AutismKB 2.0

Annotation Details for TNFRSF8


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Basic Information Top
Gene Symbol:TNFRSF8 ( CD30,D1S166E,Ki-1 )
Gene Full Name: tumor necrosis factor receptor superfamily, member 8
Band: 1p36.22
Quick LinksEntrez ID:943; OMIM: 153243; Uniprot ID:TNR8_HUMAN; ENSEMBL ID: ENSG00000120949; HGNC ID: 11923
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IBA-nucleus-
GO:0005737IEA-cytoplasm-
GO:0005886TAS-plasma membrane-
GO:0005887IBA-integral component of plasma membrane-
GO:0043005IBA-neuron projection-
GO:0070062IDA-extracellular exosome20458337
GO ID Evidence Qualifier GO_term References
GO:0004888TAS-transmembrane signaling receptor activity1310894
GO:0005031IBA-tumor necrosis factor-activated receptor activity-
GO:0048406IBA-nerve growth factor binding-
GO ID Evidence Qualifier GO_term References
GO:0006954IBA-inflammatory response-
GO:0006955IBA-immune response-
GO:0007165TAS-signal transduction10192335
GO:0007411IBA-axon guidance-
GO:0008285TAS-negative regulation of cell proliferation10192335
GO:0010977IBA-negative regulation of neuron projection development-
GO:0032496IBA-response to lipopolysaccharide-
GO:0033209TAS-tumor necrosis factor-mediated signaling pathway-
GO:0042535IDA-positive regulation of tumor necrosis factor biosynthetic process16108830
GO:0043065IDA-positive regulation of apoptotic process16108830
GO:0045556IDA-positive regulation of TRAIL biosynthetic process16108830
GO:0071260IEP-cellular response to mechanical stimulus19593445
GO:0097190IBA-apoptotic signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TRAF5TNFRSF81130408999898 Affinity Capture-Western; Reconstituted Complex
TRAF5TNFRSF81073818999898 Affinity Capture-Western; Reconstituted Complex
TRAF2TNFRSF81130388999898 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TRAF2TNFRSF81073818999898 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TRAIPTNFRSF81155819104814 Affinity Capture-Western
TRAIPTNFRSF81073819104814 Affinity Capture-Western
TDP2TNFRSF811961510764746 Affinity Capture-Western
TDP2TNFRSF810738110764746 Affinity Capture-Western
TNFSF8TNFRSF810738111754357 Reconstituted Complex
TNFSF8TNFRSF810738211754357 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
TNFRSF8hCV9567 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:99908
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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