AutismKB 2.0

Annotation Details for SNCAIP


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Basic Information Top
Gene Symbol:SNCAIP ( MGC39814,SYPH1,Sph1 )
Gene Full Name: synuclein, alpha interacting protein
Band: 5q23.2
Quick LinksEntrez ID:9627; OMIM: 603779; Uniprot ID:SNCAP_HUMAN; ENSEMBL ID: ENSG00000064692; HGNC ID: 11139
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000932IDA-P-body-
GO:0005654IDA-nucleoplasm-
GO:0005737IDA-cytoplasm14506261
GO:0005829TAS-cytosol-
GO:0008021TAS-synaptic vesicle21563316
GO:0042734NAS-presynaptic membrane11956199
GO:0043025NAS-neuronal cell body11956199
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding10319874
GO:0031625IPI-ubiquitin protein ligase binding15728840
GO:0042802IPI-identical protein binding19762560
GO ID Evidence Qualifier GO_term References
GO:0008219IDA-cell death16595633
GO:0042417IDA-dopamine metabolic process14506261
GO:0044267TAS-cellular protein metabolic process-
GO:0046928IDA-regulation of neurotransmitter secretion14506261
GO:0090083IDA-regulation of inclusion body assembly15603737
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SNCAIPGSK3B11498616174773 Affinity Capture-Western; Biochemical Activity
SNCAIPGSK3B10918716174773 Affinity Capture-Western; Biochemical Activity
SNCAIPPARK211110511590439 15944382 16049031 Affinity Capture-Western; Biochemical Activity
SNCAIPPARK211498611590439 15944382 16049031 Affinity Capture-Western; Biochemical Activity
SNCAIPPTN11498616169070 Two-hybrid
SNCAIPPTN11173116169070 Two-hybrid
SNCAIPSIAH111498614506261 15064394 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
SNCAIPSIAH111237214506261 15064394 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
SNCAIPSIAH211498616174773 Biochemical Activity
SNCAIPSIAH211237316174773 Biochemical Activity
SNCAIPSNCA11250610319874 11331421 11742726 12044636 15944382 19762560 Affinity Capture-Western; Co-crystal Structure; FRET; Reconstituted Complex; Two-hybrid
SNCAIPSNCA11498610319874 11331421 11742726 12044636 15944382 19762560 Affinity Capture-Western; Co-crystal Structure; FRET; Reconstituted Complex; Two-hybrid
SNCAIPUBC11498612750386 14506261 15064394 15728840 15944382 16049031 Affinity Capture-Western
SNCAIPUBC11316412750386 14506261 15064394 15728840 15944382 16049031 Affinity Capture-Western
RNF19ASNCAIP11498612750386 Affinity Capture-Western
RNF19ASNCAIP11740512750386 Affinity Capture-Western
SH2D3CSNCAIP11498616169070 Two-hybrid
SH2D3CSNCAIP11535516169070 Two-hybrid
GET4SNCAIP11498616169070 Two-hybrid
GET4SNCAIP11963616169070 Two-hybrid
SNCAIPSNCAIP11498619762560 Reconstituted Complex
Gene Symbol Interactant Interaction ID References Description
SNCAIPPARK219632215603737 Synphilin interacts with parkin.
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
SNCAIPSNCAIP_1i, SNCAIP_4i, SNCAIP_6i Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
SNCAIPD5S2010, D5S2115, D5S2116, D5S2950, D5S414, D5S816, SNCAIP_Intron 4, SNCAIP_Intron-1, SNCAIP_Intron-4, SNCAIP_Intron-6, rs1946649, rs2061767, rs2242223, rs2242224, rs2290987, rs2290988, rs28937592, rs304383, rs6875859 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:1915097
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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