AutismKB 2.0

Annotation Details for MED21


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Basic Information Top
Gene Symbol:MED21 ( SRB7,SURB7 )
Gene Full Name: mediator complex subunit 21
Band: 12p12
Quick LinksEntrez ID:9412; OMIM: 603800; Uniprot ID:MED21_HUMAN; ENSEMBL ID: ENSG00000152944; HGNC ID: 11473
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000151IEA-ubiquitin ligase complex-
GO:0016592IDA-mediator complex12037571
GO ID Evidence Qualifier GO_term References
GO:0001104IBA-RNA polymerase II transcription cofactor activity-
GO:0003713IDA-transcription coactivator activity12037571
GO:0003899TAS-DNA-directed 5'-3' RNA polymerase activity8598913
GO:0005515IPI-protein binding14638676
GO:0061630IEA-ubiquitin protein ligase activity-
GO ID Evidence Qualifier GO_term References
GO:0001824IEA-blastocyst development-
GO:0006351IEA-transcription, DNA-templated-
GO:0006357TAS-regulation of transcription from RNA polymerase II promoter8598913
GO:0016567IEA-protein ubiquitination-
GO:0019827IEA-stem cell population maintenance-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter12037571
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MED21BRCA11071409159119 Affinity Capture-Western; Co-purification
MED21BRCA11148079159119 Affinity Capture-Western; Co-purification
MED21CDK71074579315662 Affinity Capture-Western
MED21CDK71148079315662 Affinity Capture-Western
MED21CDK81074589315662 9710619 10198638 11867769 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
MED21CDK81148079315662 9710619 10198638 11867769 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
MED21CREBBP1148079710619 Affinity Capture-Western
MED21CREBBP1077779710619 Affinity Capture-Western
MED21ESR110840311867769 Reconstituted Complex
MED21ESR111480711867769 Reconstituted Complex
MED21ESR211480711867769 Reconstituted Complex
MED21ESR210840411867769 Reconstituted Complex
MED21GTF2B1092149315662 Affinity Capture-Western
MED21GTF2B1148079315662 Affinity Capture-Western
MED21GTF2E11092159159119 Affinity Capture-Western; Co-purification
MED21GTF2E11148079159119 Affinity Capture-Western; Co-purification
MED21GTF2F11092179159119 9315662 Affinity Capture-Western; Co-purification
MED21GTF2F11148079159119 9315662 Affinity Capture-Western; Co-purification
MED21GTF2H41092239159119 Affinity Capture-Western; Co-purification
MED21GTF2H41148079159119 Affinity Capture-Western; Co-purification
MED21HNF4A11480712101254 Reconstituted Complex
MED21HNF4A10941412101254 Reconstituted Complex
MED21POLR2A1114269159119 9315662 9710619 Affinity Capture-Western; Co-fractionation; Co-purification
MED21POLR2A1148079159119 9315662 9710619 Affinity Capture-Western; Co-fractionation; Co-purification
MED21MED111146515989967 Affinity Capture-Western
MED21MED111480715989967 Affinity Capture-Western
MED21TRIM2711191920211142 Two-hybrid
MED21TRIM2711480720211142 Two-hybrid
MED21SMARCB11148079710619 Affinity Capture-Western
MED21SMARCB11124829710619 Affinity Capture-Western
MED21TARBP211275820211142 Two-hybrid
MED21TARBP211480720211142 Two-hybrid
MED21THRA11292310198638 Affinity Capture-Western
MED21THRA11480710198638 Affinity Capture-Western
MED21VDR11326410198638 Affinity Capture-MS
MED21VDR11480710198638 Affinity Capture-MS
MED21KAT2B1143759710619 Affinity Capture-Western
MED21KAT2B1148079710619 Affinity Capture-Western
MED21MED141146999734358 Co-purification
MED21MED141148079734358 Co-purification
TCERG1MED211161209315662 Affinity Capture-Western
TCERG1MED211148079315662 Affinity Capture-Western
MED6MED211148079734358 Co-purification
MED6MED211153199734358 Co-purification
MED30MED2111480712584197 15989967 Affinity Capture-Western; Reconstituted Complex
MED30MED2112470712584197 15989967 Affinity Capture-Western; Reconstituted Complex
PPARGC1AMED2111480714636573 Affinity Capture-Western
PPARGC1AMED2111609714636573 Affinity Capture-Western
MED19MED2112855315175163 Affinity Capture-MS
MED19MED2111480715175163 Affinity Capture-MS
MED9MED2111480715175163 Affinity Capture-MS
MED9MED2112040315175163 Affinity Capture-MS
MED10MED2111480715175163 Affinity Capture-MS
MED10MED2112397415175163 Affinity Capture-MS
MED26MED2111480715175163 Affinity Capture-MS
MED26MED2111483115175163 Affinity Capture-MS
MED29MED2111480715175163 15989967 Affinity Capture-MS; Reconstituted Complex
MED29MED2112073415175163 15989967 Affinity Capture-MS; Reconstituted Complex
MED28MED2111480715175163 15989967 Affinity Capture-MS; Reconstituted Complex
MED28MED2112321915175163 15989967 Affinity Capture-MS; Reconstituted Complex
MED18MED2112015615989967 Reconstituted Complex
MED18MED2111480715989967 Reconstituted Complex
ZSCAN1MED2111480720211142 Two-hybrid
ZSCAN1MED2112982520211142 Two-hybrid
PCBD2MED2111480720211142 Two-hybrid
PCBD2MED2112389320211142 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1347064
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-2763'