AutismKB 2.0

Annotation Details for NRXN1


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Basic Information Top
Gene Symbol:NRXN1 ( DKFZp313P2036,FLJ35941,Hs.22998,KIAA0578,PTHSL2 )
Gene Full Name: neurexin 1
Band: 2p16.3
Quick LinksEntrez ID:9378; OMIM: 600565; Uniprot ID:NRX1A_HUMAN; ENSEMBL ID: ENSG00000179915; HGNC ID: 8008
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005783ISS-endoplasmic reticulum-
GO:0005886IC-plasma membrane21424692
GO:0005886ISS-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane1621094
GO:0009986IDA-cell surface21424692
GO:0030054IEA-cell junction-
GO:0031965ISS-nuclear membrane-
GO:0031982ISS-vesicle-
GO:0042734ISS-presynaptic membrane-
GO:0043025ISS-neuronal cell body-
GO:0043234IEA-protein complex-
GO ID Evidence Qualifier GO_term References
GO:0004872TAS-receptor activity1621094
GO:0005246ISS-calcium channel regulator activity-
GO:0005509ISS-calcium ion binding-
GO:0005515IPI-protein binding11152476
GO:0033130ISS-acetylcholine receptor binding-
GO:0050839ISS-cell adhesion molecule binding-
GO:0097109ISS-neuroligin family protein binding-
GO ID Evidence Qualifier GO_term References
GO:0007158TAS-neuron cell-cell adhesion18923512
GO:0007268ISS-chemical synaptic transmission-
GO:0007269ISS-neurotransmitter secretion-
GO:0007411TAS-axon guidance1621094
GO:0007416ISS-synapse assembly-
GO:0007612IMP-learning19896112
GO:0030534IMP-adult behavior19896112
GO:0035176IMP-social behavior18057082
GO:0042297IMP-vocal learning19896112
GO:0050885IMPNOTneuromuscular process controlling balance19896112
GO:0050885ISS-neuromuscular process controlling balance19822762
GO:0051965ISS-positive regulation of synapse assembly-
GO:0051968ISS-positive regulation of synaptic transmission, glutamatergic19822762
GO:0060134IEA-prepulse inhibition-
GO:0061178IEA-regulation of insulin secretion involved in cellular response to glucose stimulus-
GO:0065009IEA-regulation of molecular function-
GO:0071625IMP-vocalization behavior18057082
GO:0090129ISS-positive regulation of synapse maturation-
GO:0097104ISS-postsynaptic membrane assembly-
GO:0097116ISS-gephyrin clustering involved in postsynaptic density assembly-
GO:0097118ISS-neuroligin clustering involved in postsynaptic membrane assembly-
GO:0097119ISS-postsynaptic density protein 95 clustering-
GO:2000463ISS-positive regulation of excitatory postsynaptic potential19822762
GO:2000821IEA-regulation of grooming behavior-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NRXN1MLLT41147799707552 Two-hybrid
NRXN1MLLT41104479707552 Two-hybrid
NLGN1NRXN11147798576240 14522992 Reconstituted Complex
NLGN1NRXN11165388576240 14522992 Reconstituted Complex
NLGN3NRXN11147798576240 Reconstituted Complex
NLGN3NRXN11199448576240 Reconstituted Complex
NLGN2NRXN11216118576240 Reconstituted Complex
NLGN2NRXN11147798576240 Reconstituted Complex
SYT13NRXN112163811171101 Reconstituted Complex
SYT13NRXN111477911171101 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
NRXN1rs10490162, rs12467557, rs12623467, rs1400882, rs17040897, rs17041112, rs2287235 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1096391
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070206-1'