AutismKB 2.0

Annotation Details for ASH2L


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Basic Information Top
Gene Symbol:ASH2L ( ASH2,ASH2L1,ASH2L2,Bre2 )
Gene Full Name: ash2 (absent, small, or homeotic)-like (Drosophila)
Band: 8p11.23
Quick LinksEntrez ID:9070; OMIM: 604782; Uniprot ID:ASH2L_HUMAN; ENSEMBL ID: ENSG00000129691; HGNC ID: 744
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus15199122
GO:0005634IMP-nucleus22723415
GO:0005654TAS-nucleoplasm-
GO:0005719IEA-nuclear euchromatin-
GO:0035097IDA-histone methyltransferase complex17355966
GO:0035097IPI-histone methyltransferase complex14992727
GO:0044666IDA-MLL3/4 complex17500065
GO:0048188IDA-Set1C/COMPASS complex17998332
GO:0071339IEA-MLL1 complex-
GO ID Evidence Qualifier GO_term References
GO:0003677IC-DNA binding10393421
GO:0005515IPI-protein binding12482968
GO:0008013IDA-beta-catenin binding22723415
GO:0018024TAS-histone-lysine N-methyltransferase activity-
GO:0042800IDAcontributes_tohistone methyltransferase activity (H3-K4 specific)17355966
GO:0044212IDA-transcription regulatory region DNA binding16603732
GO:0046872IEA-metal ion binding-
GO:1990188IEA-euchromatin binding-
GO ID Evidence Qualifier GO_term References
GO:0006351NAS-transcription, DNA-templated10393421
GO:0006355NAS-regulation of transcription, DNA-templated10393421
GO:0006366TAS-transcription from RNA polymerase II promoter10393421
GO:0006974IDA-cellular response to DNA damage stimulus17500065
GO:0008284IMP-positive regulation of cell proliferation18245475
GO:0030097NAS-hemopoiesis11466562
GO:0043627IDA-response to estrogen16603732
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0051568IDA-histone H3-K4 methylation17355966
GO:1904837TAS-beta-catenin-TCF complex assembly-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ASH2LCTNNB111452816510874 16510875 Reconstituted Complex
ASH2LCTNNB110788016510874 16510875 Reconstituted Complex
ASH2LHCFC111452815199122 Reconstituted Complex
ASH2LHCFC110930415199122 Reconstituted Complex
ASH2LMEF2D11037318026121 Affinity Capture-Western
ASH2LMEF2D11452818026121 Affinity Capture-Western
ASH2LMEN111452815199122 17050672 Affinity Capture-Western; Reconstituted Complex
ASH2LMEN111038415199122 17050672 Affinity Capture-Western; Reconstituted Complex
ASH2LMLL11044315199122 20064463 Affinity Capture-Western; Co-localization; Co-purification
ASH2LMLL11452815199122 20064463 Affinity Capture-Western; Co-localization; Co-purification
ASH2LMYB11452820093773 Affinity Capture-Western
ASH2LMYB11068720093773 Affinity Capture-Western
ASH2LPAX711111518066051 Affinity Capture-Western
ASH2LPAX711452818066051 Affinity Capture-Western
ASH2LRBBP511452815199122 15960974 16253997 17500065 17925232 19131338 Affinity Capture-Western; Reconstituted Complex
ASH2LRBBP511186415199122 15960974 16253997 17500065 17925232 19131338 Affinity Capture-Western; Reconstituted Complex
ASH2LUSF111452817846119 Affinity Capture-MS
ASH2LUSF111323717846119 Affinity Capture-MS
ASH2LKDM6A11452817761849 Affinity Capture-MS
ASH2LKDM6A11324617761849 Affinity Capture-MS
ASH2LMLL211375817925232 Affinity Capture-Western
ASH2LMLL211452817925232 Affinity Capture-Western
ASH2LHIST3H311389512482968 Reconstituted Complex
ASH2LHIST3H311452812482968 Reconstituted Complex
ASH2LHIST1H3A11394616713563 Biochemical Activity
ASH2LHIST1H3A11452816713563 Biochemical Activity
MLL3ASH2L11452812482968 17500065 Affinity Capture-Western; Reconstituted Complex
MLL3ASH2L12183512482968 17500065 Affinity Capture-Western; Reconstituted Complex
WDR5ASH2L11627215199122 15960974 16253997 17925232 18066051 Affinity Capture-Western; Reconstituted Complex
WDR5ASH2L11452815199122 15960974 16253997 17925232 18066051 Affinity Capture-Western; Reconstituted Complex
ASH2LASH2L11452815199122 17500065 Affinity Capture-Western; Reconstituted Complex
HCFC2ASH2L11895915199122 Reconstituted Complex
HCFC2ASH2L11452815199122 Reconstituted Complex
SRRM1ASH2L11554416159877 Affinity Capture-MS
SRRM1ASH2L11452816159877 Affinity Capture-MS
UNC119ASH2L11454816169070 Two-hybrid
UNC119ASH2L11452816169070 Two-hybrid
DPY30ASH2L12418116189514 Two-hybrid
DPY30ASH2L11452816189514 Two-hybrid
CXXC1ASH2L11904516253997 18082152 18680430 19433449 Affinity Capture-MS; Affinity Capture-Western
CXXC1ASH2L11452816253997 18082152 18680430 19433449 Affinity Capture-MS; Affinity Capture-Western
WDR82P1ASH2L11452816253997 Affinity Capture-Western
WDR82P1ASH2L60892916253997 Affinity Capture-Western
SETD1AASH2L11508816253997 17998332 Affinity Capture-Western
SETD1AASH2L11452816253997 17998332 Affinity Capture-Western
NCOA6ASH2L11452817500065 17925232 19047629 Affinity Capture-MS; Affinity Capture-Western
NCOA6ASH2L11669117500065 17925232 19047629 Affinity Capture-MS; Affinity Capture-Western
PAXIP1ASH2L11452817500065 17925232 Affinity Capture-MS; Affinity Capture-Western; Co-purification
PAXIP1ASH2L11662517500065 17925232 Affinity Capture-MS; Affinity Capture-Western; Co-purification
C16orf53ASH2L11452817500065 Affinity Capture-Western
C16orf53ASH2L12267217500065 Affinity Capture-Western
MLL4ASH2L11452817500065 Affinity Capture-Western
MLL4ASH2L11510417500065 Affinity Capture-Western
SETD1BASH2L11670217998332 Affinity Capture-Western
SETD1BASH2L11452817998332 Affinity Capture-Western
C11orf30ASH2L12127019131338 Affinity Capture-Western
C11orf30ASH2L11452819131338 Affinity Capture-Western
KIAA1967ASH2L11452819131338 Affinity Capture-Western
KIAA1967ASH2L12177519131338 Affinity Capture-Western
ZNF335ASH2L11452819131338 Affinity Capture-Western
ZNF335ASH2L12199419131338 Affinity Capture-Western
CHD8ASH2L12170920085832 Co-localization; Reconstituted Complex
CHD8ASH2L11452820085832 Co-localization; Reconstituted Complex
PHF8ASH2L11675120208542 Affinity Capture-Western
PHF8ASH2L11452820208542 Affinity Capture-Western
ZSCAN1ASH2L11452820211142 Two-hybrid
ZSCAN1ASH2L12982520211142 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1344416
  • Data Attributes: MGI curated and HomoloGene calculated
No data