Gene Symbol:	ARHGEF1 ( GEF1,LBCL2,LSC,P115-RHOGEF,SUB1.5 )
Gene Full Name:	Rho guanine nucleotide exchange factor (GEF) 1
Band:	19q13.2
Quick Links	Entrez ID:9138; OMIM: 601855; Uniprot ID:ARHG1_HUMAN; ENSEMBL ID: ENSG00000076928; HGNC ID: 681
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005737	TAS	-	cytoplasm	10747909
GO:0005829	IDA	-	cytosol	-
GO:0005829	TAS	-	cytosol	-
GO:0005886	IDA	-	plasma membrane	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0003723	IDA	-	RNA binding	22658674
GO:0005085	TAS	-	guanyl-nucleotide exchange factor activity	-
GO:0005089	TAS	-	Rho guanyl-nucleotide exchange factor activity	-
GO:0005096	IEA	-	GTPase activator activity	-
GO:0005515	IPI	-	protein binding	12681510

GO ID	Evidence	Qualifier	GO_term	References
GO:0007266	TAS	-	Rho protein signal transduction	10747909
GO:0008283	TAS	-	cell proliferation	8810315
GO:0035023	IEA	-	regulation of Rho protein signal transduction	-
GO:0043065	TAS	-	positive regulation of apoptotic process	-
GO:0043547	IEA	-	positive regulation of GTPase activity	-
GO:0050771	TAS	-	negative regulation of axonogenesis	-
GO:0051056	TAS	-	regulation of small GTPase mediated signal transduction	-

Gene Symbol	Interactant	Interaction ID	References	Description
ARHGEF1	RHOA	114585	12748184	Biochemical Activity
ARHGEF1	RHOA	106880	12748184	Biochemical Activity
ARHGEF1	ATR	114585	10608806	Protein-peptide
ARHGEF1	ATR	107027	10608806	Protein-peptide
ARHGEF1	CD44	114585	12748184	Affinity Capture-Western
ARHGEF1	CD44	107398	12748184	Affinity Capture-Western
ARHGEF1	GNA12	114585	14634662	Affinity Capture-Western; Reconstituted Complex
ARHGEF1	GNA12	109030	14634662	Affinity Capture-Western; Reconstituted Complex
ARHGEF1	HRAS	109501	12581858	Biochemical Activity
ARHGEF1	HRAS	114585	12581858	Biochemical Activity
ARHGEF1	PIK3CA	111308	12754211	Affinity Capture-Western
ARHGEF1	PIK3CA	114585	12754211	Affinity Capture-Western
ARHGEF1	RAP1A	114585	12581858	Biochemical Activity
ARHGEF1	RAP1A	111841	12581858	Biochemical Activity
ARHGEF1	SREBF2	112599	20936779	Two-hybrid
ARHGEF1	SREBF2	114585	20936779	Two-hybrid
ARHGEF1	TAF10	114585	17643375	Affinity Capture-MS
ARHGEF1	TAF10	112744	17643375	Affinity Capture-MS
GNA13	ARHGEF1	115914	9641916 12681510 14634662	Affinity Capture-Western; Reconstituted Complex
GNA13	ARHGEF1	114585	9641916 12681510 14634662	Affinity Capture-Western; Reconstituted Complex
ARHGEF1	ARHGEF1	114585	14712228	Affinity Capture-Western
MEPCE	ARHGEF1	114585	17643375	Affinity Capture-MS
MEPCE	ARHGEF1	121122	17643375	Affinity Capture-MS

Gene Symbol	Interactant	Interaction ID	References	Description
CNKSR1	ARHGEF1	217483	15753034	CNKSR1 (hCNK1) interacts with ARHGEF1 (p115RhoGEF). This interaction was modelled on a demonstrated interaction between human CNKSR1 and ARHGEF1 from an unspecified species.
GNA13	ARHGEF1	257798	15735747	GNA13 (alpha-13) interacts with ARHGEF1 (p115RhoGEF).

AutismKB 2.0

Annotation Details for ARHGEF1