AutismKB 2.0

Annotation Details for USP8


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Basic Information Top
Gene Symbol:USP8 ( FLJ34456,HumORF8,KIAA0055,MGC129718,UBPY )
Gene Full Name: ubiquitin specific peptidase 8
Band: 15q21.2
Quick LinksEntrez ID:9101; OMIM: 603158; Uniprot ID:UBP8_HUMAN; ENSEMBL ID: ENSG00000138592; HGNC ID: 12631
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IEA-nucleus-
GO:0005737IDA-cytoplasm18388320
GO:0005769IDA-early endosome16520378
GO:0005829IDA-cytosol16520378
GO:0005829TAS-cytosol-
GO:0014069IEA-postsynaptic density-
GO:0019897IDA-extrinsic component of plasma membrane16520378
GO:0030496IDA-midbody18388320
GO:0031313IBA-extrinsic component of endosome membrane-
GO:0043197IEA-dendritic spine-
GO ID Evidence Qualifier GO_term References
GO:0004197TAS-cysteine-type endopeptidase activity9827704
GO:0004843IDA-thiol-dependent ubiquitin-specific protease activity16520378
GO:0004843TAS-thiol-dependent ubiquitin-specific protease activity-
GO:0005515IPI-protein binding17711858
GO:0017124IEA-SH3 domain binding-
GO:0045296IDA-cadherin binding25468996
GO ID Evidence Qualifier GO_term References
GO:0000281IMP-mitotic cytokinesis18388320
GO:0006511IEA-ubiquitin-dependent protein catabolic process-
GO:0007032IMP-endosome organization16520378
GO:0008283TAS-cell proliferation9628861
GO:0016579IMP-protein deubiquitination18388320
GO:0016579TAS-protein deubiquitination-
GO:0070536IDA-protein K63-linked deubiquitination16520378
GO:0071108IDA-protein K48-linked deubiquitination16520378
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
USP8AKT111455517210635 Affinity Capture-Western
USP8AKT110671017210635 Affinity Capture-Western
USP8EGFR10827616120644 Affinity Capture-Western
USP8EGFR11455516120644 Affinity Capture-Western
USP8EPS1511455516771824 Affinity Capture-Western
USP8EPS1510837416771824 Affinity Capture-Western
USP8SFN11455515778465 Affinity Capture-MS
USP8SFN10907215778465 Affinity Capture-MS
USP8GRB211455510982817 Reconstituted Complex
USP8GRB210914210982817 Reconstituted Complex
USP8KRT3111455519615732 Affinity Capture-MS
USP8KRT3111007919615732 Affinity Capture-MS
USP8KRT8511455519615732 Affinity Capture-MS
USP8KRT8511008919615732 Affinity Capture-MS
USP8CHMP1A11114817711858 Reconstituted Complex
USP8CHMP1A11455517711858 Reconstituted Complex
USP8UBC11455516771824 Affinity Capture-Western
USP8UBC11316416771824 Affinity Capture-Western
USP8YWHAB11336117353931 Affinity Capture-MS
USP8YWHAB11455517353931 Affinity Capture-MS
USP8YWHAZ11455517353931 Affinity Capture-MS
USP8YWHAZ11336617353931 Affinity Capture-MS
USP8STAM11455510982817 17711858 Biochemical Activity; Reconstituted Complex
USP8STAM11372210982817 17711858 Biochemical Activity; Reconstituted Complex
USP8KRT3611423619615732 Affinity Capture-MS
USP8KRT3611455519615732 Affinity Capture-MS
STAM2USP811455510982817 13129930 Affinity Capture-Western; Protein-peptide; Reconstituted Complex
STAM2USP811554810982817 13129930 Affinity Capture-Western; Protein-peptide; Reconstituted Complex
OTUB1USP811455514661020 Affinity Capture-Western
OTUB1USP812075114661020 Affinity Capture-Western
RNF128USP811455514661020 Affinity Capture-Western
RNF128USP812273114661020 Affinity Capture-Western
RNF41USP811455515314180 Affinity Capture-MS; Affinity Capture-Western
RNF41USP811548815314180 Affinity Capture-MS; Affinity Capture-Western
YWHAQUSP811455517353931 Affinity Capture-MS
YWHAQUSP811616817353931 Affinity Capture-MS
CHMP1BUSP811455517711858 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CHMP1BUSP812139417711858 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CHMP7USP811455517711858 Reconstituted Complex
CHMP7USP812487917711858 Reconstituted Complex
CHMP4CUSP811455517711858 Reconstituted Complex
CHMP4CUSP812494617711858 Reconstituted Complex
BIRC6USP811455518329369 Affinity Capture-Western
BIRC6USP812152118329369 Affinity Capture-Western
KIF23USP811455518329369 Affinity Capture-Western
KIF23USP811487318329369 Affinity Capture-Western
USP22USP811455519615732 Affinity Capture-MS
USP22USP811691419615732 Affinity Capture-MS
RPL6P1USP811455519615732 Affinity Capture-MS
RPL6P1USP813671119615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1934029
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-1949'