AutismKB 2.0

Annotation Details for BAG4


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Basic Information Top
Gene Symbol:BAG4 ( BAG-4,SODD )
Gene Full Name: BCL2-associated athanogene 4
Band: 8p11.23
Quick LinksEntrez ID:9530; OMIM: 603884; Uniprot ID:BAG4_HUMAN; ENSEMBL ID: ENSG00000156735; HGNC ID: 940
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus21712384
GO:0005829IDA-cytosol21712384
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane21712384
GO ID Evidence Qualifier GO_term References
GO:0000774TAS-adenyl-nucleotide exchange factor activity-
GO:0003723IDA-RNA binding22681889
GO:0005057TAS-signal transducer activity, downstream of receptor9915703
GO:0005515IPI-protein binding25036637
GO:0031625IPI-ubiquitin protein ligase binding24270810
GO:0051087IEA-chaperone binding-
GO ID Evidence Qualifier GO_term References
GO:0006457TAS-protein folding9873016
GO:0010763IEA-positive regulation of fibroblast migration-
GO:0030838IEA-positive regulation of actin filament polymerization-
GO:0033138IEA-positive regulation of peptidyl-serine phosphorylation-
GO:0033209TAS-tumor necrosis factor-mediated signaling pathway-
GO:0043066TAS-negative regulation of apoptotic process9915703
GO:0045785IEA-positive regulation of cell adhesion-
GO:0051291IEA-protein heterooligomerization-
GO:0051496IEA-positive regulation of stress fiber assembly-
GO:0051897IEA-positive regulation of protein kinase B signaling-
GO:0071356IDA-cellular response to tumor necrosis factor21712384
GO:0071364IEA-cellular response to epidermal growth factor stimulus-
GO:0072659IEA-protein localization to plasma membrane-
GO:0090367IEA-negative regulation of mRNA modification-
GO:0097178IEA-ruffle assembly-
GO:1900034TAS-regulation of cellular response to heat-
GO:1903215IMP-negative regulation of protein targeting to mitochondrion24270810
GO:2001145IEA-negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
BAG4APOBEC111490614559896 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BAG4APOBEC110683614559896 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BAG4HSPA411490614559896 Affinity Capture-Western
BAG4HSPA410954014559896 Affinity Capture-Western
BAG4HSPA811490611909948 Reconstituted Complex
BAG4HSPA810954411909948 Reconstituted Complex
BAG4HSP90AA111490614559896 Affinity Capture-Western
BAG4HSP90AA110955214559896 Affinity Capture-Western
BAG4TNFRSF1A1129869915703 11909948 Affinity Capture-Western; Reconstituted Complex
BAG4TNFRSF1A1149069915703 11909948 Affinity Capture-Western; Reconstituted Complex
BAG4TNFRSF251142589915703 Affinity Capture-Western
BAG4TNFRSF251149069915703 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
BAG4BCL225942211527400 Bcl-2 interacts with BAG-4. This interaction was modelled on a demonstrated interaction between Bcl-2 from an unspecified species and human BAG-4.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1914634
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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