AutismKB 2.0

Annotation Details for GRAP2


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Basic Information Top
Gene Symbol:GRAP2 ( GADS,GRAP-2,GRB2L,GRBLG,GRID,GRPL,GrbX,Grf40,Mona,P38 )
Gene Full Name: GRB2-related adaptor protein 2
Band: 22q13.1
Quick LinksEntrez ID:9402; OMIM: 604518; Uniprot ID:GRAP2_HUMAN; ENSEMBL ID: ENSG00000100351; HGNC ID: 4563
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus21179510
GO:0005737IDA-cytoplasm21179510
GO:0005768IDA-endosome21179510
GO:0005829TAS-cytosol-
GO:0031234IBA-extrinsic component of cytoplasmic side of plasma membrane-
GO ID Evidence Qualifier GO_term References
GO:0004715IBA-non-membrane spanning protein tyrosine kinase activity-
GO:0005070TAS-SH3/SH2 adaptor activity9878555
GO:0005102IBA-receptor binding-
GO:0005515IPI-protein binding12359715
GO ID Evidence Qualifier GO_term References
GO:0007169IBA-transmembrane receptor protein tyrosine kinase signaling pathway-
GO:0007265TAS-Ras protein signal transduction9878555
GO:0007267TAS-cell-cell signaling9878555
GO:0009967IEA-positive regulation of signal transduction-
GO:0016477IBA-cell migration-
GO:0030154IBA-cell differentiation-
GO:0031295TAS-T cell costimulation-
GO:0038083IBA-peptidyl-tyrosine autophosphorylation-
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0042127IBA-regulation of cell proliferation-
GO:0045087IBA-innate immune response-
GO:0050852TAS-T cell receptor signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GRAP2FASLG11479911741599 Reconstituted Complex
GRAP2FASLG10685211741599 Reconstituted Complex
GRAP2CD2811479910820259 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GRAP2CD2810737810820259 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GRAP2CSF1R1078239857184 Reconstituted Complex
GRAP2CSF1R1147999857184 Reconstituted Complex
GRAP2GAB11147999878555 Two-hybrid
GRAP2GAB11088249878555 Two-hybrid
GRAP2GFAP11479916189514 Two-hybrid
GRAP2GFAP10893816189514 Two-hybrid
GRAP2HNRNPK11479916189514 Two-hybrid
GRAP2HNRNPK10943116189514 Two-hybrid
GRAP2LCP211479910021361 10224278 10820259 16189514 Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
GRAP2LCP211012910021361 10224278 10820259 16189514 Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
GRAP2SOS211253810820259 Reconstituted Complex
GRAP2SOS211479910820259 Reconstituted Complex
GRAP2YWHAE11336316189514 Two-hybrid
GRAP2YWHAE11479916189514 Two-hybrid
LATGRAP211479910021361 10224278 Affinity Capture-Western; Reconstituted Complex
LATGRAP211797110021361 10224278 Affinity Capture-Western; Reconstituted Complex
STAMBPGRAP211586310224278 16189514 Two-hybrid
STAMBPGRAP211479910224278 16189514 Two-hybrid
CCNDBP1GRAP211479910801854 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CCNDBP1GRAP211711710801854 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GNB2L1GRAP211479910820259 Reconstituted Complex
GNB2L1GRAP211567110820259 Reconstituted Complex
KHDRBS1GRAP211479910820259 Reconstituted Complex
KHDRBS1GRAP211590010820259 Reconstituted Complex
MAP4K1GRAP211479911313918 Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
MAP4K1GRAP211635411313918 Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
LAX1GRAP211479912359715 Affinity Capture-Western
LAX1GRAP212024612359715 Affinity Capture-Western
RBPMSGRAP211479916189514 Two-hybrid
RBPMSGRAP211622016189514 Two-hybrid
ZBTB7BGRAP211479916189514 Two-hybrid
ZBTB7BGRAP211924216189514 Two-hybrid
BEND5GRAP211479916189514 Two-hybrid
BEND5GRAP212278216189514 Two-hybrid
KRTAP4-12GRAP211479916189514 Two-hybrid
KRTAP4-12GRAP212375616189514 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
GRAP2DNM221652115696170 An unspecified isoform of Dyn2 interacts with Gads. This interaction was modeled on a demonstrated interaction between human Dyn2 and Gads from an unspecified species.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1333842
  • Data Attributes: HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-1485'