AutismKB 2.0

Annotation Details for MAP3K6


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Basic Information Top
Gene Symbol:MAP3K6 ( ASK2,MAPKKK6,MEKK6,MGC125653,MGC20114 )
Gene Full Name: mitogen-activated protein kinase kinase kinase 6
Band: 1p36.11
Quick LinksEntrez ID:9064; OMIM: 604468; Uniprot ID:M3K6_HUMAN; ENSEMBL ID: ENSG00000142733; HGNC ID: 6858
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005622IEA-intracellular-
GO ID Evidence Qualifier GO_term References
GO:0000287IDA-magnesium ion binding9875215
GO:0004709IDA-MAP kinase kinase kinase activity9875215
GO:0005524IDA-ATP binding9875215
GO ID Evidence Qualifier GO_term References
GO:0000186IEA-activation of MAPKK activity-
GO:0006468IDA-protein phosphorylation9875215
GO:0007165TAS-signal transduction9875215
GO:0007257TAS-activation of JUN kinase activity9875215
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MAP3K6MAP3K51145249875215 11689443 Affinity Capture-Western; Two-hybrid
MAP3K6MAP3K51103819875215 11689443 Affinity Capture-Western; Two-hybrid
MAP3K6PRKAA211452420562859 Affinity Capture-MS
MAP3K6PRKAA211155020562859 Affinity Capture-MS
MAP3K6PRKAB211155220562859 Affinity Capture-MS
MAP3K6PRKAB211452420562859 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1855691
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018