AutismKB 2.0

Annotation Details for KDM4A


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:KDM4A ( JHDM3A,JMJD2,JMJD2A,KIAA0677 )
Gene Full Name: lysine (K)-specific demethylase 4A
Band: 1p34.2-p34.1
Quick LinksEntrez ID:9682; OMIM: 609764; Uniprot ID:KDM4A_HUMAN; ENSEMBL ID: ENSG00000066135; HGNC ID: 22978
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001650IDA-fibrillar center-
GO:0005634IDA-nucleus16024779
GO:0005634IMP-nucleus21914792
GO:0005654TAS-nucleoplasm-
GO:0005721IEA-pericentric heterochromatin-
GO:0005829IDA-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding16415788
GO:0031625IPI-ubiquitin protein ligase binding22373579
GO:0032452TAS-histone demethylase activity-
GO:0032454IMP-histone demethylase activity (H3-K9 specific)21914792
GO:0035064IDA-methylated histone binding22373579
GO:0046872IEA-metal ion binding-
GO:0051864IDA-histone demethylase activity (H3-K36 specific)16024779
GO ID Evidence Qualifier GO_term References
GO:0006351IEA-transcription, DNA-templated-
GO:0010507IMP-negative regulation of autophagy25660547
GO:0010628IEA-positive regulation of gene expression-
GO:0010629IMP-negative regulation of gene expression25660547
GO:0014898IEA-cardiac muscle hypertrophy in response to stress-
GO:0016032IEA-viral process-
GO:0016577IDA-histone demethylation16024779
GO:0031667IEA-response to nutrient levels-
GO:0033169IMP-histone H3-K9 demethylation21914792
GO:0045666IEA-positive regulation of neuron differentiation-
GO:0045892IDA-negative regulation of transcription, DNA-templated16024779
GO:0048712IEA-negative regulation of astrocyte differentiation-
GO:0055114IEA-oxidation-reduction process-
GO:0060548IEA-negative regulation of cell death-
GO:0070544IDA-histone H3-K36 demethylation21914792
GO:1900113IEA-negative regulation of histone H3-K9 trimethylation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
KDM4AHDAC111503515927959 Affinity Capture-Western
KDM4AHDAC110931515927959 Affinity Capture-Western
KDM4ARB111503515927959 Affinity Capture-Western; Two-hybrid
KDM4ARB111186015927959 Affinity Capture-Western; Two-hybrid
KDM4AHIST1H3A11394616601153 16732292 Biochemical Activity; Co-crystal Structure; Protein-peptide
KDM4AHIST1H3A11503516601153 16732292 Biochemical Activity; Co-crystal Structure; Protein-peptide
KDM4AHDAC311503515927959 Affinity Capture-Western
KDM4AHDAC311436815927959 Affinity Capture-Western
KDM4ANCOR111503514527417 16024779 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-localization; Reconstituted Complex
KDM4ANCOR111497314527417 16024779 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-localization; Reconstituted Complex
KDM4CKDM4A11503517207460 Affinity Capture-Western
KDM4CKDM4A11671217207460 Affinity Capture-Western
KDM4AKDM4A11503517207460 Affinity Capture-Western
WDR48KDM4A11503519615732 Affinity Capture-MS
WDR48KDM4A12164919615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
KDM4Ars613976 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:2446210
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved