AutismKB 2.0

Annotation Details for RAPGEF2


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Basic Information Top
Gene Symbol:RAPGEF2 ( CNrasGEF,NRAPGEP,PDZ-GEF1,PDZGEF1,RA-GEF,Rap-GEP,nRap GEP )
Gene Full Name: Rap guanine nucleotide exchange factor (GEF) 2
Band: 4q32.1
Quick LinksEntrez ID:9693; OMIM: 609530; Uniprot ID:RPGF2_HUMAN; ENSEMBL ID: ENSG00000109756; HGNC ID: 16854
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm11359771
GO:0005770IDA-late endosome17724123
GO:0005829IDA-cytosol22797597
GO:0005829TAS-cytosol-
GO:0005886ISS-plasma membrane-
GO:0005887NAS-integral component of plasma membrane10934204
GO:0005911ISS-cell-cell junction-
GO:0005923IDA-bicellular tight junction23885123
GO:0016020IDA-membrane10608883
GO:0016324IDA-apical plasma membrane22797597
GO:0030139IDA-endocytic vesicle22797597
GO:0043005ISS-neuron projection-
GO:0043025ISS-neuronal cell body-
GO:0043234ISS-protein complex-
GO:0045202ISS-synapse-
GO:0048471IDA-perinuclear region of cytoplasm11359771
GO ID Evidence Qualifier GO_term References
GO:0004871TAS-signal transducer activity10934204
GO:0005088IDA-Ras guanyl-nucleotide exchange factor activity10801446
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005096IDA-GTPase activator activity10934204
GO:0005509NAS-calcium ion binding10934204
GO:0005515IPI-protein binding10548487
GO:0017034IDA-Rap guanyl-nucleotide exchange factor activity10548487
GO:0017034IMP-Rap guanyl-nucleotide exchange factor activity21840392
GO:0019992NAS-diacylglycerol binding10934204
GO:0030165IDA-PDZ domain binding10548487
GO:0030552IDA-cAMP binding10801446
GO:0030552IDANOTcAMP binding10548487
GO:0030553IDANOTcGMP binding10608844
GO:0031697IDA-beta-1 adrenergic receptor binding12391161
GO:0050699IDA-WW domain binding10548487
GO:0070300IDA-phosphatidic acid binding22797597
GO ID Evidence Qualifier GO_term References
GO:0000165NAS-MAPK cascade10934204
GO:0000165TAS-MAPK cascade-
GO:0001568ISS-blood vessel development-
GO:0001764ISS-neuron migration-
GO:0007186IDA-G-protein coupled receptor signaling pathway23800469
GO:0007218IDA-neuropeptide signaling pathway23800469
GO:0007264TAS-small GTPase mediated signal transduction10608883
GO:0008285IDA-negative regulation of cell proliferation16272156
GO:0010976ISS-positive regulation of neuron projection development-
GO:0019933IDA-cAMP-mediated signaling23800469
GO:0019933NAS-cAMP-mediated signaling10934204
GO:0021591ISS-ventricular system development-
GO:0021884ISS-forebrain neuron development-
GO:0030033IGI-microvillus assembly22797597
GO:0031175IDA-neuron projection development23800469
GO:0031547ISS-brain-derived neurotrophic factor receptor signaling pathway-
GO:0032092ISS-positive regulation of protein binding-
GO:0032486IMP-Rap protein signal transduction21840392
GO:0035556TAS-intracellular signal transduction10608883
GO:0038180ISS-nerve growth factor signaling pathway-
GO:0043547IDA-positive regulation of GTPase activity10548487
GO:0043547IMP-positive regulation of GTPase activity21840392
GO:0043950IDA-positive regulation of cAMP-mediated signaling12391161
GO:0045860IDA-positive regulation of protein kinase activity11359771
GO:0048022ISS-negative regulation of melanin biosynthetic process-
GO:0048167ISS-regulation of synaptic plasticity-
GO:0050774IDA-negative regulation of dendrite morphogenesis16272156
GO:0061028IMP-establishment of endothelial barrier21840392
GO:0070374IDA-positive regulation of ERK1 and ERK2 cascade16272156
GO:0071320IDA-cellular response to cAMP10801446
GO:0071321IDA-cellular response to cGMP10801446
GO:0071880IDA-adenylate cyclase-activating adrenergic receptor signaling pathway12391161
GO:0072659IMP-protein localization to plasma membrane22797597
GO:0090557IMP-establishment of endothelial intestinal barrier23885123
GO:1901888IMP-regulation of cell junction assembly21840392
GO:1990090ISS-cellular response to nerve growth factor stimulus-
GO:2000481IDA-positive regulation of cAMP-dependent protein kinase activity16272156
GO:2000670IDA-positive regulation of dendritic cell apoptotic process16272156
GO:2001214ISS-positive regulation of vasculogenesis-
GO:2001224ISS-positive regulation of neuron migration-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RAPGEF2HSPA1A10953520936779 Two-hybrid
RAPGEF2HSPA1A11504520936779 Two-hybrid
RAPGEF2KIF5A11504520936779 Two-hybrid
RAPGEF2KIF5A10999920936779 Two-hybrid
RAPGEF2KIF5B11000020936779 Two-hybrid
RAPGEF2KIF5B11504520936779 Two-hybrid
RAPGEF2ATP811504520936779 Two-hybrid
RAPGEF2ATP811061320936779 Two-hybrid
RAPGEF2RALGDS1150457809086 Reconstituted Complex; Two-hybrid
RAPGEF2RALGDS1118367809086 Reconstituted Complex; Two-hybrid
RAPGEF2RAP1A11504510934204 Biochemical Activity; Reconstituted Complex
RAPGEF2RAP1A11184110934204 Biochemical Activity; Reconstituted Complex
RAPGEF2RAP2B11184710934204 Reconstituted Complex
RAPGEF2RAP2B11504510934204 Reconstituted Complex
MOBKL3RAPGEF211504520936779 Two-hybrid
MOBKL3RAPGEF211736920936779 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2659071
  • Data Attributes: MGI curated and HomoloGene calculated
No data