AutismKB 2.0

Annotation Details for CCNB1


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Basic Information Top
Gene Symbol:CCNB1 ( CCNB )
Gene Full Name: cyclin B1
Band: 5q13.2
Quick LinksEntrez ID:891; OMIM: 123836; Uniprot ID:CCNB1_HUMAN; ENSEMBL ID: ENSG00000134057; HGNC ID: 1579
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000922IDA-spindle pole18195732
GO:0000942IDA-condensed nuclear chromosome outer kinetochore18195732
GO:0005634IDA-nucleus11331587
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm11331587
GO:0005759IDAcolocalizes_withmitochondrial matrix24746669
GO:0005813IDA-centrosome12524548
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0016020IEA-membrane-
GO:0097125IDA-cyclin B1-CDK1 complex24746669
GO ID Evidence Qualifier GO_term References
GO:0004693TAS-cyclin-dependent protein serine/threonine kinase activity-
GO:0005113IPI-patched binding11331587
GO:0005515IPI-protein binding8756624
GO:0019901IPI-protein kinase binding12524548
GO:0035173IEA-histone kinase activity-
GO:0061575IDA-cyclin-dependent protein serine/threonine kinase activator activity24746669
GO ID Evidence Qualifier GO_term References
GO:0000086TAS-G2/M transition of mitotic cell cycle-
GO:0001556IEA-oocyte maturation-
GO:0001701IEA-in utero embryonic development-
GO:0001933IEA-negative regulation of protein phosphorylation-
GO:0006461IEA-protein complex assembly-
GO:0006977TAS-DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-
GO:0007052IMP-mitotic spindle organization18195732
GO:0007077TAS-mitotic nuclear envelope disassembly-
GO:0007080IMP-mitotic metaphase plate congression18195732
GO:0007283IEA-spermatogenesis-
GO:0009612IEA-response to mechanical stimulus-
GO:0010629IEA-negative regulation of gene expression-
GO:0031145TAS-anaphase-promoting complex-dependent catabolic process-
GO:0031442IEA-positive regulation of mRNA 3'-end processing-
GO:0031662IDA-positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle24746669
GO:0033129IEA-positive regulation of histone phosphorylation-
GO:0042246IEA-tissue regeneration-
GO:0042493IEA-response to drug-
GO:0042787TAS-protein ubiquitination involved in ubiquitin-dependent protein catabolic process-
GO:0045931IMP-positive regulation of mitotic cell cycle18195732
GO:0046680IEA-response to DDT-
GO:0048146IEA-positive regulation of fibroblast proliferation-
GO:0048565IEA-digestive tract development-
GO:0051301IEA-cell division-
GO:0051436TAS-negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle-
GO:0051437TAS-positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition-
GO:0051439TAS-regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle-
GO:0051726TAS-regulation of cell cycle-
GO:0051987IMP-positive regulation of attachment of spindle microtubules to kinetochore18195732
GO:0055015IEA-ventricular cardiac muscle cell development-
GO:0060045IEA-positive regulation of cardiac muscle cell proliferation-
GO:0060623IEA-regulation of chromosome condensation-
GO:0071283IEA-cellular response to iron(III) ion-
GO:0071398IEA-cellular response to fatty acid-
GO:0071407IEA-cellular response to organic cyclic compound-
GO:0071456IEA-cellular response to hypoxia-
GO:0090266IMP-regulation of mitotic cell cycle spindle assembly checkpoint18195732
GO:1905448IDA-positive regulation of mitochondrial ATP synthesis coupled electron transport24746669
GO:2000775IEA-histone H3-S10 phosphorylation involved in chromosome condensation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CCNB1BRCA11073329244350 Reconstituted Complex
CCNB1BRCA11071409244350 Reconstituted Complex
CDC25ACCNB11074281836978 Affinity Capture-Western
CDC25ACCNB11073321836978 Affinity Capture-Western
CDK1CCNB11073322570636 9247342 9891079 10716937 10973963 16159883 16784539 17679094 Affinity Capture-Western; Reconstituted Complex
CDK1CCNB11074202570636 9247342 9891079 10716937 10973963 16159883 16784539 17679094 Affinity Capture-Western; Reconstituted Complex
HIST1H1ACCNB11092759247342 Affinity Capture-Western
HIST1H1ACCNB11073329247342 Affinity Capture-Western
CDK2CCNB11074529891079 Affinity Capture-Western
CDK2CCNB11073329891079 Affinity Capture-Western
TGFBR2CCNB11129069926943 Reconstituted Complex
TGFBR2CCNB11073329926943 Reconstituted Complex
GADD45ACCNB110801410362260 12124778 Reconstituted Complex
GADD45ACCNB110733210362260 12124778 Reconstituted Complex
HERC5CCNB111936510581175 Reconstituted Complex
HERC5CCNB110733210581175 Reconstituted Complex
CCNFCCNB110733210716937 Affinity Capture-Western
CCNFCCNB110733910716937 Affinity Capture-Western
CDC25CCCNB110733210864927 Reconstituted Complex
CDC25CCCNB110743010864927 Reconstituted Complex
UBCCCNB111316412097298 15256223 16009132 Affinity Capture-Western
UBCCCNB110733212097298 15256223 16009132 Affinity Capture-Western
CDC27CCNB110733212097298 16479161 Affinity Capture-Western
CDC27CCNB110743112097298 16479161 Affinity Capture-Western
GADD45GCCNB111611712124778 Reconstituted Complex
GADD45GCCNB110733212124778 Reconstituted Complex
GADD45BCCNB111070112124778 Reconstituted Complex
GADD45BCCNB110733212124778 Reconstituted Complex
RALBP1CCNB111613112775724 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RALBP1CCNB110733212775724 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FOXM1CCNB110733215024056 Affinity Capture-Western
FOXM1CCNB110859415024056 Affinity Capture-Western
ZC3HC1CCNB111959216009132 17389604 Affinity Capture-Western; Reconstituted Complex
ZC3HC1CCNB110733216009132 17389604 Affinity Capture-Western; Reconstituted Complex
CDKN1ACCNB110733216082198 17679094 Affinity Capture-Western; Reconstituted Complex
CDKN1ACCNB110746016082198 17679094 Affinity Capture-Western; Reconstituted Complex
MGMTCCNB111041116226712 Affinity Capture-Western
MGMTCCNB110733216226712 Affinity Capture-Western
SETCCNB110733216474839 Affinity Capture-Western
SETCCNB111231616474839 Affinity Capture-Western
GAPDHCCNB110886816474839 Affinity Capture-Western; Reconstituted Complex
GAPDHCCNB110733216474839 Affinity Capture-Western; Reconstituted Complex
CDC14ACCNB111412616784539 Affinity Capture-Western
CDC14ACCNB110733216784539 Affinity Capture-Western
UBQLN1CCNB111900716799550 Reconstituted Complex
UBQLN1CCNB110733216799550 Reconstituted Complex
PSMD4CCNB110733216799550 Reconstituted Complex
PSMD4CCNB111168316799550 Reconstituted Complex
RAD23ACCNB111182316799550 Reconstituted Complex
RAD23ACCNB110733216799550 Reconstituted Complex
TSPYL2CCNB112203418591933 Affinity Capture-Western; Reconstituted Complex
TSPYL2CCNB110733218591933 Affinity Capture-Western; Reconstituted Complex
Gene Symbol Interactant Interaction ID References Description
GADD45BCCNB118337912124778 Cyclin B1 interacts with Gadd45b. This interaction was modeled on a demonstrated interaction between human Cyclin B1 and Gadd45b from an unspecified species.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:88302
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-000406-10'