AutismKB 2.0

Annotation Details for HGS


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Basic Information Top
Gene Symbol:HGS ( HRS,Vps27,ZFYVE8 )
Gene Full Name: hepatocyte growth factor-regulated tyrosine kinase substrate
Band: 17q25.3
Quick LinksEntrez ID:9146; OMIM: 604375; Uniprot ID:HGS_HUMAN; ENSEMBL ID: ENSG00000185359; HGNC ID: 4897
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005764IDA-lysosome-
GO:0005768IDA-endosome15611048
GO:0005769IDA-early endosome10861283
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0031901IEA-early endosome membrane-
GO:0032585IEA-multivesicular body membrane-
GO:0033565TAS-ESCRT-0 complex20588296
GO:0043231IDA-intracellular membrane-bounded organelle-
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding10861283
GO:0019904IPI-protein domain specific binding11984006
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0006622IMP-protein targeting to lysosome18767904
GO:0007165TAS-signal transduction9407053
GO:0008285TAS-negative regulation of cell proliferation9407053
GO:0010324IMP-membrane invagination18767904
GO:0010628IMP-positive regulation of gene expression18767904
GO:0016197NAS-endosomal transport10861283
GO:0016197TAS-endosomal transport-
GO:0016236TAS-macroautophagy20588296
GO:0016579TAS-protein deubiquitination-
GO:0036258TAS-multivesicular body assembly20588296
GO:0042059TAS-negative regulation of epidermal growth factor receptor signaling pathway-
GO:0042176TAS-regulation of protein catabolic process15611048
GO:0043405IMP-regulation of MAP kinase activity17714434
GO:0046426IDA-negative regulation of JAK-STAT cascade12444102
GO:0061024TAS-membrane organization-
GO:0072657IMP-protein localization to membrane18767904
GO:1903543IMP-positive regulation of exosomal secretion24105262
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HGSACLY10656319019082 Reconstituted Complex
HGSACLY11459319019082 Reconstituted Complex
HGSAPC10682120936779 Two-hybrid
HGSAPC11459320936779 Two-hybrid
HGSAPLP210683119019082 Reconstituted Complex
HGSAPLP211459319019082 Reconstituted Complex
HGSAPP10684819019082 Reconstituted Complex
HGSAPP11459319019082 Reconstituted Complex
HGSATP1A111459319019082 Reconstituted Complex
HGSATP1A110696619019082 Reconstituted Complex
HGSATP2A211459319019082 Reconstituted Complex
HGSATP2A210697819019082 Reconstituted Complex
HGSBSG10714719019082 Reconstituted Complex
HGSBSG11459319019082 Reconstituted Complex
HGSCBS10732119019082 Reconstituted Complex
HGSCBS11459319019082 Reconstituted Complex
HGSLYST10755211984006 Reconstituted Complex; Two-hybrid
HGSLYST11459311984006 Reconstituted Complex; Two-hybrid
HGSCLTC11459311532964 16716190 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HGSCLTC10762311532964 16716190 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HGSCRMP110779019019082 Reconstituted Complex
HGSCRMP111459319019082 Reconstituted Complex
HGSDECR110803019019082 Reconstituted Complex
HGSDECR111459319019082 Reconstituted Complex
HGSDLG411459312151521 Affinity Capture-Western; Two-hybrid
HGSDLG410808612151521 Affinity Capture-Western; Two-hybrid
HGSEGFR10827618508924 Affinity Capture-Western
HGSEGFR11459318508924 Affinity Capture-Western
HGSEPS1510837410809762 12551915 Co-fractionation; Reconstituted Complex; Two-hybrid
HGSEPS1511459310809762 12551915 Co-fractionation; Reconstituted Complex; Two-hybrid
HGSESRRG11459319019082 Reconstituted Complex
