AutismKB 2.0

Annotation Details for GDF15


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Basic Information Top
Gene Symbol:GDF15 ( GDF-15,MIC-1,MIC1,NAG-1,PDF,PLAB,PTGFB )
Gene Full Name: growth differentiation factor 15
Band: 19p13.11
Quick LinksEntrez ID:9518; OMIM: 605312; Uniprot ID:GDF15_HUMAN; ENSEMBL ID: ENSG00000130513; HGNC ID: 30142
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region9326641
GO:0005615IDA-extracellular space25893289
GO:0005634IDA-nucleus25893289
GO:0005737IDA-cytoplasm25893289
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0005125IBA-cytokine activity-
GO:0005160IBA-transforming growth factor beta receptor binding-
GO:0005515IPI-protein binding19060904
GO:0008083IEA-growth factor activity-
GO ID Evidence Qualifier GO_term References
GO:0007165TAS-signal transduction9326641
GO:0007179TAS-transforming growth factor beta receptor signaling pathway9348093
GO:0007267TAS-cell-cell signaling9326641
GO:0010862IBA-positive regulation of pathway-restricted SMAD protein phosphorylation-
GO:0030509IBA-BMP signaling pathway-
GO:0042981IBA-regulation of apoptotic process-
GO:0043408IBA-regulation of MAPK cascade-
GO:0048468IBA-cell development-
GO:0060395IDA-SMAD protein signal transduction25893289
GO:1901741IEA-positive regulation of myoblast fusion-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GDF15GDF151148959326641 10811612 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1346047
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018