AutismKB 2.0

Annotation Details for NOG


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Basic Information Top
Gene Symbol:NOG ( SYM1,SYNS1 )
Gene Full Name: noggin
Band: 17q22
Quick LinksEntrez ID:9241; OMIM: 602991; Uniprot ID:NOGG_HUMAN; ENSEMBL ID: ENSG00000183691; HGNC ID: 7866
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space7666191
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding19804412
GO:0019955IPI-cytokine binding8752214
GO:0042803IDA-protein homodimerization activity11562478
GO ID Evidence Qualifier GO_term References
GO:0000122ISS-negative regulation of transcription from RNA polymerase II promoter-
GO:0001501TAS-skeletal system development10080184
GO:0001649ISS-osteoblast differentiation10780858
GO:0001701IEA-in utero embryonic development-
GO:0001706IEA-endoderm formation-
GO:0001707IEA-mesoderm formation-
GO:0001837ISS-epithelial to mesenchymal transition10780858
GO:0001839IEA-neural plate morphogenesis-
GO:0001843IEA-neural tube closure-
GO:0003149ISS-membranous septum morphogenesis-
GO:0003151ISS-outflow tract morphogenesis-
GO:0003203ISS-endocardial cushion morphogenesis-
GO:0003223ISS-ventricular compact myocardium morphogenesis-
GO:0007399TAS-nervous system development7666191
GO:0008045IEA-motor neuron axon guidance-
GO:0009953IDA-dorsal/ventral pattern formation7666191
GO:0010628ISS-positive regulation of gene expression-
GO:0021510IEA-spinal cord development-
GO:0021533IMP-cell differentiation in hindbrain8582276
GO:0021983IEA-pituitary gland development-
GO:0030336IDA-negative regulation of cell migration20675382
GO:0030509TAS-BMP signaling pathway-
GO:0030514IDA-negative regulation of BMP signaling pathway8752214
GO:0030514ISS-negative regulation of BMP signaling pathway-
GO:0035019IMP-somatic stem cell population maintenance17889703
GO:0042060ISS-wound healing10780858
GO:0042474IMP-middle ear morphogenesis10080184
GO:0042733IMP-embryonic digit morphogenesis10080184
GO:0045668IDA-negative regulation of osteoblast differentiation20675382
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0048318IEA-axial mesoderm development-
GO:0048570IEA-notochord morphogenesis-
GO:0048706IMP-embryonic skeletal system development10080184
GO:0048712ISS-negative regulation of astrocyte differentiation10780858
GO:0050679IEA-positive regulation of epithelial cell proliferation-
GO:0051216IEA-cartilage development-
GO:0055009ISS-atrial cardiac muscle tissue morphogenesis-
GO:0060044ISS-negative regulation of cardiac muscle cell proliferation10780858
GO:0060173IMP-limb development10080184
GO:0060272IMP-embryonic skeletal joint morphogenesis16151340
GO:0060302IDA-negative regulation of cytokine activity8752214
GO:0060325IEA-face morphogenesis-
GO:0060394IDA-negative regulation of pathway-restricted SMAD protein phosphorylation15539560
GO:0060394ISS-negative regulation of pathway-restricted SMAD protein phosphorylation-
GO:0060412ISS-ventricular septum morphogenesis-
GO:0060425IEA-lung morphogenesis-
GO:0060513IEA-prostatic bud formation-
GO:0060676IEA-ureteric bud formation-
GO:0060825IMP-fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation8582276
GO:0061037IEA-negative regulation of cartilage development-
GO:0061053IEA-somite development-
GO:0061312ISS-BMP signaling pathway involved in heart development-
GO:0061384ISS-heart trabecula morphogenesis-
GO:0061626ISS-pharyngeal arch artery morphogenesis-
GO:0090090IDA-negative regulation of canonical Wnt signaling pathway15539560
GO:0090190ISS-positive regulation of branching involved in ureteric bud morphogenesis-
GO:0090193ISS-positive regulation of glomerulus development-
GO:1905006ISS-negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation-
GO:2000313IMP-regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation8582276
GO:2001234IEA-negative regulation of apoptotic signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NOGBMP711466812478285 Co-crystal Structure; Reconstituted Complex
NOGBMP710712312478285 Co-crystal Structure; Reconstituted Complex
NOGNOG11466812478285 Co-purification
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:104327
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-990714-8'