AutismKB 2.0

Annotation Details for BTRC


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Basic Information Top
Gene Symbol:BTRC ( BETA-TRCP,FBW1A,FBXW1,FBXW1A,FWD1,MGC4643,bTrCP,bTrCP1,betaTrCP )
Gene Full Name: beta-transducin repeat containing
Band: 10q24.32
Quick LinksEntrez ID:8945; OMIM: 603482; Uniprot ID:FBW1A_HUMAN; ENSEMBL ID: ENSG00000166167; HGNC ID: 1144
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654TAS-nucleoplasm-
GO:0005829TAS-cytosol-
GO:0019005IDA-SCF ubiquitin ligase complex12820959
GO ID Evidence Qualifier GO_term References
GO:0004842EXP-ubiquitin-protein transferase activity11158290
GO:0004842IDAcontributes_toubiquitin-protein transferase activity15448698
GO:0004842TAS-ubiquitin-protein transferase activity-
GO:0005515IPI-protein binding9859996
GO:0008013IDA-beta-catenin binding12820959
GO:0016874IEA-ligase activity-
GO:0045309IEA-protein phosphorylated amino acid binding-
GO:0046983IEA-protein dimerization activity-
GO:0061630IDAcontributes_toubiquitin protein ligase activity12820959
GO ID Evidence Qualifier GO_term References
GO:0000086TAS-G2/M transition of mitotic cell cycle-
GO:0000209IDA-protein polyubiquitination12820959
GO:0000209IMP-protein polyubiquitination12820959
GO:0000209TAS-protein polyubiquitination-
GO:0002223TAS-stimulatory C-type lectin receptor signaling pathway-
GO:0006470ISS-protein dephosphorylation-
GO:0006511IDA-ubiquitin-dependent protein catabolic process15448698
GO:0007165TAS-signal transduction9990853
GO:0016032IEA-viral process-
GO:0016055TAS-Wnt signaling pathway-
GO:0016567IDA-protein ubiquitination16885022
GO:0031146IBA-SCF-dependent proteasomal ubiquitin-dependent protein catabolic process-
GO:0031648IMP-protein destabilization16885022
GO:0033598IEA-mammary gland epithelial cell proliferation-
GO:0038061TAS-NIK/NF-kappaB signaling-
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0042752IDA-regulation of circadian rhythm15917222
GO:0042753ISS-positive regulation of circadian rhythm-
GO:0043122IEA-regulation of I-kappaB kinase/NF-kappaB signaling-
GO:0043161IDA-proteasome-mediated ubiquitin-dependent protein catabolic process15917222
GO:0043161TAS-proteasome-mediated ubiquitin-dependent protein catabolic process-
GO:0043433TAS-negative regulation of sequence-specific DNA binding transcription factor activity11001584
GO:0043687TAS-post-translational protein modification-
GO:0045862IMP-positive regulation of proteolysis16885022
GO:0045879TAS-negative regulation of smoothened signaling pathway11001584
GO:0045892IMP-negative regulation of transcription, DNA-templated19966869
GO:0045893ISS-positive regulation of transcription, DNA-templated-
GO:0048511IEA-rhythmic process-
GO:0050852TAS-T cell receptor signaling pathway-
GO:0051403TAS-stress-activated MAPK cascade-
GO:0051437TAS-positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition-
GO:0060444IEA-branching involved in mammary gland duct morphogenesis-
GO:0060828IC-regulation of canonical Wnt signaling pathway12820959
GO:0061136IEA-regulation of proteasomal protein catabolic process-
GO:0071407IEA-cellular response to organic cyclic compound-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
BTRCAPC11445719615732 Affinity Capture-MS
BTRCAPC10682119615732 Affinity Capture-MS
BTRCATF410695816219772 Affinity Capture-Western
BTRCATF411445716219772 Affinity Capture-Western
BTRCCD41073589660940 Affinity Capture-Western
