AutismKB 2.0

Annotation Details for CD74


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Basic Information Top
Gene Symbol:CD74 ( DHLAG,HLADG,II,Ia-GAMMA )
Gene Full Name: CD74 molecule, major histocompatibility complex, class II invariant chain
Band: 5q33.1
Quick LinksEntrez ID:972; OMIM: 142790; Uniprot ID:HG2A_HUMAN; ENSEMBL ID: ENSG00000019582; HGNC ID: 1697
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139TAS-Golgi membrane-
GO:0005622TAS-intracellular12782713
GO:0005765TAS-lysosomal membrane-
GO:0005771IEA-multivesicular body-
GO:0005773IDA-vacuole19849849
GO:0005886TAS-plasma membrane-
GO:0009897IEA-external side of plasma membrane-
GO:0009986IDA-cell surface17045821
GO:0012507TAS-ER to Golgi transport vesicle membrane-
GO:0016020IDA-membrane19946888
GO:0016021IDA-integral component of membrane12782713
GO:0030658TAS-transport vesicle membrane-
GO:0030666TAS-endocytic vesicle membrane-
GO:0030669TAS-clathrin-coated endocytic vesicle membrane-
GO:0032588TAS-trans-Golgi network membrane-
GO:0035692IDA-macrophage migration inhibitory factor receptor complex17045821
GO:0035693IEA-NOS2-CD74 complex-
GO:0042613ISScolocalizes_withMHC class II protein complex-
GO:0043202TAS-lysosomal lumen-
GO:0070062IDA-extracellular exosome20458337
GO:0071556TAS-integral component of lumenal side of endoplasmic reticulum membrane-
GO ID Evidence Qualifier GO_term References
GO:0001540IPI-amyloid-beta binding19849849
GO:0004896IDA-cytokine receptor activity17045821
GO:0005515IPI-protein binding19665027
GO:0019955IPI-cytokine binding12782713
GO:0023026IDA-MHC class II protein complex binding1448172
GO:0035718IPI-macrophage migration inhibitory factor binding17045821
GO:0042289ISS-MHC class II protein binding-
GO:0042289NAS-MHC class II protein binding10981873
GO:0042609IPI-CD4 receptor binding24942581
GO:0042658IDA-MHC class II protein binding, via antigen binding groove7477400
GO:0042802TAS-identical protein binding12782713
GO:0044183IDA-protein binding involved in protein folding7477400
GO:0050998IEA-nitric-oxide synthase binding-
GO ID Evidence Qualifier GO_term References
GO:0000187IEA-activation of MAPK activity-
GO:0001516IDA-prostaglandin biosynthetic process12782713
GO:0001934IDA-positive regulation of protein phosphorylation24942581
GO:0001961IMP-positive regulation of cytokine-mediated signaling pathway12782713
GO:0002606IEA-positive regulation of dendritic cell antigen processing and presentation-
GO:0002792IDA-negative regulation of peptide secretion19849849
GO:0002830IEA-positive regulation of type 2 immune response-
GO:0002906IEA-negative regulation of mature B cell apoptotic process-
GO:0006461ISS-protein complex assembly-
GO:0006886ISS-intracellular protein transport-
GO:0006952IEA-defense response-
GO:0007165IDA-signal transduction12782713
GO:0008283IDA-cell proliferation12782713
GO:0016064ISS-immunoglobulin mediated immune response-
GO:0019883NAS-antigen processing and presentation of endogenous antigen10981873
GO:0019886TAS-antigen processing and presentation of exogenous peptide antigen via MHC class II-
GO:0030890IMP-positive regulation of B cell proliferation12782713
GO:0033674IDA-positive regulation of kinase activity24942581
GO:0035691IEA-macrophage migration inhibitory factor signaling pathway-
GO:0043030NAS-regulation of macrophage activation12782713
GO:0043066IDA-negative regulation of apoptotic process12782713
GO:0043123IDA-positive regulation of I-kappaB kinase/NF-kappaB signaling24942581
GO:0043410IDA-positive regulation of MAPK cascade24942581
GO:0043518IDA-negative regulation of DNA damage response, signal transduction by p53 class mediator17045821
GO:0045058NAS-T cell selection10981873
GO:0045059IEA-positive thymic T cell selection-
GO:0045060IEA-negative thymic T cell selection-
GO:0045581IEA-negative regulation of T cell differentiation-
GO:0045582IEA-positive regulation of T cell differentiation-
GO:0045657IDA-positive regulation of monocyte differentiation24942581
GO:0045893IDA-positive regulation of transcription, DNA-templated24942581
GO:0046598IDA-positive regulation of viral entry into host cell24942581
GO:0048146IMP-positive regulation of fibroblast proliferation12782713
GO:0050731IDA-positive regulation of peptidyl-tyrosine phosphorylation17045821
GO:0050900TAS-leukocyte migration-
GO:0051085IEA-chaperone mediated protein folding requiring cofactor-
GO:0051290IDA-protein heterotetramerization24942581
GO:0060907ISS-positive regulation of macrophage cytokine production-
GO:0070374IDA-positive regulation of ERK1 and ERK2 cascade17045821
GO:0070374IMP-positive regulation of ERK1 and ERK2 cascade12782713
GO:0090023ISS-positive regulation of neutrophil chemotaxis-
GO:1902166IMP-negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator17045821
GO:2000343ISS-positive regulation of chemokine (C-X-C motif) ligand 2 production-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CD74CD741074102391366 Co-purification
MIFCD7411042812782713 Affinity Capture-Western; Reconstituted Complex
MIFCD7410741012782713 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96534
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-000901-1'