AutismKB 2.0

Annotation Details for SLIT2


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Basic Information Top
Gene Symbol:SLIT2 ( FLJ14420,SLIL3,Slit-2 )
Gene Full Name: slit homolog 2 (Drosophila)
Band: 4p15.31
Quick LinksEntrez ID:9353; OMIM: 603746; Uniprot ID:SLIT2_HUMAN; ENSEMBL ID: ENSG00000145147; HGNC ID: 11086
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space16439689
GO:0005737IDA-cytoplasm18566128
GO:0005886TAS-plasma membrane-
GO:0016020NAS-membrane16439689
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0005095IDA-GTPase inhibitor activity16439689
GO:0005509NAS-calcium ion binding9813312
GO:0005515IPI-protein binding10102268
GO:0008201IDA-heparin binding17062560
GO:0042802IPI-identical protein binding19498462
GO:0042803IDA-protein homodimerization activity19498462
GO:0043237IDA-laminin-1 binding10102268
GO:0043394IPI-proteoglycan binding11375980
GO:0048495IPI-Roundabout binding10102268
GO ID Evidence Qualifier GO_term References
GO:0001657IMP-ureteric bud development15130495
GO:0001933IDA-negative regulation of protein phosphorylation18345009
GO:0002042IMP-cell migration involved in sprouting angiogenesis19351956
GO:0002689IDA-negative regulation of leukocyte chemotaxis11309622
GO:0007411IDA-axon guidance11748139
GO:0007411TAS-axon guidance-
GO:0008045IDA-motor neuron axon guidance10102268
GO:0010593IDA-negative regulation of lamellipodium assembly16439689
GO:0010596IDA-negative regulation of endothelial cell migration18345009
GO:0014912IDA-negative regulation of smooth muscle cell migration16439689
GO:0021834IDANOTchemorepulsion involved in embryonic olfactory bulb interneuron precursor migration11748139
GO:0021836IDA-chemorepulsion involved in postnatal olfactory bulb interneuron migration15207848
GO:0021972IMP-corticospinal neuron axon guidance through spinal cord10975526
GO:0030308IMP-negative regulation of cell growth18829537
GO:0030336IDA-negative regulation of cell migration19005219
GO:0030336IMP-negative regulation of cell migration18566128
GO:0030837IDA-negative regulation of actin filament polymerization19759280
GO:0031290IDA-retinal ganglion cell axon guidance10864954
GO:0032870IEP-cellular response to hormone stimulus18566128
GO:0034260IEA-negative regulation of GTPase activity-
GO:0035385IC-Roundabout signaling pathway10102268
GO:0035385IMP-Roundabout signaling pathway18829537
GO:0043065IMP-positive regulation of apoptotic process18566128
GO:0043116IDA-negative regulation of vascular permeability18345009
GO:0048754IDA-branching morphogenesis of an epithelial tube18345009
GO:0048754IMP-branching morphogenesis of an epithelial tube19005219
GO:0048846IDA-axon extension involved in axon guidance16840550
GO:0050772TAS-positive regulation of axonogenesis10197527
GO:0050919IDA-negative chemotaxis11748139
GO:0050919IMP-negative chemotaxis19005219
GO:0050929IDA-induction of negative chemotaxis10197527
GO:0051058IDA-negative regulation of small GTPase mediated signal transduction16439689
GO:0051414IEP-response to cortisol18566128
GO:0061364IEP-apoptotic process involved in luteolysis18566128
GO:0070100IMP-negative regulation of chemokine-mediated signaling pathway18829537
GO:0071504IDA-cellular response to heparin17062560
GO:0071672IDA-negative regulation of smooth muscle cell chemotaxis16439689
GO:0071676IDA-negative regulation of mononuclear cell migration16439689
GO:0090024IDA-negative regulation of neutrophil chemotaxis19759280
GO:0090027ISS-negative regulation of monocyte chemotaxis-
GO:0090260IDA-negative regulation of retinal ganglion cell axon guidance17062560
GO:0090288IDA-negative regulation of cellular response to growth factor stimulus16439689
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SLIT2GPC110907911375980 Affinity Capture-Western; Reconstituted Complex
SLIT2GPC111475611375980 Affinity Capture-Western; Reconstituted Complex
ROBO4SLIT212002512941633 Affinity Capture-Western
ROBO4SLIT211475612941633 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1315205
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-010306-3'