BTRCCD41144579660940 Affinity Capture-Western
BTRCCDC25A11445714681206 15798217 19615732 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BTRCCDC25A10742814681206 15798217 19615732 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BTRCCDC3411445710531035 12037680 19615732 Affinity Capture-MS; Biochemical Activity; Reconstituted Complex
BTRCCDC3410743210531035 12037680 19615732 Affinity Capture-MS; Biochemical Activity; Reconstituted Complex
BTRCCTNNB111445714516475 16798748 Affinity Capture-Western
BTRCCTNNB110788014516475 16798748 Affinity Capture-Western
BTRCDLG110808312902344 Affinity Capture-Western; Reconstituted Complex
BTRCDLG111445712902344 Affinity Capture-Western; Reconstituted Complex
BTRCEP30011445719297328 Affinity Capture-Western
BTRCEP30010834719297328 Affinity Capture-Western
BTRCEPOR11445717327410 Affinity Capture-Western
BTRCEPOR10837117327410 Affinity Capture-Western
BTRCGH111445717500058 Reconstituted Complex
BTRCGH110895517500058 Reconstituted Complex
BTRCGHR11445717500058 Reconstituted Complex
BTRCGHR10895717500058 Reconstituted Complex
BTRCGLI311445716705181 Affinity Capture-Western
BTRCGLI310899916705181 Affinity Capture-Western
BTRCHIVEP111445719615732 Affinity Capture-MS
BTRCHIVEP110934319615732 Affinity Capture-MS
BTRCHIVEP211445719615732 Affinity Capture-MS
BTRCHIVEP210934419615732 Affinity Capture-MS
BTRCIGHM11445719615732 Affinity Capture-MS
BTRCIGHM10972719615732 Affinity Capture-MS
BTRCIKBKB10976711158290 Affinity Capture-Western
BTRCIKBKB11445711158290 Affinity Capture-Western
BTRCJUP11445710803460 Affinity Capture-Western
BTRCJUP10993110803460 Affinity Capture-Western
BTRCSMAD311445714988407 Affinity Capture-Western
BTRCSMAD311026314988407 Affinity Capture-Western
BTRCSMAD411445714988407 15314162 15855639 16865698 Affinity Capture-Western; Two-hybrid
BTRCSMAD411026414988407 15314162 15855639 16865698 Affinity Capture-Western; Two-hybrid
BTRCNFKB111085711158290 12482991 Affinity Capture-Western; Reconstituted Complex
BTRCNFKB111445711158290 12482991 Affinity Capture-Western; Reconstituted Complex
BTRCNFKB211445711994270 15140882 16303288 18617892 Affinity Capture-Western; Protein-peptide
BTRCNFKB211085811994270 15140882 16303288 18617892 Affinity Capture-Western; Protein-peptide
BTRCNFKBIA1144579990853 10644755 Affinity Capture-Western; Reconstituted Complex
BTRCNFKBIA1108599990853 10644755 Affinity Capture-Western; Reconstituted Complex
BTRCNFKBIB11445710514424 Affinity Capture-Western
BTRCNFKBIB11086010514424 Affinity Capture-Western
BTRCNRD111095419615732 Affinity Capture-MS
BTRCNRD111445719615732 Affinity Capture-MS
BTRCPER111121015917222 Affinity Capture-Western; Reconstituted Complex
BTRCPER111445715917222 Affinity Capture-Western; Reconstituted Complex
BTRCPRKACA11155319615732 Affinity Capture-MS
BTRCPRKACA11445719615732 Affinity Capture-MS
BTRCRELA1144579990853 Affinity Capture-Western
BTRCRELA1119029990853 Affinity Capture-Western
BTRCSERPINB411222419615732 Affinity Capture-MS
BTRCSERPINB411445719615732 Affinity Capture-MS
BTRCSKP11144579660940 10531035 10644755 10918611 11483504 12609982 12820959 15070733 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
BTRCSKP11123919660940 10531035 10644755 10918611 11483504 12609982 12820959 15070733 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
BTRCSNAI111445715448698 15647282 Affinity Capture-Western
BTRCSNAI111249915448698 15647282 Affinity Capture-Western
