AutismKB 2.0

Annotation Details for PIAS2


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Basic Information Top
Gene Symbol:PIAS2 ( MGC102682,MIZ1,PIASX,PIASX-ALPHA,PIASX-BETA,SIZ2,ZMIZ4,miz )
Gene Full Name: protein inhibitor of activated STAT, 2
Band: 18q21.1
Quick LinksEntrez ID:9063; OMIM: 603567; Uniprot ID:PIAS2_HUMAN; ENSEMBL ID: ENSG00000078043; HGNC ID: 17311
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus11477070
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0016605IDAcolocalizes_withPML body22406621
GO:0016607IEA-nuclear speck-
GO ID Evidence Qualifier GO_term References
GO:0003677IEA-DNA binding-
GO:0003713NAS-transcription coactivator activity15572661
GO:0005515IPI-protein binding11477070
GO:0008134IPI-transcription factor binding20408817
GO:0008270IEA-zinc ion binding-
GO:0016874IEA-ligase activity-
GO:0019789EXP-SUMO transferase activity17283066
GO:0031625IEA-ubiquitin protein ligase binding-
GO:0050681NAS-androgen receptor binding15572661
GO:0061665IDA-SUMO ligase activity18579533
GO ID Evidence Qualifier GO_term References
GO:0006351IEA-transcription, DNA-templated-
GO:0016925IDA-protein sumoylation22406621
GO:0016925IEA-protein sumoylation-
GO:0030521NAS-androgen receptor signaling pathway15572661
GO:0045667IEA-regulation of osteoblast differentiation-
GO:0045893NAS-positive regulation of transcription, DNA-templated15572661
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0060766IDA-negative regulation of androgen receptor signaling pathway11477070
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PIAS2AKT111452317533377 Two-hybrid
PIAS2AKT110671017533377 Two-hybrid
PIAS2AR1068629920921 11117529 Reconstituted Complex; Two-hybrid
PIAS2AR1145239920921 11117529 Reconstituted Complex; Two-hybrid
PIAS2CDKN2A11452319901969 Affinity Capture-Western; Two-hybrid
PIAS2CDKN2A10746319901969 Affinity Capture-Western; Two-hybrid
PIAS2DNMT3A11452314752048 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PIAS2DNMT3A10812514752048 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PIAS2ESR111452311117529 Reconstituted Complex
PIAS2ESR110840311117529 Reconstituted Complex
PIAS2ESR211452311117529 Reconstituted Complex
PIAS2ESR210840411117529 Reconstituted Complex
PIAS2GLUL11452320936779 Two-hybrid
PIAS2GLUL10901420936779 Two-hybrid
PIAS2NR3C110916511117529 Reconstituted Complex
PIAS2NR3C111452311117529 Reconstituted Complex
PIAS2ITGB511452312356872 Two-hybrid
PIAS2ITGB510989912356872 Two-hybrid
PIAS2JUN10992811867732 Reconstituted Complex
PIAS2JUN11452311867732 Reconstituted Complex
PIAS2MBD111032217066076 Reconstituted Complex; Two-hybrid
PIAS2MBD111452317066076 Reconstituted Complex; Two-hybrid
PIAS2MITF11452316029420 Reconstituted Complex
PIAS2MITF11043216029420 Reconstituted Complex
PIAS2MYC11069411283613 17418410 17471507 18923429 Affinity Capture-Western
PIAS2MYC11452311283613 17418410 17471507 18923429 Affinity Capture-Western
PIAS2PGR11126011117529 Reconstituted Complex
PIAS2PGR11452311117529 Reconstituted Complex
PIAS2TRIM2711191915907835 Affinity Capture-Western; Two-hybrid
PIAS2TRIM2711452315907835 Affinity Capture-Western; Two-hybrid
PIAS2SIAH111237217533377 Two-hybrid
PIAS2SIAH111452317533377 Two-hybrid
PIAS2SIAH211452317533377 Two-hybrid
PIAS2SIAH211237317533377 Two-hybrid
PIAS2SUMO211452319394292 Affinity Capture-MS
PIAS2SUMO211249719394292 Affinity Capture-MS
PIAS2SREBF211452320936779 Two-hybrid
PIAS2SREBF211259920936779 Two-hybrid
PIAS2STAT411452312716907 Affinity Capture-Western
PIAS2STAT411265212716907 Affinity Capture-Western
PIAS2TP5311301011867732 19901969 Affinity Capture-Western; Reconstituted Complex
PIAS2TP5311452311867732 19901969 Affinity Capture-Western; Reconstituted Complex
PIAS2UBE2I11317711867732 14609633 16189514 20936779 Reconstituted Complex; Two-hybrid
PIAS2UBE2I11452311867732 14609633 16189514 20936779 Reconstituted Complex; Two-hybrid
PIAS2SUMO111318811867732 14609633 Reconstituted Complex; Two-hybrid
PIAS2SUMO111452311867732 14609633 Reconstituted Complex; Two-hybrid
PARK7PIAS211452311477070 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PARK7PIAS211644611477070 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GTF2IRD1PIAS211452312193603 Reconstituted Complex
GTF2IRD1PIAS211493912193603 Reconstituted Complex
NAV2PIAS211452316189514 Two-hybrid
NAV2PIAS212460616189514 Two-hybrid
HUWE1PIAS211452316269333 Affinity Capture-Western; Reconstituted Complex
HUWE1PIAS211538516269333 Affinity Capture-Western; Reconstituted Complex
ZBTB4PIAS212169318451802 Affinity Capture-Western
ZBTB4PIAS211452318451802 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
CDV3PIAS218384215580267 Miz1 interacts with p-H41 transcription start site.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1096566
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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