Gene Symbol:	CLOCK ( KAT13D,KIAA0334,bHLHe8 )
Gene Full Name:	clock homolog (mouse)
Band:	4q12
Quick Links	Entrez ID:9575; OMIM: 601851; Uniprot ID:CLOCK_HUMAN; ENSEMBL ID: ENSG00000134852; HGNC ID: 2082
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005634	IDA	-	nucleus	14645221
GO:0005654	IDA	-	nucleoplasm	-
GO:0005654	TAS	-	nucleoplasm	-
GO:0005667	IPI	-	transcription factor complex	9576906
GO:0005694	IDA	-	chromosome	21659603
GO:0033391	ISS	-	chromatoid body	-
GO:0043231	IDA	-	intracellular membrane-bounded organelle	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0000978	IDA	-	RNA polymerase II core promoter proximal region sequence-specific DNA binding	18411297
GO:0000982	ISS	-	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding	-
GO:0001046	IEA	-	core promoter sequence-specific DNA binding	-
GO:0001047	ISS	-	core promoter binding	-
GO:0001190	ISS	-	transcriptional activator activity, RNA polymerase II transcription factor binding	-
GO:0003677	IDA	-	DNA binding	11441146
GO:0003700	ISS	-	transcription factor activity, sequence-specific DNA binding	-
GO:0004402	IMP	-	histone acetyltransferase activity	21980503
GO:0005515	IPI	-	protein binding	14645221
GO:0031490	ISS	-	chromatin DNA binding	-
GO:0043565	ISS	-	sequence-specific DNA binding	-
GO:0046983	IEA	-	protein dimerization activity	-
GO:0070888	IDA	-	E-box binding	18411297

GO ID	Evidence	Qualifier	GO_term	References
GO:0000077	IMP	-	DNA damage checkpoint	21659603
GO:0006355	ISS	-	regulation of transcription, DNA-templated	-
GO:0006357	TAS	-	regulation of transcription from RNA polymerase II promoter	10198158
GO:0006366	IEA	-	transcription from RNA polymerase II promoter	-
GO:0007165	TAS	-	signal transduction	10198158
GO:0007283	ISS	-	spermatogenesis	-
GO:0007623	TAS	-	circadian rhythm	-
GO:0009648	TAS	-	photoperiodism	10198158
GO:0016573	IEA	-	histone acetylation	-
GO:0032922	IDA	-	circadian regulation of gene expression	24005054
GO:0032922	IMP	-	circadian regulation of gene expression	21980503
GO:0032922	ISS	-	circadian regulation of gene expression	-
GO:0042634	IMP	-	regulation of hair cycle	24005054
GO:0043161	ISS	-	proteasome-mediated ubiquitin-dependent protein catabolic process	-
GO:0045892	ISS	-	negative regulation of transcription, DNA-templated	-
GO:0045893	IDA	-	positive regulation of transcription, DNA-templated	23785138
GO:0045893	ISS	-	positive regulation of transcription, DNA-templated	-
GO:0045944	IGI	-	positive regulation of transcription from RNA polymerase II promoter	9576906
GO:0050729	IEA	-	positive regulation of inflammatory response	-
GO:0050796	ISS	-	regulation of insulin secretion	-
GO:0051092	ISS	-	positive regulation of NF-kappaB transcription factor activity	-
GO:0051775	IDA	-	response to redox state	11441146
GO:0071479	IDA	-	cellular response to ionizing radiation	21659603
GO:2000074	ISS	-	regulation of type B pancreatic cell development	-
GO:2000323	ISS	-	negative regulation of glucocorticoid receptor signaling pathway	-

Gene Symbol	Interactant	Interaction ID	References	Description
CLOCK	ARNTL	106899	9576906 11439184 14701734	Two-hybrid
CLOCK	ARNTL	114944	9576906 11439184 14701734	Two-hybrid
CLOCK	EP300	108347	14645221	Reconstituted Complex
CLOCK	EP300	114944	14645221	Reconstituted Complex
CLOCK	RARA	114944	11439184	Reconstituted Complex; Two-hybrid
CLOCK	RARA	111849	11439184	Reconstituted Complex; Two-hybrid
CLOCK	RXRA	114944	11439184	Reconstituted Complex; Two-hybrid
CLOCK	RXRA	112168	11439184	Reconstituted Complex; Two-hybrid
CLOCK	KAT2B	114375	14645221	Reconstituted Complex
CLOCK	KAT2B	114944	14645221	Reconstituted Complex
ARNTL2	CLOCK	121263	14701734	Two-hybrid
ARNTL2	CLOCK	114944	14701734	Two-hybrid
SIRT1	CLOCK	116983	18662547	Affinity Capture-Western; Reconstituted Complex
SIRT1	CLOCK	114944	18662547	Affinity Capture-Western; Reconstituted Complex

AutismKB 2.0

Annotation Details for CLOCK