AutismKB 2.0

Annotation Details for KALRN


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Basic Information Top
Gene Symbol:KALRN ( ARHGEF24,DUET,DUO,FLJ12332,FLJ16443,FLJ18196,FLJ18623,HAPIP,TRAD )
Gene Full Name: kalirin, RhoGEF kinase
Band: 3q21.1-q21.2
Quick LinksEntrez ID:8997; OMIM: 604605; Uniprot ID:KALRN_HUMAN; ENSEMBL ID: ENSG00000160145; HGNC ID: 4814
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654IDA-nucleoplasm-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0014069IEA-postsynaptic density-
GO:0015629TAS-actin cytoskeleton10023074
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0004674IEA-protein serine/threonine kinase activity-
GO:0005085EXP-guanyl-nucleotide exchange factor activity12546821
GO:0005085TAS-guanyl-nucleotide exchange factor activity-
GO:0005089TAS-Rho guanyl-nucleotide exchange factor activity-
GO:0005096TAS-GTPase activator activity-
GO:0005524IEA-ATP binding-
GO:0030676IEA-Rac guanyl-nucleotide exchange factor activity-
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0001662IEA-behavioral fear response-
GO:0006468IEA-protein phosphorylation-
GO:0007165TAS-signal transduction9285789
GO:0007266IEA-Rho protein signal transduction-
GO:0007399ISS-nervous system development-
GO:0007528IEA-neuromuscular junction development-
GO:0007595IEA-lactation-
GO:0007613IEA-memory-
GO:0008344IEA-adult locomotory behavior-
GO:0009612IEA-response to mechanical stimulus-
GO:0014909IEA-smooth muscle cell migration-
GO:0016192TAS-vesicle-mediated transport9285789
GO:0035023IEA-regulation of Rho protein signal transduction-
GO:0035176IEA-social behavior-
GO:0035556ISS-intracellular signal transduction-
GO:0042711IEA-maternal behavior-
GO:0043065TAS-positive regulation of apoptotic process-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0046959IEA-habituation-
GO:0048013TAS-ephrin receptor signaling pathway-
GO:0048148IEA-behavioral response to cocaine-
GO:0048168IEA-regulation of neuronal synaptic plasticity-
GO:0048659IEA-smooth muscle cell proliferation-
GO:0051056TAS-regulation of small GTPase mediated signal transduction-
GO:0051966IEA-regulation of synaptic transmission, glutamatergic-
GO:0060125IEA-negative regulation of growth hormone secretion-
GO:0060137IEA-maternal process involved in parturition-
GO:0061003IEA-positive regulation of dendritic spine morphogenesis-
GO:0061368IEA-behavioral response to formalin induced pain-
GO:1900273IEA-positive regulation of long-term synaptic potentiation-
GO:1903076IEA-regulation of protein localization to plasma membrane-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
KALRNPAM1144789139723 Two-hybrid
KALRNPAM1111019139723 Two-hybrid
KALRNRAC11144789139723 Reconstituted Complex
KALRNRAC11118179139723 Reconstituted Complex
KALRNSUMO311447816620772 Affinity Capture-MS
KALRNSUMO311249616620772 Affinity Capture-MS
KALRNSUMO211447816620772 Affinity Capture-MS
KALRNSUMO211249716620772 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2685385
  • Data Attributes: HomoloGene calculated
No data