AutismKB 2.0

Annotation Details for NOL3


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Basic Information Top
Gene Symbol:NOL3 ( ARC,FLJ35304,MYP,NOP,NOP30 )
Gene Full Name: nucleolar protein 3 (apoptosis repressor with CARD domain)
Band: 16q22.1
Quick LinksEntrez ID:8996; OMIM: 605235; Uniprot ID:NOL3_HUMAN; ENSEMBL ID: ENSG00000140939; HGNC ID: 7869
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005730IEA-nucleolus-
GO:0005739ISS-mitochondrion-
GO:0005829TAS-cytosol10196175
GO:0016020IEA-membrane-
GO:0016529IEA-sarcoplasmic reticulum-
GO ID Evidence Qualifier GO_term References
GO:0003723TAS-RNA binding10196175
GO:0005123IEA-death receptor binding-
GO:0005509IMP-calcium ion binding15509781
GO:0005515IPI-protein binding10196175
GO:0035877IEA-death effector domain binding-
GO:0042802IPI-identical protein binding16189514
GO:0043027IDA-cysteine-type endopeptidase inhibitor activity involved in apoptotic process9560245
GO:0089720IPI-caspase binding9560245
GO ID Evidence Qualifier GO_term References
GO:0001666IEA-response to hypoxia-
GO:0001974IEA-blood vessel remodeling-
GO:0002931IEA-response to ischemia-
GO:0006376IDA-mRNA splice site selection10196175
GO:0008380TAS-RNA splicing10196175
GO:0010659IEA-cardiac muscle cell apoptotic process-
GO:0010667IEA-negative regulation of cardiac muscle cell apoptotic process-
GO:0010804IEA-negative regulation of tumor necrosis factor-mediated signaling pathway-
GO:0014736IEA-negative regulation of muscle atrophy-
GO:0014808IDA-release of sequestered calcium ion into cytosol by sarcoplasmic reticulum15509781
GO:0014876IEA-response to injury involved in regulation of muscle adaptation-
GO:0042345IEA-regulation of NF-kappaB import into nucleus-
GO:0043066IMP-negative regulation of apoptotic process15509781
GO:0051259IDA-protein oligomerization10196175
GO:0060547IEA-negative regulation of necrotic cell death-
GO:0090201IDA-negative regulation of release of cytochrome c from mitochondria15004034
GO:0097193IEA-intrinsic apoptotic signaling pathway-
GO:1902109IEA-negative regulation of mitochondrial membrane permeability involved in apoptotic process-
GO:1902176IDA-negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway15004034
GO:1990001IDA-inhibition of cysteine-type endopeptidase activity involved in apoptotic process15509781
GO:2001237IDA-negative regulation of extrinsic apoptotic signaling pathway9560245
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NOL3FAS1068519560245 Phenotypic Suppression
NOL3FAS1144779560245 Phenotypic Suppression
NOL3CASP21072859560245 Affinity Capture-Western
NOL3CASP21144779560245 Affinity Capture-Western
NOL3CASP81072919560245 Affinity Capture-Western; Phenotypic Suppression
NOL3CASP81144779560245 Affinity Capture-Western; Phenotypic Suppression
NOL3TNFRSF1A1129869560245 Phenotypic Suppression
NOL3TNFRSF1A1144779560245 Phenotypic Suppression
NOL3VASP11325116189514 Two-hybrid
NOL3VASP11447716189514 Two-hybrid
NOL3SRSF911423110196175 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NOL3SRSF911447710196175 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NOL3TRADD1142579560245 Phenotypic Suppression
NOL3TRADD1144779560245 Phenotypic Suppression
NOL3TNFRSF251142589560245 Phenotypic Suppression
NOL3TNFRSF251144779560245 Phenotypic Suppression
NOL3FADD1143029560245 Phenotypic Suppression
NOL3FADD1144779560245 Phenotypic Suppression
NOL3CFLAR1143649560245 Phenotypic Suppression
NOL3CFLAR1144779560245 Phenotypic Suppression
NOL3NOL311447716189514 Affinity Capture-Western; Two-hybrid
SIRPANOL311447716189514 Two-hybrid
SIRPANOL312675216189514 Two-hybrid
ETNK2NOL311447716189514 Two-hybrid
ETNK2NOL312051916189514 Two-hybrid
NIF3L1NOL311447716189514 Two-hybrid
NIF3L1NOL312192216189514 Two-hybrid
PNKPNOL311447717353931 Affinity Capture-MS
PNKPNOL311644017353931 Affinity Capture-MS
PACSIN3NOL311447717353931 Affinity Capture-MS
PACSIN3NOL311889617353931 Affinity Capture-MS
Gene Symbol Interactant Interaction ID References Description
NOL3FAS18244715383280 ARC interacts with an unspecified isoform of Fas.
NOL3CASP818245115383280 ARC interacts with procaspase-8.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1925938
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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