AutismKB 2.0

Annotation Details for CDK5R1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CDK5R1 ( CDK5P35,CDK5R,MGC33831,NCK5A,p23,p25,p35,p35nck5a )
Gene Full Name: cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Band: 17q11.2
Quick LinksEntrez ID:8851; OMIM: 603460; Uniprot ID:CD5R1_HUMAN; ENSEMBL ID: ENSG00000176749; HGNC ID: 1775
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634ISS-nucleus-
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005737ISS-cytoplasm-
GO:0005829TAS-cytosol-
GO:0005886TAS-plasma membrane-
GO:0014069ISS-postsynaptic density-
GO:0016020ISS-membrane-
GO:0016533IEA-cyclin-dependent protein kinase 5 holoenzyme complex-
GO:0030424ISS-axon-
GO:0030425ISS-dendrite-
GO:0030426ISS-growth cone-
GO:0031594ISS-neuromuscular junction-
GO:0043025ISS-neuronal cell body-
GO:0043197ISS-dendritic spine-
GO:0043231IDA-intracellular membrane-bounded organelle-
GO:0043292ISS-contractile fiber-
GO:0048471IDA-perinuclear region of cytoplasm12832520
GO ID Evidence Qualifier GO_term References
GO:0004672TAS-protein kinase activity7592934
GO:0005509ISS-calcium ion binding-
GO:0005515IPI-protein binding10721722
GO:0016301ISS-kinase activity-
GO:0016534IEA-cyclin-dependent protein kinase 5 activator activity-
GO:0019901IPI-protein kinase binding12832520
GO:0043539IDA-protein serine/threonine kinase activator activity12832520
GO:0043539ISS-protein serine/threonine kinase activator activity-
GO:0045296ISS-cadherin binding-
GO:0046875IEA-ephrin receptor binding-
GO ID Evidence Qualifier GO_term References
GO:0000079TAS-regulation of cyclin-dependent protein serine/threonine kinase activity7592934
GO:0001764ISS-neuron migration-
GO:0007158ISS-neuron cell-cell adhesion-
GO:0007213ISS-G-protein coupled acetylcholine receptor signaling pathway-
GO:0007411ISS-axon guidance-
GO:0007413ISS-axonal fasciculation-
GO:0007420ISS-brain development-
GO:0007420NAS-brain development10915792
GO:0008283TAS-cell proliferation8090221
GO:0009790IEA-embryo development-
GO:0016241NAS-regulation of macroautophagy21499257
GO:0018105IDA-peptidyl-serine phosphorylation12832520
GO:0018107IDA-peptidyl-threonine phosphorylation12832520
GO:0021549IEA-cerebellum development-
GO:0021722IEA-superior olivary nucleus maturation-
GO:0021766IEA-hippocampus development-
GO:0021819IEA-layer formation in cerebral cortex-
GO:0030182ISS-neuron differentiation-
GO:0030517IEA-negative regulation of axon extension-
GO:0031175ISS-neuron projection development-
GO:0032956IEA-regulation of actin cytoskeleton organization-
GO:0035235ISS-ionotropic glutamate receptor signaling pathway-
GO:0042501IEA-serine phosphorylation of STAT protein-
GO:0043525ISS-positive regulation of neuron apoptotic process-
GO:0045664NAS-regulation of neuron differentiation10721722
GO:0045892IMP-negative regulation of transcription, DNA-templated20357208
GO:0048013ISS-ephrin receptor signaling pathway-
GO:0048511IEA-rhythmic process-
GO:0061001ISS-regulation of dendritic spine morphogenesis-
GO:0070507IEA-regulation of microtubule cytoskeleton organization-
GO:0071158IEA-positive regulation of cell cycle arrest-
GO:0071902IEA-positive regulation of protein serine/threonine kinase activity-
GO:0090314IEA-positive regulation of protein targeting to membrane-
GO:1901796TAS-regulation of signal transduction by p53 class mediator-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CDK5R1ACTN111437612223541 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CDK5R1ACTN110660212223541 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CDK5R1AMPH10677011113134 Affinity Capture-Western; Reconstituted Complex
CDK5R1AMPH11437611113134 Affinity Capture-Western; Reconstituted Complex
CDK5R1CAMK2A11437612223541 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CDK5R1CAMK2A10726512223541 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CDK5R1CDK510745511389014 11583627 17591690 Affinity Capture-Western; Co-crystal Structure
CDK5R1CDK511437611389014 11583627 17591690 Affinity Capture-Western; Co-crystal Structure
CDK5R1CTNNB110788011168528 Affinity Capture-Western; Reconstituted Complex
CDK5R1CTNNB111437611168528 Affinity Capture-Western; Reconstituted Complex
CDK5R1HDAC110931519081376 Affinity Capture-Western
CDK5R1HDAC111437619081376 Affinity Capture-Western
CDK5R1CDK1611115412084709 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CDK5R1CDK1611437612084709 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CDK5R1SET11437611741927 Affinity Capture-Western; Reconstituted Complex
CDK5R1SET11231611741927 Affinity Capture-Western; Reconstituted Complex
CDK5RAP1CDK5R111437610915792 Reconstituted Complex
CDK5RAP1CDK5R111966110915792 Reconstituted Complex
CDK5RAP2CDK5R112087310915792 Reconstituted Complex
CDK5RAP2CDK5R111437610915792 Reconstituted Complex
CDK5RAP3CDK5R112321310915792 Reconstituted Complex
CDK5RAP3CDK5R111437610915792 Reconstituted Complex
TSC22D4CDK5R111437616189514 Two-hybrid
TSC22D4CDK5R112356316189514 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
CDK5R1rs735555 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
CDK5R1rs735555 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:101764
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040718-220'