AutismKB 2.0

Annotation Details for H2AFY


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Basic Information Top
Gene Symbol:H2AFY ( H2A.y,H2A/y,H2AF12M,H2AFJ,MACROH2A1.1,mH2A1,macroH2A1.2 )
Gene Full Name: H2A histone family, member Y
Band: 5q31.1
Quick LinksEntrez ID:9555; OMIM: 610054; Uniprot ID:H2AY_HUMAN; ENSEMBL ID: ENSG00000113648; HGNC ID: 4740
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000228IDA-nuclear chromosome18936163
GO:0000784IDA-nuclear chromosome, telomeric region19135898
GO:0000786NAS-nucleosome9714746
GO:0000790IDA-nuclear chromatin19734898
GO:0000793IEA-condensed chromosome-
GO:0001739TAS-sex chromatin19486527
GO:0001740IDA-Barr body11331621
GO:0005634IDA-nucleus21630459
GO:0005721IDA-pericentric heterochromatin19486527
GO:0005730IDA-nucleolus24071584
GO:0035098IDAcolocalizes_withESC/E(Z) complex19734898
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0000182IDA-rDNA binding24071584
GO:0000977IDA-RNA polymerase II regulatory region sequence-specific DNA binding23595991
GO:0000979IDA-RNA polymerase II core promoter sequence-specific DNA binding25526730
GO:0001046ISS-core promoter sequence-specific DNA binding-
GO:0003677NAS-DNA binding9714746
GO:0005515IPI-protein binding22391447
GO:0010385IDA-double-stranded methylated DNA binding24071584
GO:0019899IPI-enzyme binding26373281
GO:0019901IPI-protein kinase binding22194607
GO:0030291IMP-protein serine/threonine kinase inhibitor activity22194607
GO:0031490IDA-chromatin DNA binding19734898
GO:0031492IDA-nucleosomal DNA binding20008927
GO:0031492ISS-nucleosomal DNA binding-
GO:0044212IDA-transcription regulatory region DNA binding19734898
GO:0046982IEA-protein heterodimerization activity-
GO ID Evidence Qualifier GO_term References
GO:0000122IMP-negative regulation of transcription from RNA polymerase II promoter19734898
GO:0001558IGINOTregulation of cell growth24071584
GO:0006334NAS-nucleosome assembly9714746
GO:0006342IBA-chromatin silencing-
GO:0007549IDA-dosage compensation15053874
GO:0016569IEA-covalent chromatin modification-
GO:0019216IMP-regulation of lipid metabolic process25526730
GO:0033128IMP-negative regulation of histone phosphorylation22194607
GO:0034184IDA-positive regulation of maintenance of mitotic sister chromatid cohesion26373281
GO:0040029IMP-regulation of gene expression, epigenetic20008927
GO:0045618IMP-positive regulation of keratinocyte differentiation23595991
GO:0045814IMP-negative regulation of gene expression, epigenetic19734898
GO:0045815IMP-positive regulation of gene expression, epigenetic25526730
GO:0051572IMP-negative regulation of histone H3-K4 methylation25526730
GO:0061086IMP-negative regulation of histone H3-K27 methylation25526730
GO:0061187IMPNOTregulation of chromatin silencing at rDNA24071584
GO:0071169IMP-establishment of protein localization to chromatin19734898
GO:0071901IMP-negative regulation of protein serine/threonine kinase activity22194607
GO:1901837IGI-negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter24071584
GO:1901837IMP-negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter24071584
GO:1902750IMP-negative regulation of cell cycle G2/M phase transition22194607
GO:1902882IMP-regulation of response to oxidative stress23022728
GO:1904815IDA-negative regulation of protein localization to chromosome, telomeric region26373281
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
H2AFYPARP111492717158748 17322296 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
H2AFYPARP110665217158748 17322296 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
H2AFYBRCA111492712419249 Co-localization
H2AFYBRCA110714012419249 Co-localization
H2AFYCENPA11492715009096 Co-purification
H2AFYCENPA10748715009096 Co-purification
H2AFYRCC111492717158748 Affinity Capture-MS
H2AFYRCC110752917158748 Affinity Capture-MS
H2AFYHDAC111492717158748 Affinity Capture-MS
H2AFYHDAC110931517158748 Affinity Capture-MS
H2AFYHSPA411492717158748 Affinity Capture-MS
H2AFYHSPA410954017158748 Affinity Capture-MS
H2AFYRAN11492717158748 Affinity Capture-MS
H2AFYRAN11183717158748 Affinity Capture-MS
H2AFYTOP111492717158748 Affinity Capture-MS
H2AFYTOP111300317158748 Affinity Capture-MS
H2AFYXRCC511492717158748 Affinity Capture-MS
H2AFYXRCC511335317158748 Affinity Capture-MS
H2AFYDEK11492717158748 Affinity Capture-MS
H2AFYDEK11364317158748 Affinity Capture-MS
H2AFYCUL311492715897469 Affinity Capture-Western
H2AFYCUL311403015897469 Affinity Capture-Western
WDR77H2AFY11492717158748 Affinity Capture-MS
WDR77H2AFY12253217158748 Affinity Capture-MS
PHF14H2AFY11503217158748 Affinity Capture-MS
PHF14H2AFY11492717158748 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1349392
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-060421-4796'