AutismKB 2.0

Annotation Details for EDEM1


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Basic Information Top
Gene Symbol:EDEM1 ( EDEM,FLJ51559,FLJ51560,KIAA0212 )
Gene Full Name: ER degradation enhancer, mannosidase alpha-like 1
Band: 3p26.1
Quick LinksEntrez ID:9695; OMIM: 607673; Uniprot ID:EDEM1_HUMAN; ENSEMBL ID: ENSG00000134109; HGNC ID: 18967
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139IBA-Golgi membrane-
GO:0005783IDA-endoplasmic reticulum24200403
GO:0005783IMP-endoplasmic reticulum21062743
GO:0030176ISS-integral component of endoplasmic reticulum membrane-
GO:0044322TAS-endoplasmic reticulum quality control compartment-
GO ID Evidence Qualifier GO_term References
GO:0001948IEA-glycoprotein binding-
GO:0004559TAS-alpha-mannosidase activity-
GO:0004571IDANOTmannosyl-oligosaccharide 1,2-alpha-mannosidase activity12610306
GO:0004571IMP-mannosyl-oligosaccharide 1,2-alpha-mannosidase activity25092655
GO:0005509IEA-calcium ion binding-
GO:0005515IPI-protein binding16449189
GO:0051787IDA-misfolded protein binding19524542
GO ID Evidence Qualifier GO_term References
GO:0006491IBA-N-glycan processing-
GO:0030433ISS-ubiquitin-dependent ERAD pathway-
GO:0036498TAS-IRE1-mediated unfolded protein response-
GO:0036510IEA-trimming of terminal mannose on C branch-
GO:0097466IMP-ubiquitin-dependent glycoprotein ERAD pathway21062743
GO:1904154IGI-positive regulation of retrograde protein transport, ER to cytosol24200403
GO:1904154IMP-positive regulation of retrograde protein transport, ER to cytosol24200403
GO:1904382IMP-mannose trimming involved in glycoprotein ERAD pathway25092655
GO:1904382TAS-mannose trimming involved in glycoprotein ERAD pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
EDEM1CANX11504712610305 Affinity Capture-Western
EDEM1CANX10727112610305 Affinity Capture-Western
EDEM1BZW111504717353931 Affinity Capture-MS
EDEM1BZW111504217353931 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
EDEM1rs2305395, rs460362 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:2180139
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-808'