AutismKB 2.0

Annotation Details for ACVR2A


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Basic Information Top
Gene Symbol:ACVR2A ( ACTRII,ACVR2 )
Gene Full Name: activin A receptor, type IIA
Band: 2q22.3-q23.1
Quick LinksEntrez ID:92; OMIM: 102581; Uniprot ID:AVR2A_HUMAN; ENSEMBL ID: ENSG00000121989; HGNC ID: 173
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm14738881
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane1314589
GO:0009986IEA-cell surface-
GO:0034673IDA-inhibin-betaglycan-ActRII complex10746731
GO:0043235IPI-receptor complex9872992
GO ID Evidence Qualifier GO_term References
GO:0004674EXP-protein serine/threonine kinase activity8622651
GO:0004675TAS-transmembrane receptor protein serine/threonine kinase activity1314589
GO:0004702IEA-signal transducer, downstream of receptor, with serine/threonine kinase activity-
GO:0005515IPI-protein binding8242742
GO:0005515IPIcontributes_toprotein binding10746731
GO:0005524IEA-ATP binding-
GO:0015026IDA-coreceptor activity10746731
GO:0017002IDAcontributes_toactivin-activated receptor activity12665502
GO:0019838IEA-growth factor binding-
GO:0030165IEA-PDZ domain binding-
GO:0034711IEA-inhibin binding-
GO:0043621IEA-protein self-association-
GO:0046872IEA-metal ion binding-
GO:0048185IPIcontributes_toactivin binding9032295
GO:0098821ISS-BMP receptor activity-
GO ID Evidence Qualifier GO_term References
GO:0001702IEA-gastrulation with mouth forming second-
GO:0001934IMP-positive regulation of protein phosphorylation17472960
GO:0007178TAS-transmembrane receptor protein serine/threonine kinase signaling pathway1314589
GO:0007283IEA-spermatogenesis-
GO:0007368IEA-determination of left/right symmetry-
GO:0007498IEA-mesoderm development-
GO:0009952IEA-anterior/posterior pattern specification-
GO:0010862IMP-positive regulation of pathway-restricted SMAD protein phosphorylation19366699
GO:0023014IEA-signal transduction by protein phosphorylation-
GO:0030501IMP-positive regulation of bone mineralization18436533
GO:0030509IDA-BMP signaling pathway18436533
GO:0030509IMP-BMP signaling pathway17472960
GO:0030509TAS-BMP signaling pathway-
GO:0030510IEA-regulation of BMP signaling pathway-
GO:0032924IMP-activin receptor signaling pathway12665502
GO:0032927IDA-positive regulation of activin receptor signaling pathway12665502
GO:0042713IEA-sperm ejaculation-
GO:0043084IEA-penile erection-
GO:0045648IDA-positive regulation of erythrocyte differentiation9032295
GO:0045669IMP-positive regulation of osteoblast differentiation18436533
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter18326817
GO:0048706IEA-embryonic skeletal system development-
GO:0050999IEA-regulation of nitric-oxide synthase activity-
GO:0060011IEA-Sertoli cell proliferation-
GO:0071773IMP-cellular response to BMP stimulus18326817
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ACVR2AACVR1B1066068612709 9892009 Affinity Capture-Western
ACVR2AACVR1B1066078612709 9892009 Affinity Capture-Western
GDF5ACVR2A1138398702914 Affinity Capture-Western
GDF5ACVR2A1066078702914 Affinity Capture-Western
INHBAACVR2A1098369202237 10746731 Affinity Capture-Western
INHBAACVR2A1066079202237 10746731 Affinity Capture-Western
INHBBACVR2A1098379202237 Affinity Capture-Western
INHBBACVR2A1066079202237 Affinity Capture-Western
BMP7ACVR2A1066079748228 Affinity Capture-Western
BMP7ACVR2A1071239748228 Affinity Capture-Western
ENGACVR2A1066079872992 Affinity Capture-Western
ENGACVR2A1083379872992 Affinity Capture-Western
BMP6ACVR2A10660710504300 Affinity Capture-Western
BMP6ACVR2A10712210504300 Affinity Capture-Western
INHAACVR2A10983510746731 Affinity Capture-Western
INHAACVR2A10660710746731 Affinity Capture-Western
SYNJ2BPACVR2A12061411882656 15451561 Reconstituted Complex; Two-hybrid
SYNJ2BPACVR2A10660711882656 15451561 Reconstituted Complex; Two-hybrid
MAGI2ACVR2A11519715451561 Two-hybrid
MAGI2ACVR2A10660715451561 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:102806
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-980526-227'