AutismKB 2.0

Annotation Details for ARHGEF7


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Basic Information Top
Gene Symbol:ARHGEF7 ( BETA-PIX,COOL-1,COOL1,DKFZp686C12170,DKFZp761K1021,KIAA0142,KIAA0412,Nbla10314,P50,P50BP,P85,P85COOL1,P85SPR,PAK3,PIXB )
Gene Full Name: Rho guanine nucleotide exchange factor (GEF) 7
Band: 13q34
Quick LinksEntrez ID:8874; OMIM: 605477; Uniprot ID:ARHG7_HUMAN; ENSEMBL ID: ENSG00000102606; HGNC ID: 15607
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000322IEA-storage vacuole-
GO:0001726IEA-ruffle-
GO:0005829TAS-cytosol-
GO:0005886IEA-plasma membrane-
GO:0005925IDA-focal adhesion21423176
GO:0005938IEA-cell cortex-
GO:0030027ISS-lamellipodium-
GO:0043005IDA-neuron projection21048939
GO:0043025IDA-neuronal cell body21048939
GO:0043234IDA-protein complex11864573
GO ID Evidence Qualifier GO_term References
GO:0005085EXP-guanyl-nucleotide exchange factor activity12695502
GO:0005085IDA-guanyl-nucleotide exchange factor activity21048939
GO:0005085TAS-guanyl-nucleotide exchange factor activity-
GO:0005089TAS-Rho guanyl-nucleotide exchange factor activity-
GO:0005515IPI-protein binding11864573
GO:0019901IPI-protein kinase binding21048939
GO ID Evidence Qualifier GO_term References
GO:0002244IEA-hematopoietic progenitor cell differentiation-
GO:0007030IMP-Golgi organization25500533
GO:0007165TAS-signal transduction9659915
GO:0007399IEA-nervous system development-
GO:0010763IDA-positive regulation of fibroblast migration21423176
GO:0030032ISS-lamellipodium assembly-
GO:0032092IEA-positive regulation of protein binding-
GO:0035023IEA-regulation of Rho protein signal transduction-
GO:0035556IEA-intracellular signal transduction-
GO:0042059TAS-negative regulation of epidermal growth factor receptor signaling pathway-
GO:0043065IMP-positive regulation of apoptotic process19041750
GO:0043065TAS-positive regulation of apoptotic process-
GO:0043547IDA-positive regulation of GTPase activity21048939
GO:0043547IMP-positive regulation of GTPase activity21423176
GO:0048013TAS-ephrin receptor signaling pathway-
GO:0048041IDA-focal adhesion assembly21423176
GO:0051056TAS-regulation of small GTPase mediated signal transduction-
GO:0060124IEA-positive regulation of growth hormone secretion-
GO:1900026IMP-positive regulation of substrate adhesion-dependent cell spreading21423176
GO:1904424IMP-regulation of GTP binding25500533
GO:2000394IMP-positive regulation of lamellipodium morphogenesis21423176
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ARHGEF7CBL11439312935897 14505571 16407834 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ARHGEF7CBL10731512935897 14505571 16407834 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ARHGEF7CDC4211439314505571 Affinity Capture-Western; Reconstituted Complex
ARHGEF7CDC4210743314505571 Affinity Capture-Western; Reconstituted Complex
ARHGEF7PAK111439311157752 16407834 20936779 Affinity Capture-Western; Two-hybrid
ARHGEF7PAK111109511157752 16407834 20936779 Affinity Capture-Western; Two-hybrid
ARHGEF7PAK31143939726964 Two-hybrid
ARHGEF7PAK31110999726964 Two-hybrid
GIT1ARHGEF711439310428811 12473661 Affinity Capture-Western; Two-hybrid
GIT1ARHGEF711878910428811 12473661 Affinity Capture-Western; Two-hybrid
PPM1EARHGEF711439311864573 Reconstituted Complex
PPM1EARHGEF711651511864573 Reconstituted Complex
PPM1FARHGEF711439311864573 Reconstituted Complex
PPM1FARHGEF711500511864573 Reconstituted Complex
SHANK2ARHGEF711439312626503 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SHANK2ARHGEF711659812626503 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SHANK1ARHGEF711439312626503 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SHANK1ARHGEF711917112626503 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SHANK3ARHGEF711439312626503 Affinity Capture-Western; Two-hybrid
SHANK3ARHGEF712448712626503 Affinity Capture-Western; Two-hybrid
TUBB3ARHGEF711439316169070 Two-hybrid
TUBB3ARHGEF711565416169070 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
ARHGEF7CDC4219709615649357 ARHGEF7 (p85Cool-1) interacts with Cdc42.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1860493
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041212-49'