AutismKB 2.0

Annotation Details for BAG3


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Basic Information Top
Gene Symbol:BAG3 ( BAG-3,BIS,CAIR-1,MGC104307 )
Gene Full Name: BCL2-associated athanogene 3
Band: 10q26.11
Quick LinksEntrez ID:9531; OMIM: 603883; Uniprot ID:BAG3_HUMAN; ENSEMBL ID: ENSG00000151929; HGNC ID: 939
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus26159920
GO:0005737IDA-cytoplasm26159920
GO:0005829IDA-cytosol10597216
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane-
GO:0030018IEA-Z disc-
GO:0043005IEA-neuron projection-
GO ID Evidence Qualifier GO_term References
GO:0000774IDA-adenyl-nucleotide exchange factor activity20060297
GO:0000774TAS-adenyl-nucleotide exchange factor activity-
GO:0005515IPI-protein binding16189514
GO:0032403IEA-protein complex binding-
GO:0045296IDA-cadherin binding25468996
GO:0051087IEA-chaperone binding-
GO ID Evidence Qualifier GO_term References
GO:0006457NAS-protein folding9873016
GO:0007420IEA-brain development-
GO:0008625IDA-extrinsic apoptotic signaling pathway via death domain receptors10597216
GO:0010664IEA-negative regulation of striated muscle cell apoptotic process-
GO:0021510IEA-spinal cord development-
GO:0034605IDA-cellular response to heat26159920
GO:0042993IMP-positive regulation of transcription factor import into nucleus26159920
GO:0043066NAS-negative regulation of apoptotic process10597216
GO:0046827IMP-positive regulation of protein export from nucleus26159920
GO:0050790IEA-regulation of catalytic activity-
GO:0050821IEA-protein stabilization-
GO:0071260IEA-cellular response to mechanical stimulus-
GO:0097192IEA-extrinsic apoptotic signaling pathway in absence of ligand-
GO:0097201IMP-negative regulation of transcription from RNA polymerase II promoter in response to stress26159920
GO:1900034TAS-regulation of cellular response to heat-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
BAG3DVL211490716189514 Two-hybrid
BAG3DVL210818916189514 Two-hybrid
BAG3HSPA1A10953510980614 11527400 Affinity Capture-Western
BAG3HSPA1A11490710980614 11527400 Affinity Capture-Western
BAG3HSPA411490712750378 Affinity Capture-Western; Reconstituted Complex
BAG3HSPA410954012750378 Affinity Capture-Western; Reconstituted Complex
BAG3HSPA81149079873016 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BAG3HSPA81095449873016 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BAG3PLCG111490710980614 Affinity Capture-Western; Reconstituted Complex
BAG3PLCG111135110980614 Affinity Capture-Western; Reconstituted Complex
BAG3FAM189A211480816189514 Two-hybrid
BAG3FAM189A211490716189514 Two-hybrid
HSPB8BAG311490716189514 Two-hybrid
HSPB8BAG311768916189514 Two-hybrid
DAZAP2BAG311490716189514 Two-hybrid
DAZAP2BAG311514316189514 Two-hybrid
AMOTBAG311490719615732 Affinity Capture-MS
AMOTBAG312755719615732 Affinity Capture-MS
WNK1BAG311490720936779 Two-hybrid
WNK1BAG312240320936779 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
BAG3BCL225942111527400 Bcl-2 interacts with BAG-3. This interaction was modelled on a demonstrated interaction between Bcl-2 from an unspecified species and human BAG-3.
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
BAG3rs196295, rs2234962 Gene overview in AlzGene
No data
Gene Symbol Poly Names Gene overview in SZGene
BAG3rs196290 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1352493
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040801-40'