AutismKB 2.0

Annotation Details for BRSK2


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Basic Information Top
Gene Symbol:BRSK2 ( C11orf7,FLJ41362,PEN11B,SAD1,STK29 )
Gene Full Name: BR serine/threonine kinase 2
Band: 11p15.5
Quick LinksEntrez ID:9024; OMIM: 609236; Uniprot ID:BRSK2_HUMAN; ENSEMBL ID: ENSG00000174672; HGNC ID: 11405
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IBA-nucleus-
GO:0005737IDA-cytoplasm22713462
GO:0005783IDA-endoplasmic reticulum23907667
GO:0005813IDA-centrosome23029325
GO:0048471IEA-perinuclear region of cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0000287IDA-magnesium ion binding14976552
GO:0004674IDA-protein serine/threonine kinase activity14976552
GO:0005524IDA-ATP binding14976552
GO:0019901IEA-protein kinase binding-
GO:0050321IDA-tau-protein kinase activity21985311
GO:0050321ISS-tau-protein kinase activity-
GO:0051117IDA-ATPase binding23907667
GO:0060590NAS-ATPase regulator activity23907667
GO ID Evidence Qualifier GO_term References
GO:0000086IMP-G2/M transition of mitotic cell cycle23029325
GO:0006468IDA-protein phosphorylation14976552
GO:0006887IEA-exocytosis-
GO:0007409ISS-axonogenesis-
GO:0018105IEA-peptidyl-serine phosphorylation-
GO:0030010ISS-establishment of cell polarity-
GO:0030182ISS-neuron differentiation-
GO:0031532IMP-actin cytoskeleton reorganization22669945
GO:0036503IMP-ERAD pathway23907667
GO:0043462NAS-regulation of ATPase activity23907667
GO:0051301IEA-cell division-
GO:0061178IMP-regulation of insulin secretion involved in cellular response to glucose stimulus22669945
GO:0061178ISS-regulation of insulin secretion involved in cellular response to glucose stimulus-
GO:0070059IMP-intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress22713462
GO:1904152IC-regulation of retrograde protein transport, ER to cytosol23907667
GO:1904152NAS-regulation of retrograde protein transport, ER to cytosol23907667
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
BRSK2UBC11449118254724 Reconstituted Complex
BRSK2UBC11316418254724 Reconstituted Complex
KBTBD7BRSK211449120562859 Affinity Capture-MS
KBTBD7BRSK212387320562859 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1923020
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-100422-2'