HGSESRRG10840719019082 Reconstituted Complex
HGSGFAP11459319019082 Reconstituted Complex
HGSGFAP10893819019082 Reconstituted Complex
HGSHSPA811459319019082 Reconstituted Complex
HGSHSPA810954419019082 Reconstituted Complex
HGSIL2RB10977518445679 Affinity Capture-Western; Reconstituted Complex
HGSIL2RB11459318445679 Affinity Capture-Western; Reconstituted Complex
HGSKRT1811007316189514 Two-hybrid
HGSKRT1811459316189514 Two-hybrid
HGSKRT1911007816189514 Two-hybrid
HGSKRT1911459316189514 Two-hybrid
HGSMAT2A11459319019082 Reconstituted Complex
HGSMAT2A11031419019082 Reconstituted Complex
HGSMEST11459319019082 Reconstituted Complex
HGSMEST11039019019082 Reconstituted Complex
HGSMAP3K1011044019019082 Reconstituted Complex
HGSMAP3K1011459319019082 Reconstituted Complex
HGSNEDD411081112230472 Biochemical Activity
HGSNEDD411459312230472 Biochemical Activity
HGSNEDD811081516735510 Affinity Capture-Western
HGSNEDD811459316735510 Affinity Capture-Western
HGSNF211459310861283 11285248 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HGSNF211084410861283 11285248 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HGSPAK111109511397816 Reconstituted Complex
HGSPAK111459311397816 Reconstituted Complex
HGSPFKM11123419019082 Reconstituted Complex
HGSPFKM11459319019082 Reconstituted Complex
HGSPPP1R711459319019082 Reconstituted Complex
HGSPPP1R711150219019082 Reconstituted Complex
HGSRPS3A11210319019082 Reconstituted Complex
HGSRPS3A11459319019082 Reconstituted Complex
HGSRSU111216419019082 Reconstituted Complex
HGSRSU111459319019082 Reconstituted Complex
HGSSNX111252511110793 Reconstituted Complex
HGSSNX111459311110793 Reconstituted Complex
HGSSTXBP111268119019082 Reconstituted Complex
HGSSTXBP111459319019082 Reconstituted Complex
HGSTADA2A11273416189514 Two-hybrid
HGSTADA2A11459316189514 Two-hybrid
HGSMAP3K711274811397816 Reconstituted Complex
HGSMAP3K711459311397816 Reconstituted Complex
HGSTSG10111310212802020 16189514 Affinity Capture-Western; Two-hybrid
HGSTSG10111459312802020 16189514 Affinity Capture-Western; Two-hybrid
HGSTUBB2A11313119019082 Reconstituted Complex
HGSTUBB2A11459319019082 Reconstituted Complex
HGSUBC11316414602072 16735510 16771824 17101784 Affinity Capture-Western
HGSUBC11459314602072 16735510 16771824 17101784 Affinity Capture-Western
HGSUBA111316519019082 Reconstituted Complex
HGSUBA111459319019082 Reconstituted Complex
HGSUBE2I11317716189514 Two-hybrid
HGSUBE2I11459316189514 Two-hybrid
HGSSTAM1137229407053 12551915 16189514 Affinity Capture-Western; Co-fractionation; Two-hybrid
HGSSTAM1145939407053 12551915 16189514 Affinity Capture-Western; Co-fractionation; Two-hybrid
HGSCASK11459319019082 Reconstituted Complex
HGSCASK11414119019082 Reconstituted Complex
HGSHAP111448012021262 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HGSHAP111459312021262 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HGSNMI11456116189514 Two-hybrid
HGSNMI11459316189514 Two-hybrid
STAM2HGS11459312551915 16189514 Affinity Capture-Western; Co-fractionation; Two-hybrid
STAM2HGS11554812551915 16189514 Affinity Capture-Western; Co-fractionation; Two-hybrid
VPS4AHGS11805914602072 Affinity Capture-Western
VPS4AHGS11459314602072 Affinity Capture-Western
ITCHHGS11459314602072 Affinity Capture-Western
ITCHHGS12374714602072 Affinity Capture-Western
VPS37CHGS11459315509564 Two-hybrid
VPS37CHGS12037115509564 Two-hybrid
