AutismKB 2.0

Annotation Details for SOCS3


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Basic Information Top
Gene Symbol:SOCS3 ( ATOD4,CIS3,Cish3,MGC71791,SOCS-3,SSI-3,SSI3 )
Gene Full Name: suppressor of cytokine signaling 3
Band: 17q25.3
Quick LinksEntrez ID:9021; OMIM: 604176; Uniprot ID:SOCS3_HUMAN; ENSEMBL ID: ENSG00000184557; HGNC ID: 19391
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IBA-cytoplasm-
GO:0005829TAS-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0001784IEA-phosphotyrosine residue binding-
GO:0004860TAS-protein kinase inhibitor activity9266833
GO:0005515IPI-protein binding19027008
GO ID Evidence Qualifier GO_term References
GO:0006469IEA-negative regulation of protein kinase activity-
GO:0007259IEA-JAK-STAT cascade-
GO:0016567IEA-protein ubiquitination-
GO:0019221IBA-cytokine-mediated signaling pathway-
GO:0040008IEA-regulation of growth-
GO:0042532IMP-negative regulation of tyrosine phosphorylation of STAT protein25019494
GO:0043066IEA-negative regulation of apoptotic process-
GO:0043687TAS-post-translational protein modification-
GO:0045597IEA-positive regulation of cell differentiation-
GO:0046426IMP-negative regulation of JAK-STAT cascade25019494
GO:0046627IBA-negative regulation of insulin receptor signaling pathway-
GO:0050728IEA-negative regulation of inflammatory response-
GO:0060334TAS-regulation of interferon-gamma-mediated signaling pathway-
GO:0060670IEA-branching involved in labyrinthine layer morphogenesis-
GO:0060674IEA-placenta blood vessel development-
GO:0060707IEA-trophoblast giant cell differentiation-
GO:0060708IEA-spongiotrophoblast differentiation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SOCS3CSF1R10782312133942 Affinity Capture-Western
SOCS3CSF1R11448812133942 Affinity Capture-Western
SOCS3EGFR10827612070153 Affinity Capture-Western
SOCS3EGFR11448812070153 Affinity Capture-Western
SOCS3EPOR11448810882725 12027890 Affinity Capture-Western; Reconstituted Complex
SOCS3EPOR10837110882725 12027890 Affinity Capture-Western; Reconstituted Complex
SOCS3PTK2B1084809344848 Two-hybrid
SOCS3PTK2B1144889344848 Two-hybrid
SOCS3GHR10895710585430 Reconstituted Complex
SOCS3GHR11448810585430 Reconstituted Complex
SOCS3IGF1R10970111071852 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SOCS3IGF1R11448811071852 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SOCS3IL6ST10978612403768 Affinity Capture-Western; Reconstituted Complex
SOCS3IL6ST11448812403768 Affinity Capture-Western; Reconstituted Complex
SOCS3INSR11448812560330 Affinity Capture-Western
SOCS3INSR10985412560330 Affinity Capture-Western
SOCS3JAK21144889344848 10421843 10882725 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SOCS3JAK21099209344848 10421843 10882725 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SOCS3LEPR11448811018044 Reconstituted Complex
SOCS3LEPR11014411018044 Reconstituted Complex
SOCS3MAP3K511448816407264 Affinity Capture-Western
SOCS3MAP3K511038116407264 Affinity Capture-Western
SOCS3NONO11090418952062 Affinity Capture-Western
SOCS3NONO11448818952062 Affinity Capture-Western
SOCS3PIN111448816169070 Two-hybrid
SOCS3PIN111131716169070 Two-hybrid
SOCS3PRLR11160311713228 Affinity Capture-Western
SOCS3PRLR11448811713228 Affinity Capture-Western
SOCS3PTPN1111448812403768 Affinity Capture-Western; Reconstituted Complex
SOCS3PTPN1111174512403768 Affinity Capture-Western; Reconstituted Complex
SOCS3RASA111448811331873 Affinity Capture-Western; Reconstituted Complex
SOCS3RASA111185611331873 Affinity Capture-Western; Reconstituted Complex
SOCS3MAP3K711448816543409 Affinity Capture-Western
SOCS3MAP3K711274816543409 Affinity Capture-Western
SOCS3TRAF611448816543409 Affinity Capture-Western
SOCS3TRAF611304116543409 Affinity Capture-Western
SOCS3CXCR411448812163560 Affinity Capture-Western
SOCS3CXCR411360712163560 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1201791
  • Data Attributes: HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-7349'