AutismKB 2.0

Annotation Details for WASF1


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Basic Information Top
Gene Symbol:WASF1 ( FLJ31482,KIAA0269,SCAR1,WAVE,WAVE1 )
Gene Full Name: WAS protein family, member 1
Band: 6q21
Quick LinksEntrez ID:8936; OMIM: 605035; Uniprot ID:WASF1_HUMAN; ENSEMBL ID: ENSG00000112290; HGNC ID: 12732
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005741IEA-mitochondrial outer membrane-
GO:0005856TAS-cytoskeleton10970852
GO:0005925IEA-focal adhesion-
GO:0015629TAS-actin cytoskeleton9843499
GO:0030027IEA-lamellipodium-
GO:0031209IMP-SCAR complex21107423
GO:0045202IEA-synapse-
GO ID Evidence Qualifier GO_term References
GO:0003779IEA-actin binding-
GO:0005515IPI-protein binding9843499
GO:0032403IMP-protein complex binding21107423
GO:0048365IMPcontributes_toRac GTPase binding21107423
GO ID Evidence Qualifier GO_term References
GO:0006461NAS-protein complex assembly10381382
GO:0006898ISS-receptor-mediated endocytosis-
GO:0006928TAS-movement of cell or subcellular component2775266
GO:0016601IMP-Rac protein signal transduction21107423
GO:0030041TAS-actin filament polymerization9843499
GO:0051388IEA-positive regulation of neurotrophin TRK receptor signaling pathway-
GO:0072673IEA-lamellipodium morphogenesis-
GO:0097484IEA-dendrite extension-
GO:1990416ISS-cellular response to brain-derived neurotrophic factor stimulus-
GO:2000601IMP-positive regulation of Arp2/3 complex-mediated actin nucleation21107423
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
WASF1PFN11112379843499 Affinity Capture-Western; Far Western
WASF1PFN11144499843499 Affinity Capture-Western; Far Western
ARHGEF2WASF11146189843499 Affinity Capture-Western
ARHGEF2WASF11144499843499 Affinity Capture-Western
BAIAP2WASF111444911130076 Far Western; Reconstituted Complex; Two-hybrid
BAIAP2WASF111572111130076 Far Western; Reconstituted Complex; Two-hybrid
DNMBPWASF111444914506234 Affinity Capture-MS
DNMBPWASF111686914506234 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1890563
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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