AutismKB 2.0

Annotation Details for CD44


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Basic Information Top
Gene Symbol:CD44 ( CDW44,CSPG8,ECMR-III,HCELL,HUTCH-I,IN,LHR,MC56,MDU2,MDU3,MGC10468,MIC4,Pgp1 )
Gene Full Name: CD44 molecule (Indian blood group)
Band: 11p13
Quick LinksEntrez ID:960; OMIM: 107269; Uniprot ID:CD44_HUMAN; ENSEMBL ID: ENSG00000026508; HGNC ID: 1681
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005794IDA-Golgi apparatus-
GO:0005829IDA-cytosol-
GO:0005886IDA-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005887NAS-integral component of plasma membrane1991450
GO:0005925IDA-focal adhesion21423176
GO:0009986IDA-cell surface16809613
GO:0030667TAS-secretory granule membrane-
GO:0035692IDA-macrophage migration inhibitory factor receptor complex17045821
GO:0070062IDA-extracellular exosome19199708
GO ID Evidence Qualifier GO_term References
GO:0004896IDAcontributes_tocytokine receptor activity17045821
GO:0005515IPI-protein binding11207560
GO:0005518NAS-collagen binding2471973
GO:0005540IDA-hyaluronic acid binding17170110
GO:0005540NAS-hyaluronic acid binding1991450
GO ID Evidence Qualifier GO_term References
GO:0007160NAS-cell-matrix adhesion1922057
GO:0016337NAS-single organismal cell-cell adhesion1922057
GO:0022617TAS-extracellular matrix disassembly-
GO:0030198TAS-extracellular matrix organization-
GO:0030214IDA-hyaluronan catabolic process17170110
GO:0030214TAS-hyaluronan catabolic process-
GO:0033138IDA-positive regulation of peptidyl-serine phosphorylation17045821
GO:0034116IMP-positive regulation of heterotypic cell-cell adhesion15100360
GO:0043066IMP-negative regulation of apoptotic process19047049
GO:0043154IMP-negative regulation of cysteine-type endopeptidase activity involved in apoptotic process19047049
GO:0043312TAS-neutrophil degranulation-
GO:0043518IDA-negative regulation of DNA damage response, signal transduction by p53 class mediator17045821
GO:0044344IDA-cellular response to fibroblast growth factor stimulus19577615
GO:0050731IDA-positive regulation of peptidyl-tyrosine phosphorylation17045821
GO:0050900TAS-leukocyte migration-
GO:0051216IEP-cartilage development11944887
GO:0060333TAS-interferon-gamma-mediated signaling pathway-
GO:0070374IDA-positive regulation of ERK1 and ERK2 cascade17045821
GO:0070487IMP-monocyte aggregation15100360
GO:1900625IMP-positive regulation of monocyte aggregation20522558
GO:1902166IDA-negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator17045821
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FN1CD441073981730778 Affinity Capture-Western; Reconstituted Complex
FN1CD441086211730778 Affinity Capture-Western; Reconstituted Complex
HBEGFCD441073987532176 Reconstituted Complex
HBEGFCD441081727532176 Reconstituted Complex
LCKCD441101248576267 9573028 Affinity Capture-Western; Co-fractionation
LCKCD441073988576267 9573028 Affinity Capture-Western; Co-fractionation
COL14A1CD441073988986622 Co-purification
COL14A1CD441132198986622 Co-purification
MSNCD441073989472040 Reconstituted Complex
MSNCD441105849472040 Reconstituted Complex
FYNCD441073989573028 Affinity Capture-Western; Co-fractionation
FYNCD441088109573028 Affinity Capture-Western; Co-fractionation
PTPRCCD441117529573028 Co-fractionation
PTPRCCD441073989573028 Co-fractionation
TIAM1CD4410739810636882 Reconstituted Complex
TIAM1CD4411293010636882 Reconstituted Complex
VCANCD4410739810950950 Reconstituted Complex
VCANCD4410784410950950 Reconstituted Complex
SRCCD4411259211084024 Affinity Capture-Western; Reconstituted Complex
SRCCD4410739811084024 Affinity Capture-Western; Reconstituted Complex
VAV2CD4411325311606575 Affinity Capture-Western
VAV2CD4410739811606575 Affinity Capture-Western
ERBB4CD4410739811825873 Affinity Capture-Western
ERBB4CD4410837811825873 Affinity Capture-Western
MMP7CD4411045911825873 Affinity Capture-Western
MMP7CD4410739811825873 Affinity Capture-Western
EZRCD4411327112032545 Reconstituted Complex
EZRCD4410739812032545 Reconstituted Complex
EGFRCD4410739812093135 Affinity Capture-Western
EGFRCD4410827612093135 Affinity Capture-Western
ERBB2CD4410739812093135 Affinity Capture-Western
ERBB2CD4410837612093135 Affinity Capture-Western
IGFBP3CD4410970712127836 Reconstituted Complex
IGFBP3CD4410739812127836 Reconstituted Complex
TGFBR1CD4410739812145287 Reconstituted Complex
TGFBR1CD4411290412145287 Reconstituted Complex
ARHGEF1CD4411458512748184 Affinity Capture-Western
ARHGEF1CD4410739812748184 Affinity Capture-Western
NF2CD4411084417891137 Affinity Capture-Western
NF2CD4410739817891137 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
EPB41L3CD4421773315688033 EPB41L3 (DAL-1) interacts with an unspecified isoform of CD44.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:88338
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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