AutismKB 2.0

Annotation Details for TNFSF18


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Basic Information Top
Gene Symbol:TNFSF18 ( AITRL,GITRL,MGC138237,TL6,hGITRL )
Gene Full Name: tumor necrosis factor (ligand) superfamily, member 18
Band: 1q25.1
Quick LinksEntrez ID:8995; OMIM: 603898; Uniprot ID:TNF18_HUMAN; ENSEMBL ID: ENSG00000120337; HGNC ID: 11932
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005615IEA-extracellular space-
GO:0005886TAS-plasma membrane-
GO:0009986IBA-cell surface-
GO:0009986ISS-cell surface-
GO:0016021IEA-integral component of membrane-
GO ID Evidence Qualifier GO_term References
GO:0005102TAS-receptor binding10074428
GO:0005125IEA-cytokine activity-
GO:0032813IBA-tumor necrosis factor receptor superfamily binding-
GO:0032813ISS-tumor necrosis factor receptor superfamily binding-
GO ID Evidence Qualifier GO_term References
GO:0002250IEA-adaptive immune response-
GO:0002309IBA-T cell proliferation involved in immune response-
GO:0002309ISS-T cell proliferation involved in immune response-
GO:0002687IMP-positive regulation of leukocyte migration23892569
GO:0007165TAS-signal transduction10074428
GO:0007267TAS-cell-cell signaling10074428
GO:0010759IEA-positive regulation of macrophage chemotaxis-
GO:0033209IBA-tumor necrosis factor-mediated signaling pathway-
GO:0033209ISS-tumor necrosis factor-mediated signaling pathway-
GO:0033209TAS-tumor necrosis factor-mediated signaling pathway-
GO:0042129IBA-regulation of T cell proliferation-
GO:0042129ISS-regulation of T cell proliferation-
GO:0042531IMP-positive regulation of tyrosine phosphorylation of STAT protein23892569
GO:0043066TAS-negative regulation of apoptotic process10074428
GO:0045785IMP-positive regulation of cell adhesion23892569
GO:0050729IEA-positive regulation of inflammatory response-
GO:0051092ISS-positive regulation of NF-kappaB transcription factor activity-
GO:0090026IEA-positive regulation of monocyte chemotaxis-
GO:0090073IEA-positive regulation of protein homodimerization activity-
GO:2000329IEA-negative regulation of T-helper 17 cell lineage commitment-
GO:2000508IEA-regulation of dendritic cell chemotaxis-
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2673064
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-101109-1'