AutismKB 2.0

Annotation Details for NRG2


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Basic Information Top
Gene Symbol:NRG2 ( DON1,HRG2,NTAK )
Gene Full Name: neuregulin 2
Band: 5q31.2
Quick LinksEntrez ID:9542; OMIM: 603818; Uniprot ID:NRG2_HUMAN; ENSEMBL ID: ENSG00000158458; HGNC ID: 7998
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005622IEA-intracellular-
GO:0005886IEA-plasma membrane-
GO:0016021IEA-integral component of membrane-
GO ID Evidence Qualifier GO_term References
GO:0004713TAS-protein tyrosine kinase activity-
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005102TAS-receptor binding9168114
GO:0008083IEA-growth factor activity-
GO:0046934TAS-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0007165TAS-signal transduction9168114
GO:0014066TAS-regulation of phosphatidylinositol 3-kinase signaling-
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0038128TAS-ERBB2 signaling pathway-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0046854IEA-phosphatidylinositol phosphorylation-
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:1901185TAS-negative regulation of ERBB signaling pathway-
GO:2000145TAS-regulation of cell motility-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NRG2ERBB31149179168115 Reconstituted Complex
NRG2ERBB31083779168115 Reconstituted Complex
NRG2ERBB41149179168115 Reconstituted Complex
NRG2ERBB41083789168115 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
NRG2rs1345708, rs1422717, rs1433302, rs1800954, rs2436387, rs2436589, rs265150, rs265158, rs2916093, rs2936651, rs3756675, rs3777102, rs3863190, rs443587, rs6580323, rs6864507, rs6870884, rs6885391, rs7700260, rs7734418 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1098246
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070615-10'