AutismKB 2.0

Annotation Details for EXO1


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Basic Information Top
Gene Symbol:EXO1 ( HEX1,hExoI )
Gene Full Name: exonuclease 1
Band: 1q43
Quick LinksEntrez ID:9156; OMIM: 606063; Uniprot ID:EXO1_HUMAN; ENSEMBL ID: ENSG00000174371; HGNC ID: 3511
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus11429708
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0016604IDA-nuclear body-
GO ID Evidence Qualifier GO_term References
GO:0003677IDA-DNA binding11842105
GO:0003682IEA-chromatin binding-
GO:0004523TAS-RNA-DNA hybrid ribonuclease activity10364235
GO:0004527TAS-exonuclease activity9788596
GO:0005515IPI-protein binding2414623
GO:0008409ISS-5'-3' exonuclease activity9685493
GO:0008409TAS-5'-3' exonuclease activity-
GO:0035312IDA-5'-3' exodeoxyribonuclease activity10608837
GO:0045145IDA-single-stranded DNA 5'-3' exodeoxyribonuclease activity10608837
GO:0046872IEA-metal ion binding-
GO:0048256IDA-flap endonuclease activity10608837
GO:0051908IDA-double-stranded DNA 5'-3' exodeoxyribonuclease activity10608837
GO ID Evidence Qualifier GO_term References
GO:0000731TAS-DNA synthesis involved in DNA repair-
GO:0000732TAS-strand displacement-
GO:0002455IEA-humoral immune response mediated by circulating immunoglobulin-
GO:0006260TAS-DNA replication-
GO:0006281TAS-DNA repair10364235
GO:0006298IDA-mismatch repair14636568
GO:0006298IMP-mismatch repair11809771
GO:0006298IPI-mismatch repair9788596
GO:0006298ISS-mismatch repair9685493
GO:0006298TAS-mismatch repair-
GO:0006310IGI-DNA recombination10364235
GO:0016446IEA-somatic hypermutation of immunoglobulin genes-
GO:0045190IEA-isotype switching-
GO:0051321IEA-meiotic cell cycle-
GO:0090502IEA-RNA phosphodiester bond hydrolysis, endonucleolytic-
GO:0090656TAS-t-circle formation27918544
GO:1901796TAS-regulation of signal transduction by p53 class mediator-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
EXO1BLM11460218971343 Affinity Capture-Western
EXO1BLM10711018971343 Affinity Capture-Western
EXO1MLH111043811427529 17148452 19015241 Affinity Capture-MS; Affinity Capture-Western; Protein-peptide; Reconstituted Complex
EXO1MLH111460211427529 17148452 19015241 Affinity Capture-MS; Affinity Capture-Western; Protein-peptide; Reconstituted Complex
EXO1MSH21146029788596 10856833 11427529 19015241 Reconstituted Complex; Two-hybrid
EXO1MSH21105739788596 10856833 11427529 19015241 Reconstituted Complex; Two-hybrid
EXO1MSH311460211427529 Reconstituted Complex
EXO1MSH311057411427529 Reconstituted Complex
EXO1PMS111460217148452 Affinity Capture-Western
EXO1PMS111139117148452 Affinity Capture-Western
EXO1PMS211460211427529 17148452 Affinity Capture-MS; Affinity Capture-Western
EXO1PMS211140411427529 17148452 Affinity Capture-MS; Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1349427
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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