Annotation Details for NLRP12
Basic Information Top
| Gene Symbol: | NLRP12 ( CLR19.3,FCAS2,NALP12,PAN6,PYPAF7,RNO,RNO2 ) |
|---|---|
| Gene Full Name: | NLR family, pyrin domain containing 12 |
| Band: | 19q13.42 |
| Quick Links | Entrez ID:91662; OMIM: 609648; Uniprot ID:NAL12_HUMAN; ENSEMBL ID: ENSG00000142405; HGNC ID: 22938 |
| Relate to Another Database: | SFARIGene; denovo-db |
| GO ID | Evidence | Qualifier | GO_term | References |
|---|---|---|---|---|
| GO:0005634 | IDA | NOT | nucleus | 12019269 |
| GO:0005737 | IDA | - | cytoplasm | 12019269 |
| GO ID | Evidence | Qualifier | GO_term | References |
|---|---|---|---|---|
| GO:0005515 | IPI | - | protein binding | 12019269 |
| GO:0005524 | IEA | - | ATP binding | - |
| GO:0008656 | NAS | - | cysteine-type endopeptidase activator activity involved in apoptotic process | 12019269 |
| GO ID | Evidence | Qualifier | GO_term | References |
|---|---|---|---|---|
| GO:0006919 | NAS | - | activation of cysteine-type endopeptidase activity involved in apoptotic process | 12019269 |
| GO:0007165 | NAS | - | signal transduction | 12019269 |
| GO:0008588 | IDA | - | release of cytoplasmic sequestered NF-kappaB | 12019269 |
| GO:0009968 | IDA | - | negative regulation of signal transduction | 16203735 |
| GO:0031953 | IDA | - | negative regulation of protein autophosphorylation | 16203735 |
| GO:0032088 | IDA | - | negative regulation of NF-kappaB transcription factor activity | 18230725 |
| GO:0036336 | IEA | - | dendritic cell migration | - |
| GO:0043122 | IDA | - | regulation of I-kappaB kinase/NF-kappaB signaling | 12019269 |
| GO:0043124 | IDA | - | negative regulation of I-kappaB kinase/NF-kappaB signaling | 16203735 |
| GO:0043281 | IDA | - | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 12019269 |
| GO:0045345 | IDA | - | positive regulation of MHC class I biosynthetic process | 12759408 |
| GO:0045381 | NAS | - | regulation of interleukin-18 biosynthetic process | 12019269 |
| GO:0045409 | IDA | - | negative regulation of interleukin-6 biosynthetic process | 16203735 |
| GO:0045751 | IDA | - | negative regulation of Toll signaling pathway | 16203735 |
| GO:0050710 | IDA | - | negative regulation of cytokine secretion | 16203735 |
| GO:0050711 | IDA | - | negative regulation of interleukin-1 secretion | 16203735 |
| GO:0050718 | NAS | - | positive regulation of interleukin-1 beta secretion | 12019269 |
| GO:0050728 | IMP | - | negative regulation of inflammatory response | 18230725 |
| GO:0050729 | NAS | - | positive regulation of inflammatory response | 12019269 |
| GO:0070373 | IEA | - | negative regulation of ERK1 and ERK2 cascade | - |
| GO:0071345 | IEA | - | cellular response to cytokine stimulus | - |
| GO:1901223 | IEA | - | negative regulation of NIK/NF-kappaB signaling | - |
Protein-Protein Interaction