AutismKB 2.0

Annotation Details for EIF2B5


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Basic Information Top
Gene Symbol:EIF2B5 ( CACH,CLE,EIF-2B,EIF2Bepsilon,LVWM )
Gene Full Name: eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
Band: 3q27.1
Quick LinksEntrez ID:8893; OMIM: 603945; Uniprot ID:EI2BE_HUMAN; ENSEMBL ID: ENSG00000145191; HGNC ID: 3261
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDANOTnucleus12426392
GO:0005634ISS-nucleus-
GO:0005737IDA-cytoplasm11323413
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005851IDA-eukaryotic translation initiation factor 2B complex11323413
GO ID Evidence Qualifier GO_term References
GO:0003743IDAcontributes_totranslation initiation factor activity16289705
GO:0003743NAS-translation initiation factor activity8688466
GO:0005085IDAcontributes_toguanyl-nucleotide exchange factor activity11323413
GO:0005085IMP-guanyl-nucleotide exchange factor activity15054402
GO:0005085ISS-guanyl-nucleotide exchange factor activity-
GO:0005515IPI-protein binding10481074
GO:0031369ISS-translation initiation factor binding-
GO ID Evidence Qualifier GO_term References
GO:0001541IMP-ovarian follicle development15507143
GO:0006413IDA-translational initiation16289705
GO:0007568IEA-aging-
GO:0009408IMP-response to heat15723074
GO:0009408ISS-response to heat-
GO:0009408TAS-response to heat12499492
GO:0009749ISS-response to glucose-
GO:0010226IEA-response to lithium ion-
GO:0014002IMP-astrocyte development15723074
GO:0014003IMP-oligodendrocyte development15217090
GO:0021766IEA-hippocampus development-
GO:0032057ISS-negative regulation of translational initiation in response to stress-
GO:0034976IMP-response to endoplasmic reticulum stress16041584
GO:0035690IDA-cellular response to drug8626696
GO:0042552IMP-myelination14566705
GO:0043065IEA-positive regulation of apoptotic process-
GO:0043434ISS-response to peptide hormone-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0045948ISS-positive regulation of translational initiation-
GO:0048708IMP-astrocyte differentiation15723074
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
EIF2B5EIF2B111441010858531 17353931 Affinity Capture-MS; Reconstituted Complex
EIF2B5EIF2B110828610858531 17353931 Affinity Capture-MS; Reconstituted Complex
EIF2B5EIF2B411440710858531 Reconstituted Complex
EIF2B5EIF2B411441010858531 Reconstituted Complex
EIF2B5EIF2B311441010858531 Reconstituted Complex
EIF2B5EIF2B311440810858531 Reconstituted Complex
EIF2B5EIF2B211441010858531 Reconstituted Complex
EIF2B5EIF2B211440910858531 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
EIF2B5rs7614305, rs865808 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:2446176
  • Data Attributes: HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-5364'