AutismKB 2.0

Annotation Details for PICK1


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Basic Information Top
Gene Symbol:PICK1 ( MGC15204,PICK,PRKCABP )
Gene Full Name: protein interacting with PRKCA 1
Band: 22q13.1
Quick LinksEntrez ID:9463; OMIM: 605926; Uniprot ID:PICK1_HUMAN; ENSEMBL ID: ENSG00000100151; HGNC ID: 9394
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm11343649
GO:0005739IDA-mitochondrion-
GO:0005794ISS-Golgi apparatus-
GO:0005829IDA-cytosol-
GO:0005856IEA-cytoskeleton-
GO:0005886IDA-plasma membrane11343649
GO:0005886TAS-plasma membrane-
GO:0014069IEA-postsynaptic density-
GO:0016235IDA-aggresome-
GO:0030054IEA-cell junction-
GO:0030666TAS-endocytic vesicle membrane-
GO:0042734IDA-presynaptic membrane11343649
GO:0043005ISS-neuron projection-
GO:0045202ISS-synapse-
GO:0045211IEA-postsynaptic membrane-
GO:0048471ISS-perinuclear region of cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0001664ISS-G-protein coupled receptor binding-
GO:0005080ISS-protein kinase C binding-
GO:0005102ISS-receptor binding-
GO:0005515IPI-protein binding11802773
GO:0008022IPI-protein C-terminus binding11343649
GO:0016887ISS-ATPase activity-
GO:0019899IPI-enzyme binding16314870
GO:0019904ISS-protein domain specific binding-
GO:0042802ISS-identical protein binding-
GO:0046872IEA-metal ion binding-
GO:0051015ISS-actin filament binding-
GO:0071933ISS-Arp2/3 complex binding-
GO ID Evidence Qualifier GO_term References
GO:0002092ISS-positive regulation of receptor internalization-
GO:0006468ISS-protein phosphorylation-
GO:0006890NAS-retrograde vesicle-mediated transport, Golgi to ER10623590
GO:0007205IDA-protein kinase C-activating G-protein coupled receptor signaling pathway10623590
GO:0015844IDA-monoamine transport11343649
GO:0021782ISS-glial cell development-
GO:0034315IBA-regulation of Arp2/3 complex-mediated actin nucleation-
GO:0034316ISS-negative regulation of Arp2/3 complex-mediated actin nucleation-
GO:0036294ISS-cellular response to decreased oxygen levels-
GO:0042149ISS-cellular response to glucose starvation-
GO:0043045NAS-DNA methylation involved in embryo development12138111
GO:0043046TAS-DNA methylation involved in gamete generation12138111
GO:0043113ISS-receptor clustering-
GO:0045161TAS-neuronal ion channel clustering11343649
GO:0060292ISS-long term synaptic depression-
GO:0097061ISS-dendritic spine organization-
GO:0097062ISS-dendritic spine maintenance-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PICK1ACCN210655911802773 12578970 Affinity Capture-Western; Two-hybrid
PICK1ACCN211484911802773 12578970 Affinity Capture-Western; Two-hybrid
PICK1BNC111484911802773 Affinity Capture-Western; Two-hybrid
PICK1BNC110711511802773 Affinity Capture-Western; Two-hybrid
PICK1ERBB211484911278603 Affinity Capture-Western; Two-hybrid
PICK1ERBB210837611278603 Affinity Capture-Western; Two-hybrid
PICK1PRLHR11484911641419 Affinity Capture-Western
PICK1PRLHR10909511641419 Affinity Capture-Western
PICK1GRIA111484911891216 Reconstituted Complex
PICK1GRIA110914711891216 Reconstituted Complex
PICK1GRIA211484911891216 Reconstituted Complex; Two-hybrid
PICK1GRIA210914811891216 Reconstituted Complex; Two-hybrid
PICK1GRIA311484911891216 Reconstituted Complex; Two-hybrid
PICK1GRIA310914911891216 Reconstituted Complex; Two-hybrid
PICK1GRIA411484911891216 Reconstituted Complex; Two-hybrid
PICK1GRIA410915011891216 Reconstituted Complex; Two-hybrid
PICK1GRIK111484912597860 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PICK1GRIK110915412597860 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PICK1GRIK210915512597860 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PICK1GRIK211484912597860 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PICK1GRIK310915611891216 Reconstituted Complex; Two-hybrid
PICK1GRIK311484911891216 Reconstituted Complex; Two-hybrid
PICK1GRM310917011891216 Reconstituted Complex; Two-hybrid
PICK1GRM311484911891216 Reconstituted Complex; Two-hybrid
PICK1GRM710917411007882 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
PICK1GRM711484911007882 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
PICK1PRKCA11484911007882 Affinity Capture-Western
PICK1PRKCA11156411007882 Affinity Capture-Western
PICK1SLC6A311242211343649 Affinity Capture-Western; Two-hybrid
PICK1SLC6A311484911343649 Affinity Capture-Western; Two-hybrid
ERBB2IPPICK112099711278603 Two-hybrid
ERBB2IPPICK111484911278603 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
PICK1rs2076369, rs3026685, rs3952, rs713729, rs737662, rs742396, rs760975 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:894645
  • Data Attributes: MGI curated and HomoloGene calculated
No data