BTRCSNRNP7011250911850407 Affinity Capture-Western
BTRCSNRNP7011445711850407 Affinity Capture-Western
BTRCTNF11445715485837 Affinity Capture-MS
BTRCTNF11297915485837 Affinity Capture-MS
BTRCUBA111316517965458 Reconstituted Complex
BTRCUBA111445717965458 Reconstituted Complex
BTRCUBE2D211445710531035 Biochemical Activity
BTRCUBE2D211317010531035 Biochemical Activity
BTRCUBE2D311317117965458 Reconstituted Complex
BTRCUBE2D311445717965458 Reconstituted Complex
BTRCWEE111330315070733 Affinity Capture-Western
BTRCWEE111445715070733 Affinity Capture-Western
BTRCCUL111403210531035 10644755 11483504 11850407 12609982 15966899 19615732 Affinity Capture-MS; Affinity Capture-Western
BTRCCUL111445710531035 10644755 11483504 11850407 12609982 15966899 19615732 Affinity Capture-MS; Affinity Capture-Western
BTRCOGT11445719615732 Affinity Capture-MS
BTRCOGT11404919615732 Affinity Capture-MS
BTRCTP6311445717965458 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BTRCTP6311418117965458 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
FBXW11BTRC11688710644755 19615732 Affinity Capture-MS; Affinity Capture-Western
FBXW11BTRC11445710644755 19615732 Affinity Capture-MS; Affinity Capture-Western
BTRCBTRC11445710644755 Affinity Capture-Western
UBE2R2BTRC12026612037680 Reconstituted Complex
UBE2R2BTRC11445712037680 Reconstituted Complex
TBK1BTRC11445714743216 Affinity Capture-MS
TBK1BTRC11887814743216 Affinity Capture-MS
FBXO5BTRC11765515469984 Reconstituted Complex
FBXO5BTRC11445715469984 Reconstituted Complex
TRIM9BTRC11445716189514 Two-hybrid
TRIM9BTRC12528016189514 Two-hybrid
CLSPNBTRC12201516885021 16885022 Affinity Capture-Western
CLSPNBTRC11445716885021 16885022 Affinity Capture-Western
FAM123BBTRC12655617510365 Reconstituted Complex
FAM123BBTRC11445717510365 Reconstituted Complex
PDCD4BTRC11809818296647 Affinity Capture-Western
PDCD4BTRC11445718296647 Affinity Capture-Western
C13orf34BTRC12295418378770 19615732 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
C13orf34BTRC11445718378770 19615732 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
PTTG1BTRC11466318460583 Affinity Capture-Western
PTTG1BTRC11445718460583 Affinity Capture-Western
HIPK2BTRC11881518765672 Affinity Capture-Western
HIPK2BTRC11445718765672 Affinity Capture-Western
TUBGCP3BTRC11445719615732 Affinity Capture-MS
TUBGCP3BTRC11569519615732 Affinity Capture-MS
NUDCBTRC11595019615732 Affinity Capture-MS
NUDCBTRC11445719615732 Affinity Capture-MS
TUBGCP2BTRC11445719615732 Affinity Capture-MS
TUBGCP2BTRC11605519615732 Affinity Capture-MS
CLPXBTRC11445719615732 Affinity Capture-MS
CLPXBTRC11605619615732 Affinity Capture-MS
GPRASP2BTRC12539919615732 Affinity Capture-MS
GPRASP2BTRC11445719615732 Affinity Capture-MS
SUN2BTRC11731219615732 Affinity Capture-MS
SUN2BTRC11445719615732 Affinity Capture-MS
KRT79BTRC13079619615732 Affinity Capture-MS
KRT79BTRC11445719615732 Affinity Capture-MS
COPS4BTRC11932419615732 Affinity Capture-MS
COPS4BTRC11445719615732 Affinity Capture-MS
USP47BTRC11445719615732 Affinity Capture-MS
USP47BTRC12036019615732 Affinity Capture-MS
KEAP1BTRC11445719615732 Affinity Capture-MS
KEAP1BTRC11515619615732 Affinity Capture-MS
PHLPP1BTRC11684319797085 Affinity Capture-Western
PHLPP1BTRC11445719797085 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1338871
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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