EHMT2HGS11459316189514 Two-hybrid
EHMT2HGS11612316189514 Two-hybrid
EXOC8HGS12720616189514 Two-hybrid
EXOC8HGS11459316189514 Two-hybrid
EXOC7HGS11459316189514 Two-hybrid
EXOC7HGS11686716189514 Two-hybrid
LDOC1HGS11716916189514 Two-hybrid
LDOC1HGS11459316189514 Two-hybrid
UBQLN1HGS11900716189514 Two-hybrid
UBQLN1HGS11459316189514 Two-hybrid
C1orf190HGS11459316189514 Two-hybrid
C1orf190HGS13907116189514 Two-hybrid
MIF4GDHGS11459316189514 Two-hybrid
MIF4GDHGS12151116189514 Two-hybrid
BEGAINHGS12164716189514 Two-hybrid
BEGAINHGS11459316189514 Two-hybrid
CCDC33HGS11459316189514 Two-hybrid
CCDC33HGS12312616189514 Two-hybrid
GKAP1HGS12323116189514 Two-hybrid
GKAP1HGS11459316189514 Two-hybrid
USHBP1HGS11459316189514 Two-hybrid
USHBP1HGS12379116189514 Two-hybrid
MED7HGS11459316189514 Two-hybrid
MED7HGS11483316189514 Two-hybrid
DAZAP2HGS11459316189514 Two-hybrid
DAZAP2HGS11514316189514 Two-hybrid
TRAP1HGS11543519019082 Reconstituted Complex
TRAP1HGS11459319019082 Reconstituted Complex
DCTN2HGS11459319019082 Reconstituted Complex
DCTN2HGS11579419019082 Reconstituted Complex
AHCYL1HGS11459319019082 Reconstituted Complex
AHCYL1HGS11598719019082 Reconstituted Complex
OSBPL5HGS12538019019082 Reconstituted Complex
OSBPL5HGS11459319019082 Reconstituted Complex
TUBBHGS12844419019082 Reconstituted Complex
TUBBHGS11459319019082 Reconstituted Complex
RHOBTB3HGS11459319019082 Reconstituted Complex
RHOBTB3HGS11651019019082 Reconstituted Complex
GGA2HGS11459319019082 Reconstituted Complex
GGA2HGS11669719019082 Reconstituted Complex
ARL6IP1HGS11459319019082 Reconstituted Complex
ARL6IP1HGS11681219019082 Reconstituted Complex
SF3B3HGS11459319019082 Reconstituted Complex
SF3B3HGS11701619019082 Reconstituted Complex
PLD3HGS11717319019082 Reconstituted Complex
PLD3HGS11459319019082 Reconstituted Complex
SUN2HGS11459319019082 Reconstituted Complex
SUN2HGS11731219019082 Reconstituted Complex
MTHFD1LHGS11459319019082 Reconstituted Complex
MTHFD1LHGS11740919019082 Reconstituted Complex
FAM5CHGS11459319019082 Reconstituted Complex
FAM5CHGS13089119019082 Reconstituted Complex
NCRNA00265HGS13154719019082 Reconstituted Complex
NCRNA00265HGS11459319019082 Reconstituted Complex
C3orf1HGS11459319019082 Reconstituted Complex
C3orf1HGS11945119019082 Reconstituted Complex
PTCD3HGS11459319019082 Reconstituted Complex
PTCD3HGS12036619019082 Reconstituted Complex
ZNF302HGS11459319019082 Reconstituted Complex
ZNF302HGS12098719019082 Reconstituted Complex
MARK4HGS11459319019082 Reconstituted Complex
MARK4HGS12176019019082 Reconstituted Complex
ILKAPHGS11459319019082 Reconstituted Complex
ILKAPHGS12334319019082 Reconstituted Complex
TMEM49HGS11459319019082 Reconstituted Complex
TMEM49HGS12356719019082 Reconstituted Complex
PPP1R16AHGS12441419019082 Reconstituted Complex
PPP1R16AHGS11459319019082 Reconstituted Complex
TJP2HGS11480919019082 Reconstituted Complex
TJP2HGS11459319019082 Reconstituted Complex
SCRN1HGS11459319019082 Reconstituted Complex
SCRN1HGS11514519019082 Reconstituted Complex
TMCC2HGS11524019019082 Reconstituted Complex
TMCC2HGS11459319019082 Reconstituted Complex
HNRPDLHGS11530819019082 Reconstituted Complex
HNRPDLHGS11459319019082 Reconstituted Complex
SCAMP3HGS11459319158374 Affinity Capture-Western
SCAMP3HGS11537819158374 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:104681
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-6107'