AutismKB 2.0

Annotation Details for EIF2AK3


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Basic Information Top
Gene Symbol:EIF2AK3 ( DKFZp781H1925,PEK,PERK,WRS )
Gene Full Name: eukaryotic translation initiation factor 2-alpha kinase 3
Band: 2p11.2
Quick LinksEntrez ID:9451; OMIM: 604032; Uniprot ID:E2AK3_HUMAN; ENSEMBL ID: ENSG00000172071; HGNC ID: 3255
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737ISS-cytoplasm-
GO:0005783IC-endoplasmic reticulum11907036
GO:0005783ISS-endoplasmic reticulum-
GO:0005783TAS-endoplasmic reticulum12086964
GO:0005789ISS-endoplasmic reticulum membrane-
GO:0005789NAS-endoplasmic reticulum membrane11907036
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0016020IDA-membrane19946888
GO:0030176NAS-integral component of endoplasmic reticulum membrane22013210
GO:0048471IEA-perinuclear region of cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0004672TAS-protein kinase activity10026192
GO:0004674ISS-protein serine/threonine kinase activity-
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0004694IDA-eukaryotic translation initiation factor 2alpha kinase activity10026192
GO:0004694IMP-eukaryotic translation initiation factor 2alpha kinase activity12086964
GO:0005515IPI-protein binding11907036
GO:0005524IEA-ATP binding-
GO:0019899IPI-enzyme binding23103912
GO:0019903IPI-protein phosphatase binding22169477
GO:0042802IPI-identical protein binding11907036
GO:0042803TAS-protein homodimerization activity22934019
GO:0051879IEA-Hsp90 protein binding-
GO ID Evidence Qualifier GO_term References
GO:0001501ISS-skeletal system development-
GO:0001503IMP-ossification12086964
GO:0001525IMP-angiogenesis22915762
GO:0002063ISS-chondrocyte development-
GO:0006468ISS-protein phosphorylation-
GO:0006919ISS-activation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0006983IDA-ER overload response10677345
GO:0007029ISS-endoplasmic reticulum organization-
GO:0010575IMP-positive regulation of vascular endothelial growth factor production22915762
GO:0010628IMP-positive regulation of gene expression22915762
GO:0010998ISS-regulation of translational initiation by eIF2 alpha phosphorylation-
GO:0017148TAS-negative regulation of translation12086964
GO:0018105ISS-peptidyl-serine phosphorylation-
GO:0019722ISS-calcium-mediated signaling-
GO:0030073ISS-insulin secretion-
GO:0030282ISS-bone mineralization-
GO:0030968IDA-endoplasmic reticulum unfolded protein response10677345
GO:0030968TAS-endoplasmic reticulum unfolded protein response19816510
GO:0031018IMP-endocrine pancreas development12086964
GO:0031642ISS-negative regulation of myelination-
GO:0032057TAS-negative regulation of translational initiation in response to stress10677345
GO:0034198IMP-cellular response to amino acid starvation25329545
GO:0034976IMP-response to endoplasmic reticulum stress19061639
GO:0036492IMP-eiF2alpha phosphorylation in response to endoplasmic reticulum stress25329545
GO:0036492TAS-eiF2alpha phosphorylation in response to endoplasmic reticulum stress22934019
GO:0036499TAS-PERK-mediated unfolded protein response22934019
GO:0042149IMP-cellular response to glucose starvation22915762
GO:0045943IMP-positive regulation of transcription from RNA polymerase I promoter22915762
GO:0046777IDA-protein autophosphorylation10026192
GO:0046777IMP-protein autophosphorylation12086964
GO:0048009ISS-insulin-like growth factor receptor signaling pathway-
GO:0051260IMP-protein homooligomerization11907036
GO:0060734ISS-regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation-
GO:0070417IMP-cellular response to cold25329545
GO:1900182ISS-positive regulation of protein localization to nucleus-
GO:1902235IMP-regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway23000344
GO:1990737IEA-response to manganese-induced endoplasmic reticulum stress-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
EIF2AK3HSPA511484011907036 Affinity Capture-Western
EIF2AK3HSPA510954111907036 Affinity Capture-Western
EIF2AK3HSP90AA110955212446770 Affinity Capture-Western
EIF2AK3HSP90AA111484012446770 Affinity Capture-Western
EIF2AK3NFE2L211484014517290 Biochemical Activity; Two-hybrid
EIF2AK3NFE2L211085214517290 Biochemical Activity; Two-hybrid
EIF2AK3DNAJC311484012446838 Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex
EIF2AK3DNAJC311159712446838 Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex
EIF2AK3HSP90B111484011907036 Affinity Capture-Western
EIF2AK3HSP90B111303611907036 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1341830
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050414-2'