150 Affinity Capture-MS; Affinity Capture-Western
TBL1XR1HDAC312283411931768 18202150 Affinity Capture-MS; Affinity Capture-Western
IKZF1HDAC311436812015313 Affinity Capture-Western
IKZF1HDAC311560412015313 Affinity Capture-Western
TAB2HDAC311436812150997 Affinity Capture-Western; Reconstituted Complex
TAB2HDAC311674012150997 Affinity Capture-Western; Reconstituted Complex
GTF2IRD1HDAC311436812239342 16055724 Affinity Capture-Western
GTF2IRD1HDAC311493912239342 16055724 Affinity Capture-Western
CCT5HDAC311660312502735 Reconstituted Complex
CCT5HDAC311436812502735 Reconstituted Complex
LCORHDAC311436812535528 Affinity Capture-Western; Reconstituted Complex
LCORHDAC312409312535528 Affinity Capture-Western; Reconstituted Complex
ZBTB33HDAC311436814527417 Affinity Capture-MS; Affinity Capture-Western
ZBTB33HDAC311532714527417 Affinity Capture-MS; Affinity Capture-Western
PHB2HDAC311436815140878 Reconstituted Complex
PHB2HDAC311645915140878 Reconstituted Complex
ANKRD11HDAC311888815184363 Affinity Capture-Western; Reconstituted Complex
ANKRD11HDAC311436815184363 Affinity Capture-Western; Reconstituted Complex
THAP7HDAC311436815561719 Affinity Capture-Western; Reconstituted Complex
THAP7HDAC312329815561719 Affinity Capture-Western; Reconstituted Complex
KDM4AHDAC311503515927959 Affinity Capture-Western
KDM4AHDAC311436815927959 Affinity Capture-Western
SAFB2HDAC311436816195251 Affinity Capture-Western
SAFB2HDAC311502216195251 Affinity Capture-Western
CBFA2T2HDAC311436816227606 Affinity Capture-Western
CBFA2T2HDAC311458616227606 Affinity Capture-Western
PRAM1HDAC311436816432238 16730330 Affinity Capture-Western
PRAM1HDAC312389416432238 16730330 Affinity Capture-Western
SAP30LHDAC311436816820529 Affinity Capture-Western
SAP30LHDAC312280816820529 Affinity Capture-Western
REPIN1HDAC311436816924111 Affinity Capture-Western
REPIN1HDAC311892716924111 Affinity Capture-Western
GMNNHDAC311436816924111 Affinity Capture-Western
GMNNHDAC311924616924111 Affinity Capture-Western
KAT2BHDAC311436817158926 Affinity Capture-Western; Reconstituted Complex
KAT2BHDAC311437517158926 Affinity Capture-Western; Reconstituted Complex
PAPOLAHDAC311436817172643 Affinity Capture-Western
PAPOLAHDAC311611917172643 Affinity Capture-Western
NUDT21HDAC311436817172643 Affinity Capture-Western
NUDT21HDAC311623717172643 Affinity Capture-Western
BRMS1HDAC311436817227585 Reconstituted Complex
BRMS1HDAC311737917227585 Reconstituted Complex
SF3B1HDAC311436817353931 Affinity Capture-MS
SF3B1HDAC311701717353931 Affinity Capture-MS
ANKRD12HDAC311436818377363 Reconstituted Complex
ANKRD12HDAC311685718377363 Reconstituted Complex
RBM15HDAC311436818667423 Affinity Capture-Western
RBM15HDAC312229318667423 Affinity Capture-Western
ZBTB7AHDAC311948819244234 Affinity Capture-Western
ZBTB7AHDAC311436819244234 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
HDAC3CSNK2A125854315805470 CSNK2A1 (CK2) phosphorylates HDAC3.
HDAC3GTF2I18545212239342 HDAC3 interacts with TFII-I. This interaction was modeled on a demonstrated interaction between HDAC3 and TFII-I isoforms both from unspecified species.
Gene Symbol Interactant Interaction ID References Description
HDAC3CBFA2T30895012242670 -
HDAC3CBFA2T30484712242670 -
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
HDAC3rs2530223 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1343091
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-847'