AutismKB 2.0

Annotation Details for NRXN3


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Basic Information Top
Gene Symbol:NRXN3 ( C14orf60,KIAA0743,MGC176711 )
Gene Full Name: neurexin 3
Band: 14q24.3-q31.1
Quick LinksEntrez ID:9369; OMIM: 600567; Uniprot ID:NRX3A_HUMAN; ENSEMBL ID: ENSG00000021645; HGNC ID: 8010
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane1621094
GO:0098793IEA-presynapse-
GO ID Evidence Qualifier GO_term References
GO:0004872TAS-receptor activity1621094
GO:0046872IEA-metal ion binding-
GO:0050839TAS-cell adhesion molecule binding18923512
GO:0097109TAS-neuroligin family protein binding18923512
GO ID Evidence Qualifier GO_term References
GO:0007158TAS-neuron cell-cell adhesion18923512
GO:0007269IEA-neurotransmitter secretion-
GO:0007411TAS-axon guidance1621094
GO:0007416IEA-synapse assembly-
GO:0007612IGI-learning22209245
GO:0030534IGI-adult behavior22209245
GO:0035176IGI-social behavior22209245
GO:0051965IEA-positive regulation of synapse assembly-
GO:0071625IGI-vocalization behavior22209245
GO:0090129IEA-positive regulation of synapse maturation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NRXN3MLLT41147709707552 Two-hybrid
NRXN3MLLT41104479707552 Two-hybrid
NLGN1NRXN31147708576240 Reconstituted Complex
NLGN1NRXN31165388576240 Reconstituted Complex
NLGN3NRXN31147708576240 Reconstituted Complex
NLGN3NRXN31199448576240 Reconstituted Complex
NLGN2NRXN31147708576240 Reconstituted Complex
NLGN2NRXN31216118576240 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
NRXN3rs1004212, rs2221299, rs2288140, rs760288 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1096389
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070206-10'