AutismKB 2.0

Annotation Details for ITGB1BP1


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Basic Information Top
Gene Symbol:ITGB1BP1 ( DKFZp686K08158,ICAP-1A,ICAP-1B,ICAP-1alpha,ICAP1,ICAP1A,ICAP1B )
Gene Full Name: integrin beta 1 binding protein 1
Band: 2p25.1
Quick LinksEntrez ID:9270; OMIM: 607153; Uniprot ID:ITBP1_HUMAN; ENSEMBL ID: ENSG00000119185; HGNC ID: 23927
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001726IDA-ruffle11919189
GO:0005634IDA-nucleus12473654
GO:0005654IDA-nucleoplasm-
GO:0005737IDA-cytoplasm11919189
GO:0005829IDA-cytosol11919189
GO:0005856ISS-cytoskeleton-
GO:0005886ISS-plasma membrane-
GO:0005925IDANOTfocal adhesion11919189
GO:0016020NAS-membrane9281591
GO:0030027IDA-lamellipodium11919189
GO:0048471IDA-perinuclear region of cytoplasm11919189
GO:0070062IDA-extracellular exosome23376485
GO:0071944IDA-cell periphery11919189
GO ID Evidence Qualifier GO_term References
GO:0005092IDA-GDP-dissociation inhibitor activity11807099
GO:0005178IDA-integrin binding15703214
GO:0005178IPI-integrin binding12473654
GO:0005515IPI-protein binding9281591
GO:0008565IDA-protein transporter activity17916086
GO:0019901IEA-protein kinase binding-
GO:0032403IDA-protein complex binding17916086
GO ID Evidence Qualifier GO_term References
GO:0002043IDA-blood vessel endothelial cell proliferation involved in sprouting angiogenesis20616313
GO:0006351IEA-transcription, DNA-templated-
GO:0006469IDA-negative regulation of protein kinase activity20616313
GO:0006933ISS-negative regulation of cell adhesion involved in substrate-bound cell migration-
GO:0007160IDA-cell-matrix adhesion9281591
GO:0007219IEA-Notch signaling pathway-
GO:0007229IDA-integrin-mediated signaling pathway11919189
GO:0008284IDA-positive regulation of cell proliferation15703214
GO:0008285IDA-negative regulation of cell proliferation20616313
GO:0010595IDA-positive regulation of endothelial cell migration20616313
GO:0010764ISS-negative regulation of fibroblast migration-
GO:0015031IDA-protein transport17916086
GO:0016477TAS-cell migration11919189
GO:0030154IEA-cell differentiation-
GO:0031214IEA-biomineral tissue development-
GO:0032091IDA-negative regulation of protein binding12473654
GO:0032148IDA-activation of protein kinase B activity20616313
GO:0033622ISS-integrin activation-
GO:0033628ISS-regulation of cell adhesion mediated by integrin-
GO:0035148IDA-tube formation20616313
GO:0035556TAS-intracellular signal transduction9813144
GO:0035924IDA-cellular response to vascular endothelial growth factor stimulus20616313
GO:0043087IDA-regulation of GTPase activity11807099
GO:0043113ISS-receptor clustering-
GO:0044344IDA-cellular response to fibroblast growth factor stimulus20616313
GO:0045747IDA-positive regulation of Notch signaling pathway20616313
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter15703214
GO:0050880IDA-regulation of blood vessel size20616313
GO:0051451ISS-myoblast migration-
GO:0051496ISS-positive regulation of stress fiber assembly-
GO:0051781IEA-positive regulation of cell division-
GO:0051894IEA-positive regulation of focal adhesion assembly-
GO:0051895IDA-negative regulation of focal adhesion assembly12473654
GO:0051897IDA-positive regulation of protein kinase B signaling20616313
GO:0070373IDA-negative regulation of ERK1 and ERK2 cascade20616313
GO:0090051IDA-negative regulation of cell migration involved in sprouting angiogenesis20616313
GO:0090314ISS-positive regulation of protein targeting to membrane-
GO:0090315IDA-negative regulation of protein targeting to membrane11807099
GO:1900025IDA-negative regulation of substrate adhesion-dependent cell spreading11807099
GO:2001044ISS-regulation of integrin-mediated signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ITGB1BP1KRIT111468911741838 11854171 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ITGB1BP1KRIT110733011741838 11854171 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ITGB1BP1ITGB11146899281591 11741908 Affinity Capture-Western; Reconstituted Complex
ITGB1BP1ITGB11098949281591 11741908 Affinity Capture-Western; Reconstituted Complex
ITGB1BP1LRP111468910827173 Reconstituted Complex; Two-hybrid
ITGB1BP1LRP111021510827173 Reconstituted Complex; Two-hybrid
ITGB1BP1LRP211021610827173 Reconstituted Complex; Two-hybrid
ITGB1BP1LRP211468910827173 Reconstituted Complex; Two-hybrid
ITGB1BP1LRP811468910827173 Two-hybrid
ITGB1BP1LRP811357910827173 Two-hybrid
TANKITGB1BP11146898710854 Affinity Capture-Western
TANKITGB1BP11153288710854 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1306802
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-051113-264'